Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0221 | 0.312 | 0.2981 |
Trichomonas vaginalis | cyclins, putative | 0.0031 | 0.0198 | 0.0151 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0669 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0221 | 0.312 | 0.2981 |
Plasmodium vivax | protein kinase Crk2 | 0.0221 | 0.312 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0221 | 0.312 | 0.312 |
Plasmodium falciparum | protein kinase 5 | 0.0221 | 0.312 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0669 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0669 | 1 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0221 | 0.312 | 0.2981 |
Trichomonas vaginalis | cyclin B, putative | 0.0031 | 0.0198 | 0.0151 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0221 | 0.312 | 0.3087 |
Trichomonas vaginalis | cyclin B, putative | 0.0031 | 0.0198 | 0.0151 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0221 | 0.312 | 0.2981 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0221 | 0.312 | 0.2981 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0221 | 0.312 | 0.2981 |
Trichomonas vaginalis | cyclin A, putative | 0.0031 | 0.0198 | 0.0151 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0221 | 0.312 | 0.2981 |
Echinococcus granulosus | cyclin dependent kinase | 0.0221 | 0.312 | 0.2981 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0669 | 1 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0221 | 0.312 | 0.2981 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0669 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0221 | 0.312 | 0.312 |
Trichomonas vaginalis | cyclins, putative | 0.0031 | 0.0198 | 0.0151 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0669 | 1 | 1 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0221 | 0.312 | 0.2981 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0669 | 1 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0221 | 0.312 | 1 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0221 | 0.312 | 0.2981 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0669 | 1 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0221 | 0.312 | 0.2981 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0221 | 0.312 | 0.3087 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0669 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0198 | 0.0198 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0669 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0669 | 1 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0031 | 0.0198 | 0.0151 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0221 | 0.312 | 0.2981 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0669 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0198 | 0.0198 |
Trichomonas vaginalis | cyclin B, putative | 0.0031 | 0.0198 | 0.0151 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0221 | 0.312 | 0.2981 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0221 | 0.312 | 0.2981 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0221 | 0.312 | 0.2981 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0221 | 0.312 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0669 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0031 | 0.0198 | 0.0151 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0669 | 1 | 1 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0221 | 0.312 | 0.2981 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0221 | 0.312 | 0.2981 |
Trichomonas vaginalis | cyclins, putative | 0.0031 | 0.0198 | 0.0151 |
Brugia malayi | Protein kinase domain containing protein | 0.0221 | 0.312 | 0.2981 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.2992 | 0.2992 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0221 | 0.312 | 0.2981 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0669 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0669 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0669 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0221 | 0.312 | 0.3087 |
Brugia malayi | cell division control protein 2 homolog | 0.0221 | 0.312 | 0.2981 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0669 | 1 | 1 |
Onchocerca volvulus | 0.0031 | 0.0198 | 0.5 | |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0221 | 0.312 | 0.2981 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0669 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0669 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0221 | 0.312 | 0.312 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 98 % | Inhibition of Streptococcus pneumoniae MurF ligase using D-Ala-D-Ala as substrate assessed as residual activity at 250 uM after 15 mins by malachite green assay | ChEMBL. | 24384549 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.