Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0179 | 0.2877 | 0.1668 |
Echinococcus granulosus | hexokinase type 2 | 0.0174 | 0.2742 | 0.1511 |
Echinococcus multilocularis | caspase 3 | 0.0302 | 0.6362 | 0.5745 |
Loa Loa (eye worm) | hexokinase | 0.0174 | 0.2742 | 0.9533 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0135 | 0.1628 | 0.566 |
Brugia malayi | Hexokinase family protein | 0.0109 | 0.0905 | 0.3147 |
Onchocerca volvulus | 0.0174 | 0.2742 | 1 | |
Echinococcus granulosus | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1175 | 0.4085 |
Leishmania major | hexokinase, putative | 0.0174 | 0.2742 | 0.9058 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.1628 | 0.566 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0179 | 0.2877 | 1 |
Trypanosoma brucei | hexokinase | 0.0174 | 0.2742 | 0.9058 |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Trypanosoma cruzi | hexokinase, putative | 0.0174 | 0.2742 | 0.9058 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0179 | 0.2877 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.2656 | 0.9232 |
Schistosoma mansoni | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Loa Loa (eye worm) | hexokinase type II | 0.0174 | 0.2742 | 0.9533 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0179 | 0.2877 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0174 | 0.2742 | 0.9058 |
Brugia malayi | Hexokinase family protein | 0.0174 | 0.2742 | 0.9533 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0179 | 0.2877 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0179 | 0.2877 | 1 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0431 | 1 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0179 | 0.2877 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0431 | 1 | 1 |
Echinococcus granulosus | caspase | 0.0431 | 1 | 1 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0171 | 0.2656 | 0.9684 |
Onchocerca volvulus | 0.0109 | 0.0905 | 0.3301 | |
Echinococcus multilocularis | caspase | 0.0431 | 1 | 1 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0135 | 0.1628 | 0.566 |
Echinococcus granulosus | caspase 3 | 0.0302 | 0.6362 | 0.5745 |
Trypanosoma brucei | protein kinase, putative | 0.0179 | 0.2877 | 1 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0431 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0179 | 0.2877 | 0.1668 |
Echinococcus granulosus | caspase 2 | 0.0171 | 0.2656 | 0.141 |
Onchocerca volvulus | 0.0174 | 0.2742 | 1 | |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0179 | 0.2877 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0109 | 0.0905 | 0.3147 |
Entamoeba histolytica | hexokinase 2 | 0.0174 | 0.2742 | 0.5 |
Echinococcus multilocularis | caspase 2 | 0.0171 | 0.2656 | 0.141 |
Leishmania major | hexokinase, putative | 0.0174 | 0.2742 | 0.9058 |
Echinococcus granulosus | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Echinococcus multilocularis | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Echinococcus granulosus | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0179 | 0.2877 | 1 |
Trypanosoma brucei | hexokinase, putative | 0.0174 | 0.2742 | 0.9058 |
Echinococcus multilocularis | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0179 | 0.2877 | 1 |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Echinococcus multilocularis | hexokinase | 0.0174 | 0.2742 | 0.1511 |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0179 | 0.2877 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0179 | 0.2877 | 0.1668 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0171 | 0.2656 | 0.141 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0179 | 0.2877 | 0.1668 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0179 | 0.2877 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0174 | 0.2742 | 0.5 |
Toxoplasma gondii | hexokinase | 0.0174 | 0.2742 | 0.9058 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0179 | 0.2877 | 0.5 |
Plasmodium vivax | hexokinase, putative | 0.0174 | 0.2742 | 1 |
Echinococcus multilocularis | hexokinase type 2 | 0.0174 | 0.2742 | 0.1511 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0179 | 0.2877 | 0.1668 |
Loa Loa (eye worm) | hexokinase | 0.0174 | 0.2742 | 0.9533 |
Plasmodium falciparum | hexokinase | 0.0174 | 0.2742 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.1451 | 0.5043 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0135 | 0.1628 | 0.566 |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Brugia malayi | Cell death protein 3 precursor | 0.0171 | 0.2656 | 0.9232 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0135 | 0.1628 | 0.566 |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 | |
Brugia malayi | hexokinase | 0.0174 | 0.2742 | 0.9533 |
Entamoeba histolytica | hexokinase 1 | 0.0174 | 0.2742 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0179 | 0.2877 | 1 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0129 | 0.1451 | 0.5043 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0179 | 0.2877 | 1 |
Onchocerca volvulus | Hexokinase homolog | 0.0109 | 0.0905 | 0.3301 |
Onchocerca volvulus | 0.0174 | 0.2742 | 1 | |
Trypanosoma brucei | hexokinase | 0.0174 | 0.2742 | 0.9058 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0179 | 0.2877 | 1 |
Onchocerca volvulus | 0.0135 | 0.1628 | 0.5937 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.