Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | mitogen activated protein kinase | 0.026 | 0 | 0.5 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.1475 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.026 | 0 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.026 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1475 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.026 | 0 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.026 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.026 | 0 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.026 | 0 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.026 | 0 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.026 | 0 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.026 | 0 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.026 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.026 | 0 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.026 | 0 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.026 | 0 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.026 | 0 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.026 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.026 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.026 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1475 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.026 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 56.8 % | Antagonist activity at smoothened (unknown origin) expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Shh signaling at 2 uM by dual luciferase reporter gene assay | ChEMBL. | 24491459 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.