Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Mastin | 0.0378 | 0.3449 | 0.3449 |
Schistosoma mansoni | alpha-glucosidase | 0.012 | 0.0887 | 0.0887 |
Trypanosoma brucei | protein kinase, putative | 0.1037 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0378 | 0.3449 | 0.3449 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0067 | 0.0358 | 0.0358 |
Onchocerca volvulus | 0.0378 | 0.3449 | 1 | |
Brugia malayi | Trypsin family protein | 0.0378 | 0.3449 | 0.3449 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0378 | 0.3449 | 0.3449 |
Schistosoma mansoni | hypothetical protein | 0.0378 | 0.3449 | 0.3449 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0378 | 0.3449 | 0.3449 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0378 | 0.3449 | 0.3449 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0046 | 0.0046 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.014 | 0.1081 | 0.1081 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0378 | 0.3449 | 0.3449 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.014 | 0.1081 | 0.1081 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0378 | 0.3449 | 0.3449 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1037 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.1037 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0209 | 0.0209 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0378 | 0.3449 | 0.3449 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.1037 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.0378 | 0.3449 | 0.3449 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0378 | 0.3449 | 0.3449 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0378 | 0.3449 | 0.3449 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0378 | 0.3449 | 0.3449 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.014 | 0.1081 | 0.1081 |
Loa Loa (eye worm) | hypothetical protein | 0.0378 | 0.3449 | 0.3449 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.014 | 0.1081 | 0.1081 |
Loa Loa (eye worm) | hypothetical protein | 0.0378 | 0.3449 | 0.3449 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0209 | 0.0209 |
Onchocerca volvulus | 0.0378 | 0.3449 | 1 | |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0067 | 0.0358 | 0.0358 |
Echinococcus multilocularis | enteropeptidase | 0.0378 | 0.3449 | 0.3449 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0378 | 0.3449 | 0.3449 |
Brugia malayi | Trypsin family protein | 0.0378 | 0.3449 | 0.3449 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0067 | 0.0358 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0378 | 0.3449 | 0.3449 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0378 | 0.3449 | 0.3449 |
Loa Loa (eye worm) | hypothetical protein | 0.0378 | 0.3449 | 0.3449 |
Brugia malayi | hypothetical protein | 0.0378 | 0.3449 | 0.3449 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.1037 | 1 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0067 | 0.0358 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0378 | 0.3449 | 0.3449 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0378 | 0.3449 | 0.3449 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.1037 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.1037 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0378 | 0.3449 | 0.3449 |
Onchocerca volvulus | 0.0378 | 0.3449 | 1 | |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0067 | 0.0358 | 0.0358 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0378 | 0.3449 | 0.3449 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.014 | 0.1081 | 0.1081 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0067 | 0.0358 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.1037 | 1 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0044 | 0.0129 | 0.5 |
Echinococcus multilocularis | Mastin | 0.0378 | 0.3449 | 0.3449 |
Onchocerca volvulus | 0.0378 | 0.3449 | 1 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.1037 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0378 | 0.3449 | 0.3449 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0378 | 0.3449 | 0.3449 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0044 | 0.0129 | 0.0129 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.1037 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0209 | 0.0209 |
Onchocerca volvulus | 0.0378 | 0.3449 | 1 | |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0067 | 0.0358 | 0.0358 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0044 | 0.0129 | 0.0129 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0378 | 0.3449 | 0.3449 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.1037 | 1 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0067 | 0.0358 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1037 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1037 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1037 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0046 | 0.0046 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0378 | 0.3449 | 0.3449 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0067 | 0.0358 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0378 | 0.3449 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0044 | 0.0129 | 0.5 |
Brugia malayi | Probable ClpP-like protease | 0.0067 | 0.0358 | 0.0358 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0378 | 0.3449 | 0.3449 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.1037 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.012 | 0.0887 | 0.0887 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0378 | 0.3449 | 0.3449 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0378 | 0.3449 | 0.3449 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0358 | 0.0358 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0378 | 0.3449 | 0.3449 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.1037 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.0378 | 0.3449 | 0.3449 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0378 | 0.3449 | 0.3449 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0378 | 0.3449 | 0.3449 |
Schistosoma mansoni | hypothetical protein | 0.0378 | 0.3449 | 0.3449 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1037 | 1 | 1 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0378 | 0.3449 | 0.3449 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0067 | 0.0358 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.1037 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0209 | 0.0209 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0046 | 0.0046 |
Loa Loa (eye worm) | trypsin family protein | 0.0378 | 0.3449 | 0.3449 |
Loa Loa (eye worm) | hypothetical protein | 0.0378 | 0.3449 | 0.3449 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0378 | 0.3449 | 0.3449 |
Giardia lamblia | Kinase, CMGC MAPK | 0.1037 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0378 | 0.3449 | 0.3449 |
Onchocerca volvulus | 0.0378 | 0.3449 | 1 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0378 | 0.3449 | 0.3449 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0067 | 0.0358 | 0.0358 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1037 | 1 | 1 |
Echinococcus granulosus | enteropeptidase | 0.0378 | 0.3449 | 0.3449 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0067 | 0.0358 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0378 | 0.3449 | 0.3449 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of FAAH (unknown origin) at 1 uM | ChEMBL. | 24900793 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.