Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 3.1724 | 0.936 | 0.936 |
Loa Loa (eye worm) | hypothetical protein | 3.3755 | 1 | 1 |
Mycobacterium ulcerans | transmembrane cation transporter | 0.2032 | 0 | 0.5 |
Leishmania major | ion transport protein-like protein | 0.2032 | 0 | 0.5 |
Plasmodium vivax | potassium channel, putative | 0.2032 | 0 | 0.5 |
Onchocerca volvulus | 0.2032 | 0 | 0.5 | |
Onchocerca volvulus | 0.2032 | 0 | 0.5 | |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.2032 | 0 | 0.5 |
Trypanosoma brucei | calcium/potassium channel (CAKC), putative | 0.2032 | 0 | 0.5 |
Trypanosoma cruzi | calcium-activated potassium channel, putative | 0.2032 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.2032 | 0 | 0.5 |
Mycobacterium ulcerans | ion transport protein | 0.2032 | 0 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.2032 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.2032 | 0 | 0.5 |
Trypanosoma cruzi | ion transport protein, putative | 0.2032 | 0 | 0.5 |
Trypanosoma cruzi | calcium/potassium channel (CAKC), putative | 0.2032 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.2032 | 0 | 0.5 |
Onchocerca volvulus | 0.2032 | 0 | 0.5 | |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.2032 | 0 | 0.5 |
Schistosoma mansoni | twik family of potassium channels-related | 3.3755 | 1 | 1 |
Onchocerca volvulus | 0.2032 | 0 | 0.5 | |
Echinococcus multilocularis | Two pore potassium channel protein sup 9 | 3.3755 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.2032 | 0 | 0.5 |
Leishmania major | calcium/potassium channel (CAKC), putative | 0.2032 | 0 | 0.5 |
Toxoplasma gondii | ion channel protein | 0.2032 | 0 | 0.5 |
Trypanosoma brucei | calcium-activated potassium channel, putative | 0.2032 | 0 | 0.5 |
Echinococcus granulosus | Two pore potassium channel protein sup 9 | 3.3755 | 1 | 1 |
Toxoplasma gondii | ion channel protein | 0.2032 | 0 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.2032 | 0 | 0.5 |
Trypanosoma cruzi | calcium-activated potassium channel, putative | 0.2032 | 0 | 0.5 |
Onchocerca volvulus | 0.2032 | 0 | 0.5 | |
Trypanosoma cruzi | calcium/potassium channel (CAKC), putative | 0.2032 | 0 | 0.5 |
Plasmodium falciparum | potassium channel | 0.2032 | 0 | 0.5 |
Onchocerca volvulus | 0.2032 | 0 | 0.5 | |
Entamoeba histolytica | calcium-gated potassium channel protein, putative | 0.2032 | 0 | 0.5 |
Onchocerca volvulus | 0.2032 | 0 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.2032 | 0 | 0.5 |
Plasmodium falciparum | potassium channel | 0.2032 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible transmembrane cation transporter | 0.2032 | 0 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.2032 | 0 | 0.5 |
Leishmania major | potassium channel subunit-like protein | 0.2032 | 0 | 0.5 |
Trypanosoma cruzi | ion transport protein, putative | 0.2032 | 0 | 0.5 |
Plasmodium vivax | potassium channel, putative | 0.2032 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 3.3755 | 1 | 1 |
Onchocerca volvulus | 0.2032 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 50 % | Inhibition of human COX2 using arachidonic acid as substrate assessed as formation of TMPD at 50 uM incubated for 5 mins prior to substrate addition measured after 5 mins by spectrophotometry | ChEMBL. | 24231650 |
Ka (binding) | = 390 nM | Binding affinity to human 5-LOX-linoleic acid complex by Lineweaver-Burk plot analysis | ChEMBL. | 24231650 |
Ka (binding) | = 8.65 uM | Binding affinity to human 5-LOX using linoleic acid as substrate by Lineweaver-Burk plot analysis | ChEMBL. | 24231650 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.