Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.0025 | 0.0045 |
Onchocerca volvulus | Alhambra homolog | 0.0035 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | alpha 16 mannosyl glycoprotein | 0.3087 | 0.5619 | 1 |
Giardia lamblia | PHD finger protein 15 | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0043 | 0.0014 | 0.0024 |
Treponema pallidum | licC protein (licC) | 0.1002 | 0.1781 | 0.5 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0115 | 0.0147 | 0.0263 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.0025 | 0.0045 |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.1002 | 0.1781 | 1 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.5466 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0046 | 0.0082 |
Plasmodium falciparum | phd finger protein, putative | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.5466 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.5466 | 1 | 0.5 |
Echinococcus multilocularis | alpha 1,6 mannosyl glycoprotein | 0.3087 | 0.5619 | 1 |
Brugia malayi | UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II | 0.3087 | 0.5619 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0059 | 0.0044 | 0.0078 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0059 | 0.0044 | 0.0078 |
Schistosoma mansoni | jumonji domain containing protein | 0.0092 | 0.0104 | 0.0185 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0043 | 0.0014 | 0.0024 |
Brugia malayi | jmjC domain containing protein | 0.0043 | 0.0014 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.3087 | 0.5619 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0115 | 0.0147 | 0.0263 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0043 | 0.0014 | 0.0024 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0014 | 0.0024 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0014 | 0.0024 |
Schistosoma mansoni | beta-12-n-acetylglucosaminyltransferase II | 0.3087 | 0.5619 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0115 | 0.0147 | 0.0263 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.0069 | 0.0123 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 3 % | Displacement of [3H]NECA from human Adenosine A3 receptor expressed in HeLa cells at 1 uM after 30 mins | ChEMBL. | 26824742 |
Activity (binding) | = 25 % | Displacement of [3H]DPCPX from human Adenosine A1 receptor expressed in CHO cells at 1 uM after 60 mins | ChEMBL. | 26824742 |
Activity (binding) | = 26 % | Displacement of [3H]ZM241385 from human Adenosine A2A receptor expressed in HeLa cells at 1 uM after 30 mins | ChEMBL. | 26824742 |
Inhibition (binding) | = 3 % | Displacement of [3H]NECA from adenosine A3 receptor in human HeLa cells at 10 uM after 180 mins | ChEMBL. | 24900602 |
Inhibition (binding) | = 25 % | Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells at 10 uM after 60 mins | ChEMBL. | 24900602 |
Inhibition (binding) | = 26 % | Displacement of [3H]ZM241385 from adenosine A2A receptor in human HeLa cells at 10 uM after 30 mins | ChEMBL. | 24900602 |
Ki (binding) | = 1486 nM | Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis | ChEMBL. | 24900602 |
Ki (binding) | = 1486 nM | Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins | ChEMBL. | 26824742 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.