Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog | 0.006 | 0.0057 | 0.0046 |
Brugia malayi | Protein kinase domain containing protein | 0.119 | 0.5284 | 0.5279 |
Echinococcus granulosus | carbonic anhydrase | 0.0994 | 0.4376 | 0.4376 |
Echinococcus granulosus | sodium channel protein | 0.0051 | 0.0013 | 0.0013 |
Loa Loa (eye worm) | TTK protein kinase | 0.119 | 0.5284 | 0.5279 |
Echinococcus granulosus | carbonic anhydrase | 0.0994 | 0.4376 | 0.4376 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0994 | 0.4376 | 0.4369 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0286 | 0.0275 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.119 | 0.5284 | 0.5284 |
Leishmania major | carbonic anhydrase-like protein | 0.2209 | 1 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.2209 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2209 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0107 | 0.0276 | 0.0265 |
Schistosoma mansoni | carbonic anhydrase | 0.0994 | 0.4376 | 0.4369 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0109 | 0.0286 | 0.0275 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0051 | 0.0013 | 0.0013 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.006 | 0.0057 | 0.0057 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0994 | 0.4376 | 0.4369 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.2209 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0306 | 0.0294 |
Loa Loa (eye worm) | hypothetical protein | 0.0994 | 0.4376 | 0.4369 |
Schistosoma mansoni | hypothetical protein | 0.0994 | 0.4376 | 0.4369 |
Echinococcus granulosus | carbonic anhydrase II | 0.2209 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0994 | 0.4376 | 0.4369 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2209 | 1 | 0.5 |
Echinococcus granulosus | shaker cognate | 0.006 | 0.0057 | 0.0057 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0994 | 0.4376 | 0.4369 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0994 | 0.4376 | 0.4369 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.119 | 0.5284 | 0.5279 |
Echinococcus multilocularis | shaker cognate | 0.006 | 0.0057 | 0.0057 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0107 | 0.0276 | 0.0276 |
Schistosoma mansoni | voltage-gated potassium channel | 0.006 | 0.0057 | 0.0046 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0096 | 0.0224 | 0.0213 |
Trichomonas vaginalis | CAMK family protein kinase | 0.119 | 0.5284 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0994 | 0.4376 | 0.4369 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0109 | 0.0286 | 0.0286 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0994 | 0.4376 | 0.4369 |
Echinococcus multilocularis | carbonic anhydrase | 0.0994 | 0.4376 | 0.4376 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.01 | 0.024 | 0.024 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0109 | 0.0286 | 0.0275 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0994 | 0.4376 | 0.4369 |
Echinococcus granulosus | carbonic anhydrase | 0.0994 | 0.4376 | 0.4376 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.119 | 0.5284 | 0.5284 |
Echinococcus multilocularis | sodium channel protein | 0.0051 | 0.0013 | 0.0013 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.2209 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.119 | 0.5284 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0109 | 0.0286 | 0.0275 |
Toxoplasma gondii | hypothetical protein | 0.0994 | 0.4376 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0994 | 0.4376 | 0.4369 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0994 | 0.4376 | 0.4369 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0994 | 0.4376 | 0.4369 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0107 | 0.0276 | 0.0276 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2209 | 1 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0994 | 0.4376 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog | 0.0096 | 0.0224 | 0.0213 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2209 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.2209 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0114 | 0.0306 | 0.0294 |
Echinococcus multilocularis | carbonic anhydrase II | 0.2209 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0109 | 0.0286 | 0.0286 |
Echinococcus multilocularis | carbonic anhydrase | 0.0994 | 0.4376 | 0.4376 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.119 | 0.5284 | 0.5 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.006 | 0.0057 | 0.0046 |
Giardia lamblia | Kinase, TTK | 0.119 | 0.5284 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0994 | 0.4376 | 0.4376 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0109 | 0.0286 | 0.0286 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.006 | 0.0057 | 0.0057 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antibacterial activity against Escherichia coli CCM 3954 after 24 hrs | ChEMBL. | 24397620 | |
Activity (functional) | Antifungal activity against Candida albicans after 48 hrs | ChEMBL. | 24397620 | |
Activity (functional) | Antibacterial activity against multi-resistant Escherichia coli C/16702 after 24 hrs | ChEMBL. | 24397620 | |
IC50 (functional) | = 1.32 uM | Antiproliferative activity against human HepG2 cells after 72 hrs by XTT assay | ChEMBL. | 24397620 |
IC50 (ADMET) | = 36.1 uM | Cytostatic activity against human MRC5 cells after 72 hrs by MTT assay | ChEMBL. | 24397620 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 24397620 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.