Detailed information for compound 182850

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 220.311 | Formula: C13H20N2O
  • H donors: 0 H acceptors: 0 LogP: 2.01 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC#CCCO/N=C/1\CC2CCC(C1)N2C
  • InChi: 1S/C13H20N2O/c1-3-4-5-8-16-14-11-9-12-6-7-13(10-11)15(12)2/h12-13H,5-10H2,1-2H3
  • InChiKey: YELNTEFGUNYOQG-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0983 0.1757 0.1757
Loa Loa (eye worm) hypothetical protein 0.147 0.4484 0.4484
Echinococcus multilocularis natriuretic peptide receptor 1 0.0983 0.1757 0.1757
Brugia malayi Protein kinase domain containing protein 0.0983 0.1757 0.1757
Schistosoma mansoni tyrosine kinase 0.2453 1 1
Echinococcus multilocularis tyrosine kinase 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Brugia malayi SH2 domain containing protein 0.2453 1 1
Brugia malayi SH2 domain containing protein 0.147 0.4484 0.4484
Echinococcus granulosus c src tyrosine kinase 0.2453 1 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0983 0.1757 0.1757
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0983 0.1757 0.1757
Echinococcus granulosus retinal guanylyl cyclase 2 0.0983 0.1757 0.1757
Plasmodium falciparum protein kinase, putative 0.0983 0.1757 0.5
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0983 0.1757 0.5
Loa Loa (eye worm) variant SH3 domain-containing protein 0.147 0.4484 0.4484
Echinococcus multilocularis protein KINase family member (kin 25) 0.0983 0.1757 0.1757
Echinococcus granulosus tyrosine protein kinase Fyn 0.2453 1 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.2453 1 1
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0983 0.1757 0.1757
Loa Loa (eye worm) RhoGAP domain-containing protein 0.147 0.4484 0.4484
Echinococcus multilocularis tyrosine protein kinase Src42A 0.2453 1 1
Brugia malayi ephrin receptor 1 precursor 0.0983 0.1757 0.1757
Loa Loa (eye worm) hypothetical protein 0.147 0.4484 0.4484
Brugia malayi amidase 0.1569 0.5042 0.5042
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Loa Loa (eye worm) hypothetical protein 0.0983 0.1757 0.1757
Brugia malayi SH2 domain containing protein 0.147 0.4484 0.4484
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0983 0.1757 0.1757
Schistosoma mansoni adapter molecule crk 0.147 0.4484 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Brugia malayi Protein kinase domain containing protein 0.2453 1 1
Trypanosoma brucei Pseudokinase, putative 0.0983 0.1757 1
Trypanosoma brucei protein kinase, putative 0.0983 0.1757 1
Echinococcus multilocularis kinase suppressor of Ras 1 0.0983 0.1757 0.1757
Echinococcus multilocularis insulin receptor 0.0983 0.1757 0.1757
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0983 0.1757 0.1757
Echinococcus granulosus tyrosine protein kinase HCK 0.0983 0.1757 0.1757
Schistosoma mansoni hypothetical protein 0.147 0.4484 0.3309
Brugia malayi Variant SH3 domain containing protein 0.147 0.4484 0.4484
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Giardia lamblia Protein 21.1 0.0983 0.1757 0.5
Loa Loa (eye worm) hypothetical protein 0.147 0.4484 0.4484
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0983 0.1757 1
Loa Loa (eye worm) hypothetical protein 0.0983 0.1757 0.1757
Echinococcus granulosus kinase suppressor of Ras 1 0.0983 0.1757 0.1757
Plasmodium falciparum tyrosine kinase-like protein 0.0983 0.1757 0.5
Brugia malayi integrin-linked kinase 0.0983 0.1757 0.1757
Trichomonas vaginalis conserved hypothetical protein 0.0983 0.1757 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Trichomonas vaginalis conserved hypothetical protein 0.0983 0.1757 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.2453 1 1
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0983 0.1757 0.1757
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.147 0.4484 0.4484
Echinococcus granulosus protein tyrosine kinase 0.0983 0.1757 0.1757
Brugia malayi C-terminal src kinase protein 1 0.0983 0.1757 0.1757
Brugia malayi bone morphogenetic protein type 1 receptor 0.0983 0.1757 0.1757
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0983 0.1757 0.1757
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.147 0.4484 0.3309
Schistosoma mansoni tensin 0.147 0.4484 0.3309
Echinococcus granulosus activated cdc42 kinase 1 0.0983 0.1757 0.1757
Loa Loa (eye worm) hypothetical protein 0.147 0.4484 0.4484
Loa Loa (eye worm) hypothetical protein 0.0983 0.1757 0.1757
Brugia malayi Variant SH3 domain containing protein 0.147 0.4484 0.4484
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0983 0.1757 0.1757
Echinococcus multilocularis tyrosine protein kinase Src64B 0.2453 1 1
Brugia malayi Protein kinase domain containing protein 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.147 0.4484 0.4484
Onchocerca volvulus 0.2453 1 1
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Loa Loa (eye worm) TK protein kinase 0.0983 0.1757 0.1757
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.147 0.4484 0.3309
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0983 0.1757 0.1757
Loa Loa (eye worm) hypothetical protein 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Schistosoma mansoni vav2 0.147 0.4484 0.3309
Schistosoma mansoni GTPase activating protein 0.147 0.4484 0.3309
Brugia malayi Protein kinase domain containing protein 0.0983 0.1757 0.1757
Onchocerca volvulus 0.147 0.4484 0.4484
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Echinococcus granulosus raf serine:threonine protein kinase 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.2453 1 1
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0983 0.1757 0.1757
Echinococcus multilocularis tyrosine protein kinase Blk 0.2453 1 1
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Onchocerca volvulus 0.147 0.4484 0.4484
Echinococcus granulosus tyrosine protein kinase Fps85D 0.2453 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.2453 1 1
Loa Loa (eye worm) hypothetical protein 0.147 0.4484 0.4484
Brugia malayi RhoGAP domain containing protein 0.147 0.4484 0.4484
Brugia malayi cytokine inducible SH2-containing protein 5 0.147 0.4484 0.4484
Leishmania major hypothetical protein, conserved 0.0983 0.1757 1
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Echinococcus granulosus NCK adaptor protein 0.147 0.4484 0.4484
Loa Loa (eye worm) TK protein kinase 0.0983 0.1757 0.1757
Brugia malayi Protein kinase domain containing protein 0.0983 0.1757 0.1757
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0983 0.1757 0.1757
Echinococcus multilocularis signal transduction protein lnk realted 0.147 0.4484 0.4484
Brugia malayi Variant SH3 domain containing protein 0.147 0.4484 0.4484
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0983 0.1757 0.1757
Echinococcus granulosus tyrosine protein kinase csk 0.0983 0.1757 0.1757
Loa Loa (eye worm) TK protein kinase 0.0983 0.1757 0.1757
Brugia malayi Protein kinase domain containing protein 0.0983 0.1757 0.1757
Loa Loa (eye worm) hypothetical protein 0.147 0.4484 0.4484
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0983 0.1757 1
Trichomonas vaginalis CAMK family protein kinase 0.0983 0.1757 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.2453 1 1
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0983 0.1757 0.5
Schistosoma mansoni tyrosine kinase 0.2453 1 1
Schistosoma mansoni fatty-acid amide hydrolase 0.1569 0.5042 0.3985
Loa Loa (eye worm) TK protein kinase 0.0983 0.1757 0.1757
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2453 1 1
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Loa Loa (eye worm) TK protein kinase 0.0983 0.1757 0.1757
Plasmodium falciparum protein kinase, putative 0.0983 0.1757 0.5
Echinococcus granulosus protein kinase 0.0983 0.1757 0.1757
Toxoplasma gondii protein kinase 0.0983 0.1757 0.5
Schistosoma mansoni tyrosine kinase 0.2453 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2453 1 1
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0983 0.1757 0.1757
Brugia malayi Protein kinase domain containing protein 0.0983 0.1757 0.1757
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0983 0.1757 0.1757
Brugia malayi STAT protein, DNA binding domain containing protein 0.147 0.4484 0.4484
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0983 0.1757 0.1757
Brugia malayi Raf kinase 0.0983 0.1757 0.1757
Echinococcus granulosus activin receptor type 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0983 0.1757 0.1757
Brugia malayi Protein kinase domain containing protein 0.0983 0.1757 0.1757
Schistosoma mansoni growth factor receptor-bound protein 0.147 0.4484 0.3309
Echinococcus granulosus retinal guanylyl cyclase 2 0.0983 0.1757 0.1757
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.147 0.4484 0.3309
Onchocerca volvulus 0.2453 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0983 0.1757 0.1757
Onchocerca volvulus 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Echinococcus multilocularis tyrosine protein kinase shark 0.2453 1 1
Trichomonas vaginalis STE family protein kinase 0.0983 0.1757 1
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Echinococcus multilocularis heat shock protein 70 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0983 0.1757 0.1757
Echinococcus granulosus SH2 motif 0.147 0.4484 0.4484
Echinococcus multilocularis tensin 0.147 0.4484 0.4484
Brugia malayi Guanylyl cyclase protein 23 0.0983 0.1757 0.1757
Trichomonas vaginalis TK family protein kinase 0.0983 0.1757 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.0983 0.1757 0.1757
Brugia malayi protein-tyrosine kinase 0.2453 1 1
Echinococcus granulosus suppressor of cytokine signaling 7 0.147 0.4484 0.4484
Onchocerca volvulus 0.2453 1 1
Onchocerca volvulus 0.2453 1 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0983 0.1757 0.1757
Echinococcus multilocularis tyrosine protein kinase 0.0983 0.1757 0.1757
Loa Loa (eye worm) hypothetical protein 0.0983 0.1757 0.1757
Loa Loa (eye worm) hypothetical protein 0.2453 1 1
Schistosoma mansoni tensin-related 0.147 0.4484 0.3309
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.2453 1 1
Echinococcus granulosus tyrosine kinase 0.2453 1 1
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Brugia malayi Protein kinase domain containing protein 0.0983 0.1757 0.1757
Loa Loa (eye worm) hypothetical protein 0.1569 0.5042 0.5042
Echinococcus multilocularis ephrin type A receptor 4 A 0.0983 0.1757 0.1757
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0983 0.1757 0.1757
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Giardia lamblia Kinase, NEK 0.0983 0.1757 0.5
Plasmodium falciparum tyrosine kinase-like protein 0.0983 0.1757 0.5
Brugia malayi SRC-1 0.2453 1 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.147 0.4484 0.4484
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.2453 1 1
Echinococcus multilocularis N chimaerin 0.147 0.4484 0.4484
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Schistosoma mansoni tensin 0.147 0.4484 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Onchocerca volvulus 0.0983 0.1757 0.1757
Echinococcus multilocularis tyrosine protein kinase csk 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Brugia malayi tRNA modification GTPase TrmE family protein 0.147 0.4484 0.4484
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Loa Loa (eye worm) protein kinase domain-containing protein 0.0983 0.1757 0.1757
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0983 0.1757 1
Brugia malayi Protein kinase domain containing protein 0.0983 0.1757 0.1757
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Onchocerca volvulus 0.147 0.4484 0.4484
Onchocerca volvulus 0.2453 1 1
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Loa Loa (eye worm) hypothetical protein 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1569 0.5042 0.5042
Echinococcus granulosus tyrosine protein kinase Src42A 0.2453 1 1
Onchocerca volvulus 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Plasmodium falciparum protein kinase, putative 0.0983 0.1757 0.5
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Trichomonas vaginalis conserved hypothetical protein 0.0983 0.1757 1
Schistosoma mansoni suppressor of cytokine signaling 0.147 0.4484 0.3309
Echinococcus multilocularis tensin 0.147 0.4484 0.4484
Schistosoma mansoni growth factor receptor-bound protein 0.147 0.4484 0.3309
Trichomonas vaginalis protein kinase atn1, putative 0.0983 0.1757 1
Loa Loa (eye worm) hypothetical protein 0.147 0.4484 0.4484
Echinococcus granulosus tyrosine protein kinase Btk29A 0.2453 1 1
Schistosoma mansoni suppressor of cytokine signaling 0.147 0.4484 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0983 0.1757 0.1757
Loa Loa (eye worm) TK/FER protein kinase 0.2453 1 1
Brugia malayi Tensin 0.147 0.4484 0.4484
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Trichomonas vaginalis conserved hypothetical protein 0.0983 0.1757 1
Loa Loa (eye worm) TK protein kinase 0.0983 0.1757 0.1757
Echinococcus multilocularis raf serine:threonine protein kinase 0.0983 0.1757 0.1757
Echinococcus multilocularis tyrosine protein kinase pr2 0.0983 0.1757 0.1757
Echinococcus granulosus epidermal growth factor receptor 0.0983 0.1757 0.1757
Echinococcus multilocularis epidermal growth factor receptor 0.0983 0.1757 0.1757
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.147 0.4484 0.3309
Echinococcus granulosus insulin receptor 0.0983 0.1757 0.1757
Loa Loa (eye worm) TK/ROR protein kinase 0.0983 0.1757 0.1757
Echinococcus granulosus tensin 0.147 0.4484 0.4484
Loa Loa (eye worm) TK protein kinase 0.0983 0.1757 0.1757
Loa Loa (eye worm) hypothetical protein 0.0983 0.1757 0.1757
Echinococcus multilocularis 0.147 0.4484 0.4484
Onchocerca volvulus 0.0983 0.1757 0.1757
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0983 0.1757 1
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0983 0.1757 0.1757
Loa Loa (eye worm) sex muscle abnormal protein 5 0.147 0.4484 0.4484
Loa Loa (eye worm) hypothetical protein 0.0983 0.1757 0.1757
Loa Loa (eye worm) TK/FER protein kinase 0.2453 1 1
Brugia malayi Protein kinase domain containing protein 0.2453 1 1
Brugia malayi SH2 domain containing protein 0.147 0.4484 0.4484
Loa Loa (eye worm) hypothetical protein 0.147 0.4484 0.4484
Echinococcus granulosus SH2 domain containing protein 7 0.147 0.4484 0.4484
Loa Loa (eye worm) hypothetical protein 0.147 0.4484 0.4484
Leishmania major protein kinase, putative 0.0983 0.1757 1
Brugia malayi Protein kinase domain containing protein 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Loa Loa (eye worm) SH2 domain-containing protein 0.147 0.4484 0.4484
Brugia malayi Protein-tyrosine phosphatase containing protein 0.147 0.4484 0.4484
Brugia malayi hypothetical protein 0.147 0.4484 0.4484
Brugia malayi Protein kinase domain containing protein 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Schistosoma mansoni tyrosine kinase 0.2453 1 1
Brugia malayi Protein kinase domain containing protein 0.0983 0.1757 0.1757
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0983 0.1757 0.1757
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.147 0.4484 0.4484
Echinococcus granulosus expressed conserved protein 0.147 0.4484 0.4484
Echinococcus granulosus tyrosine protein kinase csk 0.0983 0.1757 0.1757
Loa Loa (eye worm) TK/FER protein kinase 0.0983 0.1757 0.1757
Echinococcus granulosus tyrosine protein kinase shark 0.2453 1 1
Brugia malayi Protein kinase domain containing protein 0.0983 0.1757 0.1757
Brugia malayi Protein kinase domain containing protein 0.2453 1 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Echinococcus granulosus growth factor receptor bound protein 2 0.147 0.4484 0.4484
Brugia malayi Protein kinase domain containing protein 0.0983 0.1757 0.1757
Loa Loa (eye worm) TK/CSK protein kinase 0.0983 0.1757 0.1757
Loa Loa (eye worm) TK/ALK protein kinase 0.0983 0.1757 0.1757
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.147 0.4484 0.4484
Loa Loa (eye worm) hypothetical protein 0.0983 0.1757 0.1757
Echinococcus multilocularis tyrosine protein kinase Srms 0.2453 1 1
Schistosoma mansoni SH2A 0.147 0.4484 0.3309
Entamoeba histolytica SH2-protein kinase domain containing protein 0.147 0.4484 0.3309
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0983 0.1757 0.1757
Loa Loa (eye worm) TK/RYK protein kinase 0.0983 0.1757 0.1757
Echinococcus multilocularis transfer RNA-Thr 0.0983 0.1757 0.1757
Onchocerca volvulus 0.147 0.4484 0.4484
Echinococcus multilocularis suppressor of cytokine signaling 7 0.147 0.4484 0.4484
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.147 0.4484 0.4484
Schistosoma mansoni tyrosine kinase 0.2453 1 1
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Loa Loa (eye worm) TK/FER protein kinase 0.2453 1 1
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Loa Loa (eye worm) TK/FER protein kinase 0.0983 0.1757 0.1757
Loa Loa (eye worm) TK/FER protein kinase 0.2453 1 1
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Brugia malayi Protein kinase domain containing protein 0.0983 0.1757 0.1757
Brugia malayi Variant SH3 domain containing protein 0.147 0.4484 0.4484
Entamoeba histolytica SH2 domain containing protein 0.147 0.4484 0.3309
Mycobacterium ulcerans carboxylesterase, LipT 0.0974 0.1706 0.5
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0983 0.1757 0.1757
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0983 0.1757 0.1757
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0983 0.1757 0.1757
Loa Loa (eye worm) protein-tyrosine phosphatase 0.147 0.4484 0.4484
Echinococcus granulosus tyrosine protein kinase Blk 0.2453 1 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.2453 1 1
Echinococcus multilocularis SH2 motif 0.147 0.4484 0.4484
Brugia malayi Protein kinase domain containing protein 0.0983 0.1757 0.1757
Echinococcus granulosus fibroblast growth factor receptor 4 0.0983 0.1757 0.1757
Loa Loa (eye worm) hypothetical protein 0.147 0.4484 0.4484
Trypanosoma cruzi protein kinase, putative 0.0983 0.1757 1
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0983 0.1757 0.1757
Brugia malayi Immunoglobulin I-set domain containing protein 0.0983 0.1757 0.1757
Brugia malayi Protein kinase domain containing protein 0.2453 1 1
Plasmodium vivax protein kinase, putative 0.0983 0.1757 0.5
Echinococcus granulosus SH2 domain containing adapter protein F 0.147 0.4484 0.4484
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0983 0.1757 0.1757
Echinococcus multilocularis epidermal growth factor receptor 0.0983 0.1757 0.1757
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0983 0.1757 0.1757
Echinococcus granulosus epidermal growth factor receptor 0.0983 0.1757 0.1757
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.147 0.4484 0.4484
Brugia malayi SH2 domain containing protein 0.147 0.4484 0.4484
Echinococcus multilocularis activin receptor type 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Loa Loa (eye worm) TK/FAK protein kinase 0.0983 0.1757 0.1757
Mycobacterium tuberculosis Carboxylesterase LipT 0.0974 0.1706 0.5
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Echinococcus multilocularis SH2 domain containing adapter protein F 0.147 0.4484 0.4484
Loa Loa (eye worm) hypothetical protein 0.147 0.4484 0.4484
Echinococcus granulosus fatty acid amide hydrolase 1 0.1569 0.5042 0.5042
Loa Loa (eye worm) TK/FER protein kinase 0.2453 1 1
Schistosoma mansoni amidase 0.1569 0.5042 0.3985
Loa Loa (eye worm) serine/threonine protein kinase 0.0983 0.1757 0.1757
Echinococcus multilocularis NCK adaptor protein 0.147 0.4484 0.4484
Echinococcus multilocularis SH2 motif 0.147 0.4484 0.4484
Brugia malayi hypothetical protein 0.2453 1 1
Echinococcus multilocularis protein kinase 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Onchocerca volvulus 0.147 0.4484 0.4484
Echinococcus granulosus tyrosine protein kinase Lyn 0.2453 1 1
Echinococcus granulosus tyrosine kinase 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Giardia lamblia Kinase 0.0983 0.1757 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.0983 0.1757 0.1757
Loa Loa (eye worm) TK protein kinase 0.2453 1 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.147 0.4484 0.4484
Echinococcus multilocularis tyrosine protein kinase csk 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0983 0.1757 0.1757
Loa Loa (eye worm) TK/FER protein kinase 0.2453 1 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.0983 0.1757 0.1757
Loa Loa (eye worm) STAT protein 0.147 0.4484 0.4484
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0983 0.1757 0.1757
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.147 0.4484 0.4484
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0983 0.1757 0.1757
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0983 0.1757 0.1757
Toxoplasma gondii STE kinase 0.0983 0.1757 0.5
Echinococcus granulosus tyrosine protein kinase csk 0.0983 0.1757 0.1757
Echinococcus multilocularis tyrosine protein kinase Fgr 0.2453 1 1
Schistosoma mansoni hypothetical protein 0.147 0.4484 0.3309
Echinococcus multilocularis suppressor of cytokine signaling 7 0.147 0.4484 0.4484
Trypanosoma cruzi protein kinase, putative 0.0983 0.1757 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.2453 1 1
Echinococcus multilocularis SH2 motif 0.147 0.4484 0.4484
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.147 0.4484 0.4484
Plasmodium vivax tyrosine kinase-like protein, putative 0.0983 0.1757 0.5
Brugia malayi Sex muscle abnormal protein 5 0.147 0.4484 0.4484
Echinococcus granulosus activated cdc42 kinase 1 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Loa Loa (eye worm) TK/FER protein kinase 0.0983 0.1757 0.1757
Brugia malayi Protein kinase domain containing protein 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0983 0.1757 0.1757
Echinococcus granulosus tensin C1 domain containing phosphatase 0.147 0.4484 0.4484
Echinococcus granulosus natriuretic peptide receptor 1 0.0983 0.1757 0.1757
Schistosoma mansoni tyrosine-protein kinase zap-70 0.147 0.4484 0.3309
Brugia malayi Protein kinase domain containing protein 0.0983 0.1757 0.1757
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2453 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0983 0.1757 0.1757
Trypanosoma brucei Flagellum attachment zone protein 20 0.0983 0.1757 1
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0983 0.1757 1
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.147 0.4484 0.4484
Brugia malayi SH2 domain containing protein 0.147 0.4484 0.4484
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.147 0.4484 0.4484
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0983 0.1757 0.1757
Echinococcus granulosus N chimaerin 0.147 0.4484 0.4484
Echinococcus granulosus fatty acid amide hydrolase 1 0.1569 0.5042 0.5042
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.2453 1 1
Brugia malayi Protein kinase domain containing protein 0.0983 0.1757 0.1757
Echinococcus multilocularis protein kinase 0.0983 0.1757 0.1757
Brugia malayi SH2 domain containing protein 0.2453 1 1
Loa Loa (eye worm) hypothetical protein 0.0983 0.1757 0.1757
Echinococcus granulosus tyrosine protein kinase 0.0983 0.1757 0.1757
Trichomonas vaginalis AGC family protein kinase 0.0983 0.1757 1
Echinococcus granulosus suppressor of cytokine signaling 6 0.147 0.4484 0.4484
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2453 1 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.2453 1 1
Brugia malayi Protein kinase domain containing protein 0.0983 0.1757 0.1757
Schistosoma mansoni tensin 0.147 0.4484 0.3309
Onchocerca volvulus Tyrosine kinase homolog 0.0983 0.1757 0.1757
Brugia malayi Tyrosine-protein kinase abl-1 0.2453 1 1
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0983 0.1757 1
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.147 0.4484 0.4484
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.2453 1 1
Brugia malayi Protein kinase domain containing protein 0.0983 0.1757 0.1757
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1569 0.5042 0.5042
Echinococcus multilocularis SH2 domain containing protein 7 0.147 0.4484 0.4484
Plasmodium vivax tyrosine kinase-like protein, putative 0.0983 0.1757 0.5
Echinococcus granulosus tyrosine kinase 0.2453 1 1
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Brugia malayi Protein kinase domain containing protein 0.0983 0.1757 0.1757
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0983 0.1757 0.1757
Brugia malayi Receptor family ligand binding region containing protein 0.0983 0.1757 0.1757
Echinococcus multilocularis FL cytokine receptor 0.0983 0.1757 0.1757
Echinococcus multilocularis tyrosine protein kinase ABL1 0.2453 1 1
Schistosoma mansoni nck2/grb4 0.147 0.4484 0.3309
Loa Loa (eye worm) TK/FER protein kinase 0.0983 0.1757 0.1757
Echinococcus granulosus SHC transforming protein 3 0.147 0.4484 0.4484
Loa Loa (eye worm) RGC/RGC protein kinase 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0983 0.1757 0.1757
Echinococcus multilocularis protein tyrosine kinase 0.0983 0.1757 0.1757
Loa Loa (eye worm) TK/FER protein kinase 0.2453 1 1
Onchocerca volvulus 0.0983 0.1757 0.1757
Loa Loa (eye worm) TK/FER protein kinase 0.2453 1 1
Onchocerca volvulus 0.0983 0.1757 0.1757
Leishmania major protein kinase, putative 0.0983 0.1757 1
Brugia malayi Protein kinase domain containing protein 0.0983 0.1757 0.1757
Echinococcus multilocularis c src tyrosine kinase 0.2453 1 1
Brugia malayi Protein kinase domain containing protein 0.0983 0.1757 0.1757
Echinococcus multilocularis SHC transforming protein 3 0.147 0.4484 0.4484
Loa Loa (eye worm) SH2 domain-containing protein 0.147 0.4484 0.4484
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.147 0.4484 0.4484
Brugia malayi SH2 domain containing protein 0.147 0.4484 0.4484
Loa Loa (eye worm) TK/EGFR protein kinase 0.0983 0.1757 0.1757
Trichomonas vaginalis conserved hypothetical protein 0.0983 0.1757 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.2453 1 1
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Echinococcus multilocularis tyrosine kinase 0.2453 1 1
Echinococcus multilocularis suppressor of cytokine signaling 6 0.147 0.4484 0.4484
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.2453 1 1
Echinococcus granulosus signal transduction protein lnk realted 0.147 0.4484 0.4484
Brugia malayi Furin-like cysteine rich region family protein 0.0983 0.1757 0.1757
Echinococcus granulosus ephrin type A receptor 4 A 0.0983 0.1757 0.1757
Schistosoma mansoni signal transduction protein lnk-related 0.147 0.4484 0.3309
Loa Loa (eye worm) hypothetical protein 0.147 0.4484 0.4484
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Toxoplasma gondii protein kinase domain-containing protein 0.0983 0.1757 0.5
Onchocerca volvulus 0.147 0.4484 0.4484
Loa Loa (eye worm) hypothetical protein 0.147 0.4484 0.4484
Loa Loa (eye worm) SRC-1 0.2453 1 1
Brugia malayi Tyrosine-protein kinase PR2 0.0983 0.1757 0.1757
Loa Loa (eye worm) TK/DDR protein kinase 0.0983 0.1757 0.1757
Onchocerca volvulus 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Echinococcus granulosus SH2 motif 0.147 0.4484 0.4484
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0983 0.1757 0.1757
Echinococcus multilocularis tyrosine protein kinase Abl 0.2453 1 1
Schistosoma mansoni shc transforming protein 0.147 0.4484 0.3309
Echinococcus multilocularis activated cdc42 kinase 1 0.0983 0.1757 0.1757
Onchocerca volvulus 0.0983 0.1757 0.1757
Entamoeba histolytica protein kinase, putative 0.147 0.4484 0.3309
Echinococcus granulosus tyrosine protein kinase Srms 0.2453 1 1
Echinococcus multilocularis integrin linked protein kinase 0.0983 0.1757 0.1757
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0983 0.1757 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.147 0.4484 0.4484
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Brugia malayi hypothetical protein 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0983 0.1757 0.1757
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0983 0.1757 0.1757
Brugia malayi SH2 domain containing protein 0.147 0.4484 0.4484
Loa Loa (eye worm) TK protein kinase 0.0983 0.1757 0.1757
Schistosoma mansoni tyrosine kinase 0.2453 1 1
Giardia lamblia Kinase, NEK 0.0983 0.1757 0.5
Brugia malayi Protein kinase domain containing protein 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0983 0.1757 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0983 0.1757 0.1757
Echinococcus granulosus hypothetical protein 0.147 0.4484 0.4484
Loa Loa (eye worm) RGC/RGC protein kinase 0.0983 0.1757 0.1757
Loa Loa (eye worm) TK/FER protein kinase 0.0983 0.1757 0.1757
Loa Loa (eye worm) SH2 domain-containing protein 0.147 0.4484 0.4484
Onchocerca volvulus 0.2453 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.2453 1 1
Loa Loa (eye worm) hypothetical protein 0.0983 0.1757 0.1757
Echinococcus granulosus tyrosine protein kinase pr2 0.0983 0.1757 0.1757
Loa Loa (eye worm) TK/Met protein kinase 0.0983 0.1757 0.1757
Schistosoma mansoni tensin-related 0.147 0.4484 0.3309
Trichomonas vaginalis protein tyrosine kinase, putative 0.0983 0.1757 1
Loa Loa (eye worm) TK protein kinase 0.0983 0.1757 0.1757
Trichomonas vaginalis conserved hypothetical protein 0.0983 0.1757 1
Onchocerca volvulus 0.0983 0.1757 0.1757
Loa Loa (eye worm) TK/EPH protein kinase 0.0983 0.1757 0.1757
Echinococcus granulosus receptor type guanylyl cyclase 0.0983 0.1757 0.1757
Brugia malayi hypothetical protein 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Loa Loa (eye worm) TK/ABL protein kinase 0.2453 1 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0983 0.1757 0.1757
Echinococcus granulosus integrin linked protein kinase 0.0983 0.1757 0.1757
Trichomonas vaginalis TKL family protein kinase 0.0983 0.1757 1
Trichomonas vaginalis conserved hypothetical protein 0.0983 0.1757 1
Loa Loa (eye worm) hypothetical protein 0.147 0.4484 0.4484
Loa Loa (eye worm) hypothetical protein 0.147 0.4484 0.4484
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0983 0.1757 0.5
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.2453 1 1
Loa Loa (eye worm) hypothetical protein 0.0983 0.1757 0.1757
Loa Loa (eye worm) TK/ACK protein kinase 0.0983 0.1757 0.1757
Loa Loa (eye worm) RGC/RGC protein kinase 0.0983 0.1757 0.1757

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 7.8 M Concentration required to relax phenylephrine-precontracted aortic rings by 50% in endothelium intact rat aorta ChEMBL. 9703467
ED50 (functional) = 9.8 M Concentration required to relax phenylephrine-precontracted aortic rings by 50% in endothelium denuded rabbit aorta ChEMBL. 9703467
Ki (binding) = 5.5 Binding affinity to Muscarinic acetylcholine receptor M2 by measuring its ability to displace [3H]-N-methylscopolamine binding in rat heart ChEMBL. 9703467
Ki (binding) = 5.6 Binding affinity to Muscarinic acetylcholine receptor M3 by measuring its ability to displace [3H]-N-methylscopolamine binding in rat submandibulary gland ChEMBL. 9703467
Ki (binding) = 6.1 Binding affinity to Muscarinic acetylcholine receptor M1 by measuring its ability to displace [3H]-pirenzepine from rat cerebral cortex ChEMBL. 9703467
Log Ki (binding) = 5.5 Binding affinity to Muscarinic acetylcholine receptor M2 by measuring its ability to displace [3H]-N-methylscopolamine binding in rat heart ChEMBL. 9703467
Log Ki (binding) = 5.6 Binding affinity to Muscarinic acetylcholine receptor M3 by measuring its ability to displace [3H]-N-methylscopolamine binding in rat submandibulary gland ChEMBL. 9703467
Log Ki (binding) = 6.1 Binding affinity to Muscarinic acetylcholine receptor M1 by measuring its ability to displace [3H]-pirenzepine from rat cerebral cortex ChEMBL. 9703467
Selectivity ratio (binding) = 0.66 Inhibitory selectivity for Muscarinic receptors M3 and M2 ChEMBL. 9703467
Selectivity ratio (binding) = 3 Inhibitory selectivity for Muscarinic receptors M3 and M1 ChEMBL. 9703467
Selectivity ratio (binding) = 4.5 Inhibitory selectivity for Muscarinic receptors M2 and M1 ChEMBL. 9703467

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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