Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 5 | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, metabotropic 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog | 0.0084 | 0.0601 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.0038 | 0.0136 | 0.0136 |
Schistosoma mansoni | fad oxidoreductase | 0.0084 | 0.0601 | 0.038 |
Entamoeba histolytica | NAD(FAD)-dependent dehydrogenase, putative | 0.0084 | 0.0601 | 0.5 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0048 | 0.0229 | 0.3107 |
Leishmania major | hypothetical protein, conserved | 0.0084 | 0.0601 | 0.5 |
Echinococcus multilocularis | FAD dependent oxidoreductase domain containing protein | 0.0084 | 0.0601 | 0.0626 |
Giardia lamblia | Glycerol-3-phosphate dehydrogenase | 0.0084 | 0.0601 | 0.5 |
Brugia malayi | pyruvate dehydrogenase phosphatase regulatory subunit precursor | 0.0084 | 0.0601 | 0.8149 |
Chlamydia trachomatis | D-amino acid dehydrogenase | 0.0084 | 0.0601 | 0.5 |
Brugia malayi | dimethylglycine dehydrogenase, mitochondrial precursor, putative | 0.0084 | 0.0601 | 0.8149 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0089 | 0.0644 | 0.8736 |
Trypanosoma brucei | glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial | 0.0084 | 0.0601 | 0.5 |
Schistosoma mansoni | NAD dehydrogenase | 0.0084 | 0.0601 | 0.038 |
Entamoeba histolytica | anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative | 0.0084 | 0.0601 | 0.5 |
Loa Loa (eye worm) | glycerol-3-phosphate dehydrogenase | 0.0084 | 0.0601 | 0.0601 |
Toxoplasma gondii | hypothetical protein | 0.0084 | 0.0601 | 0.5 |
Onchocerca volvulus | Dimethylglycine dehydrogenase, mitochondrial homolog | 0.0084 | 0.0601 | 0.5 |
Trypanosoma cruzi | L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative | 0.0084 | 0.0601 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0082 | 0.0576 | 0.0355 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase (FAD-dependent), putative | 0.0084 | 0.0601 | 0.5 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase (FAD-dependent), putative | 0.0084 | 0.0601 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0601 | 0.0601 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0601 | 0.0601 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0927 | 0.9145 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0098 | 0.0737 | 0.0737 |
Trypanosoma brucei | FAD dependent oxidoreductase, putative | 0.0084 | 0.0601 | 0.5 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase, putative | 0.0084 | 0.0601 | 0.5 |
Echinococcus granulosus | FAD dependent oxidoreductase domain containing protein | 0.0084 | 0.0601 | 0.0626 |
Leishmania major | glycerol-3-phosphate dehydrogenase-like protein | 0.0084 | 0.0601 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0601 | 0.0601 |
Leishmania major | hypothetical protein, conserved | 0.0084 | 0.0601 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.012 | 0.0966 | 1 |
Echinococcus multilocularis | glycerol 3 phosphate dehydrogenase | 0.0084 | 0.0601 | 0.0626 |
Schistosoma mansoni | glycerol-3-phosphate dehydrogenase | 0.0084 | 0.0601 | 0.038 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0966 | 0.0966 |
Trypanosoma brucei | electron transfer flavoprotein-ubiquinone oxidoreductase, putative | 0.0084 | 0.0601 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0166 | 0.1426 | 0.1225 |
Plasmodium vivax | FAD-dependent glycerol-3-phosphate dehydrogenase, putative | 0.0084 | 0.0601 | 0.5 |
Schistosoma mansoni | ATP:guanidino kinase (Smc74) | 0.0084 | 0.0601 | 0.038 |
Schistosoma mansoni | fad oxidoreductase | 0.0084 | 0.0601 | 0.038 |
Brugia malayi | cDNA sequence BC016226 | 0.0084 | 0.0601 | 0.8149 |
Plasmodium falciparum | FAD-dependent glycerol-3-phosphate dehydrogenase, putative | 0.0084 | 0.0601 | 0.5 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 20 | 0.0084 | 0.0601 | 0.5 |
Echinococcus granulosus | glycerol 3 phosphate dehydrogenase | 0.0084 | 0.0601 | 0.0626 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0098 | 0.0737 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.012 | 0.0966 | 1 |
Trypanosoma cruzi | L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative | 0.0084 | 0.0601 | 0.5 |
Onchocerca volvulus | Putative fad oxidoreductase | 0.0084 | 0.0601 | 0.5 |
Brugia malayi | RE18450p | 0.0084 | 0.0601 | 0.8149 |
Trypanosoma cruzi | FAD dependent oxidoreductase, putative | 0.0084 | 0.0601 | 0.5 |
Toxoplasma gondii | FAD-dependent glycerol-3-phosphate dehydrogenase | 0.0084 | 0.0601 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0111 | 0.0873 | 0.0659 |
Trypanosoma brucei | glycerol-3-phosphate dehydrogenase (FAD-dependent), putative | 0.0084 | 0.0601 | 0.5 |
Trypanosoma brucei | L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative | 0.0084 | 0.0601 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 172 ml/min.kg | Intrinsic clearance in human liver microsomes | ChEMBL. | 24392688 |
IC50 (binding) | = 14.3 nM | Negative allosteric modulation of rat mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium flux after 16 to 24 hrs by FLIPR assay | ChEMBL. | 24392688 |
Ki (binding) | = 8.1 nM | Displacement of [3H]-MPEPy from human mGluR5 expressed in HEK293FT cells after 1 hr by liquid scintillation counting analysis | ChEMBL. | 24392688 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.