Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.15 | 0.5 | 0.5 |
Loa Loa (eye worm) | lipase | 0.15 | 0.5 | 0.5 |
Onchocerca volvulus | 0.15 | 0.5 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.15 | 0.5 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.15 | 0.5 | 0.5 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.15 | 0.5 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.15 | 0.5 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.15 | 0.5 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.15 | 0.5 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.15 | 0.5 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.15 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Reduction (functional) | = 0 % | Anthelmintic activity against mice, infected with parasite Nematospirodes dubius, at a dose of 125 (ppm in feed) | ChEMBL. | 1956049 |
Reduction (functional) | = 0 % | Anthelmintic activity against mice infected with parasite Hymenolepis nana at a dose of 125 ppm (in feed) | ChEMBL. | 1956049 |
Reduction (functional) | = 90 % | The compound was tested for anthelmintic activity against mice, infected with parasite Hymenolepis nana at a dose of 250(ppm in feed) | ChEMBL. | 1956049 |
Reduction (functional) | = 100 % | Anthelmintic activity against mice, infected with parasite Nematospirodes dubius, at a dose of 250(ppm in feed) | ChEMBL. | 1956049 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.