Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0023 | 0.0823 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0794 | 0.0794 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0085 | 0.5139 | 0.5139 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0013 | 0.0163 | 0.0155 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0823 | 0.0823 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0013 | 0.0163 | 0.0163 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0013 | 0.0163 | 0.0163 |
Brugia malayi | intermediate filament protein | 0.0023 | 0.0823 | 0.1461 |
Echinococcus multilocularis | lamin dm0 | 0.0023 | 0.0823 | 0.0823 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0147 | 0.9475 | 0.9466 |
Echinococcus granulosus | GPCR family 2 | 0.0013 | 0.0163 | 0.0163 |
Schistosoma mansoni | lamin | 0.0023 | 0.0823 | 0.0671 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.4077 | 0.4077 |
Echinococcus multilocularis | musashi | 0.0023 | 0.0823 | 0.0823 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0013 | 0.0163 | 0.0155 |
Echinococcus multilocularis | lamin | 0.0023 | 0.0823 | 0.0823 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0012 | 0.0084 | 0.0084 |
Echinococcus multilocularis | GPCR, family 2 | 0.0013 | 0.0163 | 0.0163 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0013 | 0.0163 | 0.0163 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.5139 | 0.5139 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0029 | 0.1242 | 0.229 |
Schistosoma mansoni | intermediate filament proteins | 0.0023 | 0.0823 | 0.0671 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0013 | 0.0163 | 0.0163 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0081 | 0.4881 | 0.4881 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0042 | 0.2172 | 0.4131 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0042 | 0.2172 | 0.4131 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0085 | 0.5139 | 0.5059 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0085 | 0.5139 | 0.5059 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0085 | 0.5139 | 0.5139 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0085 | 0.5139 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0023 | 0.0823 | 0.0823 |
Echinococcus granulosus | lamin dm0 | 0.0023 | 0.0823 | 0.0823 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0042 | 0.2172 | 0.2172 |
Onchocerca volvulus | 0.0023 | 0.0823 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2172 | 0.2172 |
Echinococcus granulosus | lamin | 0.0023 | 0.0823 | 0.0823 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.1242 | 0.1097 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0085 | 0.5139 | 0.5139 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0023 | 0.0823 | 0.0823 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1242 | 0.1242 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0163 | 0.0163 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0023 | 0.0823 | 0.1461 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.4631 | 0.4631 |
Schistosoma mansoni | lamin | 0.0023 | 0.0823 | 0.0671 |
Loa Loa (eye worm) | intermediate filament protein | 0.0023 | 0.0823 | 0.0823 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0013 | 0.0163 | 0.0163 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 50 uM | Antiparasitic activity against Trypanosoma brucei brucei BF427 assessed as growth inhibition by Alamar Blue assay | ChEMBL. | 24354316 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.