Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | loechrig isoform VII | 0.0368 | 0.782 | 0.7454 |
Onchocerca volvulus | Alicorn homolog | 0.0105 | 0.1045 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.012 | 0.1437 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0453 | 1 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/AMPK protein kinase | 0.0253 | 0.4842 | 0.3976 |
Echinococcus multilocularis | 5' AMP activated protein kinase catalytic | 0.0253 | 0.4842 | 0.6192 |
Toxoplasma gondii | 5'-AMP-activated protein kinase subunit beta-1 family protein, putative | 0.0071 | 0.0166 | 0.5 |
Brugia malayi | EST embl|AI107989|AI107989 comes from the 3' UTR, putative | 0.0253 | 0.4842 | 0.3976 |
Trypanosoma cruzi | SNF1-related protein kinase regulatory subunit beta, putative | 0.012 | 0.1437 | 0.5 |
Echinococcus granulosus | AMPK beta subunit | 0.012 | 0.1437 | 0.1838 |
Echinococcus granulosus | 5' AMP activated protein kinase subunit gamma | 0.0368 | 0.782 | 1 |
Echinococcus multilocularis | 5' AMP activated protein kinase subunit gamma | 0.0368 | 0.782 | 1 |
Trypanosoma brucei | 5'-AMP-activated protein kinase subunit beta | 0.012 | 0.1437 | 0.5 |
Schistosoma mansoni | protein kinase subunit beta | 0.012 | 0.1437 | 0.1838 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0253 | 0.4842 | 0.6192 |
Echinococcus granulosus | 5' AMP activated protein kinase catalytic | 0.0253 | 0.4842 | 0.6192 |
Echinococcus multilocularis | 5' AMP activated protein kinase subunit gamma | 0.0338 | 0.7053 | 0.9019 |
Echinococcus multilocularis | AMPK beta subunit | 0.012 | 0.1437 | 0.1838 |
Brugia malayi | loechrig isoform VII | 0.0368 | 0.782 | 0.7454 |
Trypanosoma cruzi | 5'-AMP-activated protein kinase subunit beta, putative | 0.012 | 0.1437 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0441 | 0.9691 | 0.964 |
Schistosoma mansoni | protein kinase subunit gamma | 0.0368 | 0.782 | 1 |
Giardia lamblia | 5-AMP-activated protein kinase, gamma-1 subunit | 0.0368 | 0.782 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 100000 nM | Inhibition of human recombinant carbonic anhydrase-2-mediated CO2 hydration by stopped-flow assay | ChEMBL. | 24299463 |
Ki (binding) | > 100000 nM | Inhibition of human recombinant carbonic anhydrase-1-mediated CO2 hydration by stopped-flow assay | ChEMBL. | 24299463 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.