Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0205 | 0.5532 |
Onchocerca volvulus | 0.1086 | 1 | 1 | |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0071 | 0.0371 | 1 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.1054 | 0.9699 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.1086 | 1 | 1 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.1054 | 0.9699 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0071 | 0.0371 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0071 | 0.0371 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0205 | 0.5532 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.0371 | 1 |
Brugia malayi | acyl-CoA desaturase | 0.1054 | 0.9699 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.0371 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1054 | 0.9699 | 0.9699 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0205 | 0.5532 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0205 | 0.5532 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0071 | 0.0371 | 0.0371 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1054 | 0.9699 | 0.9699 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0205 | 0.5532 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0071 | 0.0371 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1086 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.0371 | 1 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.1054 | 0.9699 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0205 | 0.0212 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0205 | 0.0212 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.1086 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0205 | 0.5532 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0071 | 0.0371 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0205 | 0.5532 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0071 | 0.0371 | 1 |
Onchocerca volvulus | 0.1086 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of p38a MAPK (unknown origin) by radiometric assay | ChEMBL. | 24508134 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.