Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kallikrein-related peptidase 7 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | kallikrein-related peptidase 7 | 181 aa | 186 aa | 32.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | animal heme peroxidase | 0.0104 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0104 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0104 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0098 | 0 | 0.5 |
Onchocerca volvulus | 0.0104 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0104 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0104 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 1 | 1 |
Onchocerca volvulus | 0.0104 | 1 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0104 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0104 | 1 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0098 | 0 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0104 | 1 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0104 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0104 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0104 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0104 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0104 | 1 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0104 | 1 | 1 |
Onchocerca volvulus | 0.0104 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0104 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0104 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0104 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0104 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0104 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0098 | 0 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0104 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0104 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0104 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0098 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 28.7 uM | Inhibition of human recombinant KLK7 expressed in baculovirus-infected insect cell system using Abz-KLYSSKQ-Eddnp as substrate incubated for 5 mins prior to substrate addition by FRET assay | ChEMBL. | 24900785 |
IC50 (binding) | = 356.6 uM | Inhibition of human recombinant KLK5 expressed in baculovirus-infected insect cell system using Abz-KLRSSKQ-Eddnp as substrate incubated for 5 mins prior to substrate addition by FRET assay | ChEMBL. | 24900785 |
Inhibition (binding) | Inhibition of human KLK6 at 1 to 500 uM after 5 mins by spectrophotometry | ChEMBL. | 24900785 | |
Inhibition (binding) | Inhibition of human KLK1 at 1 to 500 uM after 5 mins by spectrophotometry | ChEMBL. | 24900785 | |
Ki (binding) | = 18.4 uM | Competitive inhibition of human recombinant KLK7 expressed in baculovirus-infected insect cell system using Abz-KLYSSKQ-Eddnp as substrate incubated for 5 mins prior to substrate addition by Lineweaver-Burk plot analysis | ChEMBL. | 24900785 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.