Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Endothelin receptor ET-A | Starlite/ChEMBL | References |
Sus scrofa | Endothelin receptor ET-B | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | Endothelin receptor ET-A | 426 aa | 412 aa | 21.1 % |
Onchocerca volvulus | Endothelin receptor ET-B | 443 aa | 371 aa | 20.5 % | |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | Endothelin receptor ET-A | 426 aa | 412 aa | 20.1 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Endothelin receptor ET-B | 443 aa | 392 aa | 23.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1204 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0491 | 0.3709 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.045 | 0.3344 | 0.3236 |
Toxoplasma gondii | hypothetical protein | 0.1204 | 1 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.013 | 0.0524 | 0.1414 |
Loa Loa (eye worm) | hypothetical protein | 0.039 | 0.282 | 0.2704 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.045 | 0.3344 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.045 | 0.3344 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.013 | 0.0524 | 0.1145 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.0524 | 0.0371 |
Schistosoma mansoni | voltage-gated potassium channel | 0.013 | 0.0524 | 0.1414 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0089 | 0.016 | 0.043 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.045 | 0.3344 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.013 | 0.0524 | 0.1145 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0491 | 0.3709 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.013 | 0.0524 | 0.1145 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.013 | 0.0524 | 0.1145 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.042 | 0.3083 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0089 | 0.016 | 0.043 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0089 | 0.016 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.1204 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.042 | 0.3083 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0089 | 0.016 | 0.043 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0089 | 0.016 | 0.043 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.013 | 0.0524 | 0.1145 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.1204 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0089 | 0.016 | 0.043 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 18 nM | Ability to displace endothelin ([125I]-ET-1) from endothelin A receptor derived from MMQ cells of rodent. | ChEMBL. | 9379441 |
IC50 (binding) | = 18 nM | Ability to displace endothelin ([125I]-ET-1) from endothelin A receptor derived from MMQ cells of rodent. | ChEMBL. | 9379441 |
IC50 (binding) | = 68 nM | Ability to displace endothelin ([125I]-ET-3) from endothelin B receptor derived from cerebellar tissue of porcine. | ChEMBL. | 9379441 |
IC50 (binding) | = 68 nM | Ability to displace endothelin ([125I]-ET-3) from endothelin B receptor derived from cerebellar tissue of porcine. | ChEMBL. | 9379441 |
Ratio (binding) | = 3.8 | Ratio of endothelin A receptor and endothelin B receptor. | ChEMBL. | 9379441 |
Ratio (binding) | = 3.8 | Ratio of endothelin A receptor and endothelin B receptor. | ChEMBL. | 9379441 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.