Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0173 | 0.3376 | 0.3376 |
Brugia malayi | steroid hormone receptor | 0.0327 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0173 | 0.3376 | 0.3376 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0327 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0327 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0327 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0173 | 0.3376 | 0.3376 |
Schistosoma mansoni | nuclear receptor | 0.0154 | 0.2582 | 0.2582 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0327 | 1 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.0094 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0327 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0327 | 1 | 1 |
Toxoplasma gondii | methionine aminopeptidase 2, putative | 0.0094 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0154 | 0.2582 | 0.2582 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.3376 | 0.3376 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.2582 | 0.2582 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0327 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0154 | 0.2582 | 0.2582 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0327 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0327 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0327 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0327 | 1 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0154 | 0.2582 | 0.2582 |
Brugia malayi | conserved hypotetical protein | 0.0154 | 0.2582 | 0.2582 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0327 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0327 | 1 | 1 |
Plasmodium vivax | methionine aminopeptidase 2, putative | 0.0094 | 0 | 0.5 |
Brugia malayi | nuclear receptor RXR | 0.0154 | 0.2582 | 0.2582 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0327 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0327 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0327 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0173 | 0.3376 | 0.3376 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0094 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | DR-78 | 0.0154 | 0.2582 | 0.2582 |
Schistosoma mansoni | thyroid hormone receptor | 0.0327 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0327 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0154 | 0.2582 | 0.2582 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0154 | 0.2582 | 0.2582 |
Entamoeba histolytica | methionine aminopeptidase, putative | 0.0094 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0327 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0154 | 0.2582 | 0.2582 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0327 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0327 | 1 | 1 |
Brugia malayi | ecdysone receptor | 0.0154 | 0.2582 | 0.2582 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0154 | 0.2582 | 0.2582 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0327 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0327 | 1 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0094 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0154 | 0.2582 | 0.2582 |
Brugia malayi | nuclear receptor RXR | 0.0173 | 0.3376 | 0.3376 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.2582 | 0.2582 |
Brugia malayi | nuclear hormone receptor | 0.0154 | 0.2582 | 0.2582 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0327 | 1 | 1 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0154 | 0.2582 | 0.2582 |
Brugia malayi | hypothetical protein | 0.0154 | 0.2582 | 0.2582 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0173 | 0.3376 | 0.3376 |
Onchocerca volvulus | 0.0154 | 0.2582 | 0.2582 | |
Schistosoma mansoni | coup transcription factor | 0.0327 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0327 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0173 | 0.3376 | 0.3376 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0154 | 0.2582 | 0.2582 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0327 | 1 | 1 |
Plasmodium falciparum | methionine aminopeptidase 2 | 0.0094 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.3376 | 0.3376 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.3376 | 0.3376 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.2582 | 0.2582 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0154 | 0.2582 | 0.2582 |
Brugia malayi | nuclear receptor NHR-88 | 0.0154 | 0.2582 | 0.2582 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0327 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0327 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0327 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0327 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0327 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0154 | 0.2582 | 0.2582 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0154 | 0.2582 | 0.2582 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0154 | 0.2582 | 0.2582 |
Onchocerca volvulus | 0.0154 | 0.2582 | 0.2582 | |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.2582 | 0.2582 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0327 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0327 | 1 | 1 |
Leishmania major | methionine aminopeptidase 2, putative | 0.0094 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0154 | 0.2582 | 0.2582 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0327 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0327 | 1 | 1 |
Trypanosoma brucei | methionine aminopeptidase 2, putative | 0.0094 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0154 | 0.2582 | 0.2582 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0154 | 0.2582 | 0.2582 |
Brugia malayi | hypothetical protein | 0.0173 | 0.3376 | 0.3376 |
Brugia malayi | nuclear hormone receptor | 0.0327 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0327 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.2582 | 0.2582 |
Schistosoma mansoni | nuclear hormone receptor | 0.0154 | 0.2582 | 0.2582 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0154 | 0.2582 | 0.2582 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.3376 | 0.3376 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.2582 | 0.2582 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0173 | 0.3376 | 0.3376 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0154 | 0.2582 | 0.2582 |
Onchocerca volvulus | 0.0327 | 1 | 1 | |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0327 | 1 | 1 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0154 | 0.2582 | 0.2582 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0327 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0327 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0327 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0327 | 1 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0094 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0154 | 0.2582 | 0.2582 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0327 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.3376 | 0.3376 |
Schistosoma mansoni | zinc finger protein | 0.0154 | 0.2582 | 0.2582 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0173 | 0.3376 | 0.3376 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0094 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.2582 | 0.2582 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0094 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.2582 | 0.2582 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0154 | 0.2582 | 0.2582 |
Brugia malayi | tailless protein | 0.0154 | 0.2582 | 0.2582 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0154 | 0.2582 | 0.2582 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0154 | 0.2582 | 0.2582 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.2582 | 0.2582 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.2582 | 0.2582 |
Giardia lamblia | Methionine aminopeptidase | 0.0094 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0327 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0327 | 1 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0154 | 0.2582 | 0.2582 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0154 | 0.2582 | 0.2582 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.2582 | 0.2582 |
Schistosoma mansoni | nuclear hormone receptor | 0.0154 | 0.2582 | 0.2582 |
Schistosoma mansoni | nuclear receptor | 0.0154 | 0.2582 | 0.2582 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0154 | 0.2582 | 0.2582 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.2582 | 0.2582 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0327 | 1 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0094 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0327 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0154 | 0.2582 | 0.2582 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.2582 | 0.2582 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 25 % | Displacement of [3H]CP-55,940 from human recombinant cannabinoid CB2 receptor expressed in CHO cells at 1 uM | ChEMBL. | 24139843 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.