Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | multiple endocrine neoplasia I | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | dnaJ subfamily B | Get druggable targets OG5_133913 | All targets in OG5_133913 |
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_133913 | All targets in OG5_133913 |
Echinococcus granulosus | dnaJ subfamily B | Get druggable targets OG5_133913 | All targets in OG5_133913 |
Schistosoma japonicum | Menin, putative | Get druggable targets OG5_133913 | All targets in OG5_133913 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.0538 | 1 | 1 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0538 | 1 | 1 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0538 | 1 | 1 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0538 | 1 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0108 | 0.004 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0538 | 1 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0108 | 0.004 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.0308 | 0.5682 | 0.5653 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0068 | 0.0068 |
Leishmania major | N-myristoyl transferase, putative | 0.0538 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.6316 | 0.6276 |
Schistosoma mansoni | hypothetical protein | 0.0494 | 0.9173 | 0.9173 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0594 | 0.0594 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.0308 | 0.5682 | 0.5653 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0557 | 0.0557 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.0342 | 0.6316 | 1 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0538 | 1 | 0.5 |
Trypanosoma brucei | N-myristoyltransferase | 0.0538 | 1 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.0594 | 0.053 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.0538 | 1 | 1 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.0342 | 0.6316 | 0.6316 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0538 | 1 | 0.5 |
Echinococcus multilocularis | lysosomal protective protein | 0.0342 | 0.6316 | 0.6291 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0538 | 1 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.0557 | 0.0454 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0594 | 0.0594 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.0557 | 0.0457 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.1139 | 0.5 |
Schistosoma mansoni | N-myristoyltransferase | 0.0538 | 1 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.0594 | 0.053 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.1287 | 0.1287 |
Giardia lamblia | CDC72 | 0.0538 | 1 | 0.5 |
Schistosoma mansoni | lysosomal protective protein precursor (cathepsin A) (carboxypeptidase | 0.0034 | 0.054 | 0.054 |
Brugia malayi | Serine carboxypeptidase F41C3.5 precursor | 0.0342 | 0.6316 | 0.6277 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0538 | 1 | 0.5 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0353 | 0.6538 | 0.652 |
Echinococcus granulosus | dnaJ subfamily B | 0.0494 | 0.9173 | 0.9167 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0494 | 0.9173 | 0.9167 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.0342 | 0.6316 | 0.6316 |
Echinococcus granulosus | lysosomal protective protein | 0.0342 | 0.6316 | 0.6291 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 195 nM | Inhibition of human His-tagged menin-biotinylated MLL (4 to 15) interaction after 1 hr by HTRF assay | ChEMBL. | 24472025 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.