Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0357 | 0.029 | 0.0206 |
Schistosoma mansoni | protein kinase | 0.8298 | 1 | 1 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.019 | 0.0085 | 0.0085 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.019 | 0.0085 | 0.0085 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.8298 | 1 | 1 |
Loa Loa (eye worm) | STE/STE7/MEK4 protein kinase | 0.019 | 0.0085 | 0.0085 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.8298 | 1 | 1 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.8298 | 1 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0357 | 0.029 | 0.5 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.8298 | 1 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0357 | 0.029 | 0.5 |
Schistosoma mansoni | kinase | 0.019 | 0.0085 | 0.0085 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0357 | 0.029 | 0.5 |
Onchocerca volvulus | Kinase homolog | 0.019 | 0.0085 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0357 | 0.029 | 0.029 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0076 | 0.0076 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC100 (functional) | ND 0 ug ml-1 | Inhibition against platelet aggregation(rabbit platelet-rich plasma),induced by arachidonic acid. | ChEMBL. | 10464014 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.