Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | p21 protein (Cdc42/Rac)-activated kinase 1 | Starlite/ChEMBL | References |
Homo sapiens | p21 protein (Cdc42/Rac)-activated kinase 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | cdc48-like protein, putative | 0.1026 | 0.9457 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.1082 | 1 | 1 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.1026 | 0.9457 | 1 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.1082 | 1 | 0.5 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0064 | 0.0085 | 0.0085 |
Trypanosoma brucei | Valosin-containing protein | 0.1026 | 0.9457 | 1 |
Mycobacterium ulcerans | ATPase | 0.0647 | 0.5767 | 0.5 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.1026 | 0.9457 | 1 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0647 | 0.5767 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0064 | 0.0085 | 0.0085 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.024 | 0.1795 | 0.3183 |
Giardia lamblia | Kinase, STE STE20 | 0.0064 | 0.0085 | 0.0148 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0064 | 0.0085 | 0.0085 |
Toxoplasma gondii | cell division protein CDC48CY | 0.1082 | 1 | 1 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.1026 | 0.9457 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0064 | 0.0085 | 0.0085 |
Loa Loa (eye worm) | VCP protein | 0.0447 | 0.3817 | 0.6768 |
Trichomonas vaginalis | STE family protein kinase | 0.0064 | 0.0085 | 0.0085 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0064 | 0.0085 | 0.0085 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0634 | 0.564 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.0202 | 0.1428 | 0.1428 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.1082 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0064 | 0.0085 | 0.0085 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0064 | 0.0078 | 0.0078 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.1082 | 1 | 1 |
Brugia malayi | transitional endoplasmic reticulum ATPase TER94, putative | 0.0447 | 0.3817 | 0.6768 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0064 | 0.0085 | 0.0085 |
Brugia malayi | Protein kinase domain | 0.0064 | 0.0085 | 0.0151 |
Brugia malayi | valosin containing protein | 0.0634 | 0.564 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0064 | 0.0085 | 0.0085 |
Trichomonas vaginalis | 26S protease regulatory subunit S10b, putative | 0.0256 | 0.195 | 0.195 |
Loa Loa (eye worm) | hypothetical protein | 0.0634 | 0.564 | 1 |
Brugia malayi | vesicle-fusing ATPase | 0.0634 | 0.564 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0078 | 0.0139 |
Brugia malayi | serine/threonine-protein kinase PAK 7 | 0.024 | 0.1795 | 0.3183 |
Entamoeba histolytica | protein kinase, putative | 0.0064 | 0.0085 | 0.009 |
Trichomonas vaginalis | proteasome-activating nucleotidase, putative | 0.0256 | 0.195 | 0.195 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.1026 | 0.9457 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0064 | 0.0085 | 0.0085 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0647 | 0.5767 | 0.5767 |
Toxoplasma gondii | transitional endoplasmic reticulum ATPase, putative | 0.0647 | 0.5767 | 0.5767 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.0202 | 0.1428 | 0.1428 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0447 | 0.3817 | 0.3817 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.1026 | 0.9457 | 0.9457 |
Giardia lamblia | AAA family ATPase | 0.0647 | 0.5767 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0447 | 0.3817 | 0.3817 |
Entamoeba histolytica | p21-activated kinase | 0.0064 | 0.0085 | 0.009 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.1026 | 0.9457 | 1 |
Schistosoma mansoni | protein kinase | 0.0064 | 0.0085 | 0.0085 |
Schistosoma mansoni | protein kinase | 0.0064 | 0.0085 | 0.0085 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.032 uM | Binding affinity to N-terminal GST-tagged recombinant human PAK4 kinase domain expressed in Escherichia coli using KKRNRRLSVA as substrate preincubated for 10 mins followed by ATP addition measured after 60 mins by FRET-based Z'Lyte assay | ChEMBL. | 24432870 |
Ki (binding) | > 4.5 uM | Binding affinity to N-terminal GST-His-tagged recombinant human PAK1 kinase domain expressed in Escherichia coli BL21 using KKRNRRLSVA as sustrate preincubated for 10 mins followed by ATP addition measured after 60 mins by FRET-based Z'Lyte assay | ChEMBL. | 24432870 |
Ratio Ki (binding) | = 15.6 | Potency index, ratio of P3758309 Ki to compound Ki for human PAK4 kinase domain | ChEMBL. | 24432870 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.