Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | MDM2 proto-oncogene, E3 ubiquitin protein ligase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.0158 | 0.3647 | 0.8032 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1141 | 0.2513 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0091 | 0.1933 | 0.4256 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0193 | 0.4541 | 0.3233 |
Echinococcus granulosus | carbonic anhydrase II | 0.0193 | 0.4541 | 0.3233 |
Plasmodium falciparum | carbonic anhydrase | 0.0091 | 0.1933 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.1933 | 0.4256 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.1933 | 0.4256 |
Trypanosoma brucei | Prostaglandin E synthase | 0.0158 | 0.3647 | 0.8032 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0193 | 0.4541 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0091 | 0.1933 | 0.2328 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.1933 | 0.4256 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0091 | 0.1933 | 0.4256 |
Echinococcus multilocularis | tumor protein p63 | 0.0408 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0193 | 0.4541 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0193 | 0.4541 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0193 | 0.4541 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0193 | 0.4541 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0091 | 0.1933 | 0.4256 |
Toxoplasma gondii | prostaglandin-E synthase | 0.0158 | 0.3647 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0193 | 0.4541 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0193 | 0.4541 | 1 |
Onchocerca volvulus | 0.0158 | 0.3647 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.3647 | 0.8032 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0091 | 0.1933 | 0.4256 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0091 | 0.1933 | 0.4256 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0193 | 0.4541 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0091 | 0.1933 | 0.2328 |
Brugia malayi | hypothetical protein | 0.0158 | 0.3647 | 0.8032 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0091 | 0.1933 | 0.4256 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0193 | 0.4541 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0091 | 0.1933 | 0.2328 |
Schistosoma mansoni | hypothetical protein | 0.0091 | 0.1933 | 0.2328 |
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.0158 | 0.3647 | 0.8032 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.0158 | 0.3647 | 0.8032 |
Schistosoma mansoni | carbonic anhydrase | 0.0091 | 0.1933 | 0.2328 |
Leishmania major | carbonic anhydrase-like protein | 0.0193 | 0.4541 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CLH (ADMET) | = 20 uL/min | Intrinsic clearance in human hepatocytes measured per 10'6 cells | ChEMBL. | 24456472 |
IC50 (binding) | = 0.2 nM | Binding affinity to human GST-thrombin-tagged MDM2 assessed as inhibition of interaction with human p53 after 1 hr by HTRF assay | ChEMBL. | 24456472 |
IC50 (functional) | = 2.5 nM | Antiproliferative activity against human SJSA1 cells assessed as inhibition of EdU incorporation after 1 hr by Click-iT EdU HCS assay in presence of 10% human serum | ChEMBL. | 24456472 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 24456472 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.