Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | dihydrofolate reductase | 187 aa | 202 aa | 29.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carbonic anhydrase II | 0.0231 | 0.4161 | 0.3048 |
Toxoplasma gondii | hypothetical protein | 0.0125 | 0.1601 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.0499 | 0.3119 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.1601 | 0.1601 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0231 | 0.4161 | 0.4161 |
Plasmodium falciparum | carbonic anhydrase | 0.0125 | 0.1601 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0231 | 0.4161 | 0.3048 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0125 | 0.1601 | 0.1601 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0125 | 0.1601 | 0.1601 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0125 | 0.1601 | 0.1601 |
Schistosoma mansoni | carbonic anhydrase | 0.0125 | 0.1601 | 0.1601 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0208 | 0.3604 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0208 | 0.3604 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0208 | 0.3604 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0208 | 0.3604 | 0.2385 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.0499 | 0.0499 |
Echinococcus granulosus | dihydrofolate reductase | 0.0208 | 0.3604 | 0.2385 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0079 | 0.0499 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0125 | 0.1601 | 0.1601 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0231 | 0.4161 | 0.4161 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0231 | 0.4161 | 0.4161 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0208 | 0.3604 | 0.3604 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0125 | 0.1601 | 0.1601 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0231 | 0.4161 | 0.4161 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.1601 | 0.1601 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.1601 | 0.1601 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0125 | 0.1601 | 0.1601 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.0499 | 0.0499 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.0499 | 0.0499 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0231 | 0.4161 | 0.4161 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0231 | 0.4161 | 0.4161 |
Leishmania major | carbonic anhydrase-like protein | 0.0231 | 0.4161 | 0.4161 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0231 | 0.4161 | 0.4161 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.0425 | 0.8871 | 0.8656 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0208 | 0.3604 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0208 | 0.3604 | 0.3604 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0231 | 0.4161 | 0.4161 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0231 | 0.4161 | 0.4161 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.0425 | 0.8871 | 0.8656 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0125 | 0.1601 | 0.1601 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0125 | 0.1601 | 0.1601 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.1601 | 0.1601 |
Brugia malayi | Dihydrofolate reductase | 0.0208 | 0.3604 | 0.3604 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0125 | 0.1601 | 0.1601 |
Schistosoma mansoni | dihydrofolate reductase | 0.0208 | 0.3604 | 0.3604 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.