Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0097 | 0.4533 | 0.3091 | |
Trypanosoma cruzi | hexokinase, putative | 0.0097 | 0.4533 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.0097 | 0.4533 | 0.4533 |
Trypanosoma brucei | hexokinase, putative | 0.0097 | 0.4533 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0097 | 0.4533 | 0.4533 |
Leishmania major | hexokinase, putative | 0.0097 | 0.4533 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0097 | 0.4533 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0056 | 0.0056 |
Brugia malayi | Hexokinase family protein | 0.0097 | 0.4533 | 0.4533 |
Entamoeba histolytica | hexokinase 2 | 0.0097 | 0.4533 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0056 | 0.0056 |
Loa Loa (eye worm) | hexokinase | 0.0061 | 0.2087 | 0.2087 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0109 | 0.5381 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.2446 | 0.2446 |
Brugia malayi | hexokinase | 0.0097 | 0.4533 | 0.4533 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0109 | 0.5381 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.0097 | 0.4533 | 0.5 |
Toxoplasma gondii | hexokinase | 0.0097 | 0.4533 | 0.5 |
Onchocerca volvulus | 0.0097 | 0.4533 | 0.3091 | |
Brugia malayi | hexokinase type II | 0.0031 | 0.0056 | 0.0056 |
Trypanosoma brucei | hexokinase | 0.0097 | 0.4533 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0061 | 0.2087 | 0.2087 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0109 | 0.5381 | 1 |
Onchocerca volvulus | 0.0097 | 0.4533 | 0.3091 | |
Trypanosoma brucei | hexokinase | 0.0097 | 0.4533 | 0.5 |
Leishmania major | hexokinase, putative | 0.0097 | 0.4533 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0109 | 0.5381 | 0.5381 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0109 | 0.5381 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0109 | 0.5381 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0109 | 0.5381 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0109 | 0.5381 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0109 | 0.5381 | 0.5381 |
Trypanosoma cruzi | hexokinase, putative | 0.0097 | 0.4533 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.0097 | 0.4533 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0097 | 0.4533 | 0.4533 |
Plasmodium vivax | hexokinase, putative | 0.0097 | 0.4533 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 61 % | Inhibition of human tert transcriptional activity assessed as SEAP activity at 100 uM after 24 hrs by SEAP reporter assay | ChEMBL. | 24051300 |
Activity (binding) | = 83 % | Inhibition of human tert transcriptional activity assessed as SEAP activity at 10 uM after 24 hrs by SEAP reporter assay | ChEMBL. | 24051300 |
Activity (binding) | = 88 % | Inhibition of human tert transcriptional activity assessed as SEAP activity at 1 uM after 24 hrs by SEAP reporter assay | ChEMBL. | 24051300 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.