Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1589 | 0.1589 |
Brugia malayi | Protein kinase domain containing protein | 0.0048 | 0.0814 | 0.0692 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0056 | 0.1589 | 0.1478 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0048 | 0.0814 | 0.0814 |
Onchocerca volvulus | Matrilysin homolog | 0.0039 | 0 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.015 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.015 | 1 | 1 |
Echinococcus multilocularis | 0.0046 | 0.0678 | 0.0555 | |
Loa Loa (eye worm) | disintegrin family protein | 0.0062 | 0.2064 | 0.2064 |
Schistosoma mansoni | tyrosine kinase | 0.0048 | 0.0814 | 0.0692 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.008 | 0.3753 | 0.3671 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0039 | 0 | 0.5 |
Schistosoma mansoni | dihydroceramide desaturase | 0.0085 | 0.4146 | 0.4068 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0048 | 0.0814 | 0.0692 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.3753 | 0.3671 |
Echinococcus granulosus | epidermal growth factor receptor | 0.008 | 0.3753 | 0.3671 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.3677 | 0.3593 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.3753 | 0.3671 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.015 | 1 | 1 |
Echinococcus granulosus | disintegrin and metalloproteinase | 0.0085 | 0.4146 | 0.4068 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.015 | 1 | 1 |
Echinococcus multilocularis | disintegrin and metalloproteinase | 0.0085 | 0.4146 | 0.4068 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0042 | 0.0248 | 0.0119 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.3677 | 0.3593 |
Brugia malayi | Matrixin family protein | 0.0042 | 0.0316 | 0.0187 |
Echinococcus granulosus | insulin receptor | 0.0048 | 0.0814 | 0.0692 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.3677 | 0.3593 |
Brugia malayi | Disintegrin family protein | 0.0085 | 0.4146 | 0.4068 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0048 | 0.0814 | 0.0692 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0064 | 0.2238 | 0.2135 |
Loa Loa (eye worm) | matrixin family protein | 0.0042 | 0.0316 | 0.0316 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0064 | 0.2238 | 0.2135 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.008 | 0.3753 | 0.3671 |
Echinococcus multilocularis | insulin receptor | 0.0048 | 0.0814 | 0.0692 |
Schistosoma mansoni | tyrosine kinase | 0.0048 | 0.0814 | 0.0692 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0056 | 0.1589 | 0.1478 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.5 uM | In vitro inhibitory concentration of compound against human thrombin | ChEMBL. | 12646027 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.