Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | p21 protein (Cdc42/Rac)-activated kinase 4 | Starlite/ChEMBL | References |
Homo sapiens | p21 protein (Cdc42/Rac)-activated kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | carbonic anhydrase-related | 0.036 | 0.5134 | 0.5134 |
Echinococcus granulosus | carbonic anhydrase | 0.036 | 0.5134 | 0.4923 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0665 | 1 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.036 | 0.5134 | 0.4923 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0665 | 1 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.036 | 0.5134 | 0.4923 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0665 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.036 | 0.5134 | 0.493 |
Schistosoma mansoni | hypothetical protein | 0.036 | 0.5134 | 0.5134 |
Giardia lamblia | Kinase, STE STE20 | 0.0064 | 0.0416 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.036 | 0.5134 | 0.5134 |
Brugia malayi | serine/threonine-protein kinase PAK 7 | 0.024 | 0.3214 | 0.292 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.036 | 0.5134 | 0.4923 |
Trichomonas vaginalis | STE family protein kinase | 0.0064 | 0.0416 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.036 | 0.5134 | 0.4923 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0064 | 0.0416 | 0.0416 |
Schistosoma mansoni | protein kinase | 0.0064 | 0.0416 | 0.0416 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0064 | 0.0416 | 0.0416 |
Echinococcus granulosus | carbonic anhydrase | 0.036 | 0.5134 | 0.4923 |
Echinococcus multilocularis | carbonic anhydrase | 0.036 | 0.5134 | 0.5134 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0665 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0665 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0665 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0665 | 1 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0064 | 0.0416 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0665 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.036 | 0.5134 | 0.5134 |
Loa Loa (eye worm) | hypothetical protein | 0.036 | 0.5134 | 0.493 |
Trichomonas vaginalis | STE family protein kinase | 0.0064 | 0.0416 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.036 | 0.5134 | 0.5134 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0064 | 0.0404 | 0.9715 |
Echinococcus granulosus | carbonic anhydrase II | 0.0665 | 1 | 1 |
Entamoeba histolytica | p21-activated kinase | 0.0064 | 0.0416 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.036 | 0.5134 | 0.4923 |
Schistosoma mansoni | protein kinase | 0.0064 | 0.0416 | 0.0416 |
Echinococcus multilocularis | carbonic anhydrase | 0.036 | 0.5134 | 0.5134 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0064 | 0.0416 | 0.0416 |
Loa Loa (eye worm) | hypothetical protein | 0.036 | 0.5134 | 0.493 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.036 | 0.5134 | 0.4923 |
Entamoeba histolytica | protein kinase, putative | 0.0064 | 0.0416 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0064 | 0.0416 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.0202 | 0.2613 | 0.2613 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0665 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.036 | 0.5134 | 0.5 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.024 | 0.3214 | 0.2929 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.0202 | 0.2613 | 0.2293 |
Schistosoma mansoni | carbonic anhydrase-related | 0.036 | 0.5134 | 0.5134 |
Loa Loa (eye worm) | hypothetical protein | 0.036 | 0.5134 | 0.493 |
Plasmodium falciparum | carbonic anhydrase | 0.036 | 0.5134 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.0665 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.6 uM | Binding affinity to N-terminal GST-tagged recombinant human PAK4 kinase domain expressed in Escherichia coli using KKRNRRLSVA as substrate preincubated for 10 mins followed by ATP addition measured after 60 mins by FRET-based Z'Lyte assay | ChEMBL. | 24432870 |
Ki (binding) | > 4.5 uM | Binding affinity to N-terminal GST-His-tagged recombinant human PAK1 kinase domain expressed in Escherichia coli BL21 using KKRNRRLSVA as sustrate preincubated for 10 mins followed by ATP addition measured after 60 mins by FRET-based Z'Lyte assay | ChEMBL. | 24432870 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.