TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 345.37 | Formula: C21H16FN3O
H donors: 2 H acceptors: 2 LogP: 4.32 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1nc2c([nH]1)cccc2c1ccccc1)NCc1ccccc1F
InChi: 1S/C21H16FN3O/c22-17-11-5-4-9-15(17)13-23-21(26)20-24-18-12-6-10-16(19(18)25-20)14-7-2-1-3-8-14/h1-12H,13H2,(H,23,26)(H,24,25)
InChiKey: ADRLYNCWOAOXPX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cannabinoid receptor 2 (macrophage)	Starlite/ChEMBL	References
Homo sapiens	cannabinoid receptor 1 (brain)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0006	0.0005	0.0005
Brugia malayi	hypothetical protein	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0015	0.0143	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Brugia malayi	Thioredoxin reductase	0.0059	0.08	0.08
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.0005	0.0005
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0006	0.0005	0.0005
Leishmania major	trypanothione reductase	0.0059	0.08	0.08
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0006	0.0005	0.0005
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0006	0.0005	0.0005
Schistosoma mansoni	biogenic amine receptor	0.0006	0.0005	0.0005
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0006	0.0005	0.0005
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0006	0.0005	0.0005
Schistosoma mansoni	neuropeptide receptor	0.0006	0.0005	0.0005
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.002	0.0224	0.0224
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.002	0.0224	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Schistosoma mansoni	myosin xvIII	0.0006	0.0005	0.0005
Echinococcus granulosus	tyrosine protein kinase Fyn	0.002	0.0223	0.0223
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0006	0.0005	0.0005
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0006	0.0005	0.0005
Echinococcus granulosus	dro:myosuppressin receptor	0.0006	0.0005	0.0005
Onchocerca volvulus		0.0006	0.0005	0.0005
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0006	0.0005	0.0005
Loa Loa (eye worm)	glutathione reductase	0.0059	0.08	0.08
Schistosoma mansoni	hypothetical protein	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Mycobacterium tuberculosis	Probable oxidoreductase	0.002	0.0224	0.2803
Onchocerca volvulus		0.0006	0.0005	0.0005
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.0005	0.0005
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0006	0.0005	0.0005
Schistosoma mansoni	adenoreceptor	0.0006	0.0005	0.0005
Entamoeba histolytica	protein kinase, putative	0.0016	0.0163	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.002	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Echinococcus granulosus	neuropeptide FF receptor 2	0.0006	0.0005	0.0005
Toxoplasma gondii	thioredoxin reductase	0.0059	0.08	1
Echinococcus granulosus	serotonin receptor	0.0006	0.0005	0.0005
Giardia lamblia	NADH oxidase lateral transfer candidate	0.002	0.0224	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Trypanosoma cruzi	trypanothione reductase, putative	0.002	0.0224	0.0224
Schistosoma mansoni	opsin-like receptor	0.0006	0.0005	0.0005
Echinococcus multilocularis	neuropeptide Y receptor	0.0006	0.0005	0.0005
Loa Loa (eye worm)	thioredoxin reductase	0.0059	0.08	0.08
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Brugia malayi	Serotonin receptor	0.0006	0.0005	0.0005
Schistosoma mansoni	biogenic amine receptor	0.0006	0.0005	0.0005
Brugia malayi	hypothetical protein	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Echinococcus granulosus	rhodopsin orphan GPCR	0.0006	0.0005	0.0005
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.002	0.0224	0.0224
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.002	0.0224	0.0224
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0006	0.0005	0.0005
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.002	0.0224	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.002	0.0223	0.0223
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0006	0.0005	0.0005
Echinococcus granulosus	tm gpcr rhodopsin	0.0006	0.0005	0.0005
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0006	0.0005	0.0005
Schistosoma mansoni	opsin-like receptor	0.0006	0.0005	0.0005
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0006	0.0005	0.0005
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.002	0.0224	1
Schistosoma mansoni	histamine h1 receptor	0.0006	0.0005	0.0005
Loa Loa (eye worm)	neuropeptide F receptor	0.0006	0.0005	0.0005
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0006	0.0005	0.0005
Echinococcus granulosus	biogenic amine 5HT receptor	0.0006	0.0005	0.0005
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0006	0.0005	0.0005
Echinococcus granulosus	tyrosine protein kinase Lyn	0.002	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Brugia malayi	neuropeptide F receptor	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Echinococcus multilocularis	serotonin receptor	0.0006	0.0005	0.0005
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.002	0.0224	0.0224
Brugia malayi	hypothetical protein	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Trichomonas vaginalis	glutathione reductase, putative	0.002	0.0224	1
Loa Loa (eye worm)	SRC-1	0.002	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Echinococcus multilocularis	sex peptide receptor	0.0006	0.0005	0.0005
Brugia malayi	glutathione reductase	0.0059	0.08	0.08
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0018	0.0193	0.0193
Plasmodium vivax	thioredoxin reductase, putative	0.0059	0.08	1
Brugia malayi	hypothetical protein	0.0006	0.0005	0.0005
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.002	0.0224	1
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.002	0.0224	0.2803
Echinococcus granulosus	neuropeptides capa receptor	0.0006	0.0005	0.0005
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0006	0.0005	0.0005
Onchocerca volvulus		0.0006	0.0005	0.0005
Trichomonas vaginalis	mercuric reductase, putative	0.002	0.0224	1
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.002	0.0224	0.2803
Echinococcus granulosus	fmrfamide receptor	0.0006	0.0005	0.0005
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0006	0.0005	0.0005
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0006	0.0005	0.0005
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0006	0.0005	0.0005
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.002	0.0224	0.2803
Echinococcus granulosus	tyrosine protein kinase HCK	0.0016	0.0163	0.0163
Echinococcus granulosus	neuropeptide receptor	0.0006	0.0005	0.0005
Echinococcus multilocularis	neuropeptides capa receptor	0.0006	0.0005	0.0005
Brugia malayi	hypothetical protein	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Echinococcus multilocularis	fmrfamide receptor	0.0006	0.0005	0.0005
Loa Loa (eye worm)	TYRA-2 protein	0.0006	0.0005	0.0005
Trypanosoma brucei	trypanothione reductase	0.0059	0.08	0.08
Onchocerca volvulus		0.0006	0.0005	0.0005
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.002	0.0224	0.0224
Onchocerca volvulus		0.0006	0.0005	0.0005
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0006	0.0005	0.0005
Echinococcus granulosus	neuropeptides capa receptor	0.0006	0.0005	0.0005
Schistosoma mansoni	biogenic amine receptor	0.0006	0.0005	0.0005
Brugia malayi	Dopamine receptor protein 2	0.0006	0.0005	0.0005
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Onchocerca volvulus		0.0006	0.0005	0.0005
Brugia malayi	hypothetical protein	0.0006	0.0005	0.0005
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0006	0.0005	0.0005
Echinococcus multilocularis	g protein coupled receptor	0.0006	0.0005	0.0005
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0006	0.0005	0.0005
Echinococcus granulosus	rhodopsin orphan GPCR	0.0006	0.0005	0.0005
Schistosoma mansoni	hypothetical protein	0.0006	0.0005	0.0005
Echinococcus multilocularis	family S10 non peptidase ue (S10 family)	0.0607	0.9004	0.9004
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0006	0.0005	0.0005
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.002	0.0224	0.0224
Echinococcus granulosus	family S10 non peptidase ue S10 family	0.0607	0.9004	0.9004
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0018	0.0185	0.0185
Schistosoma mansoni	growth hormone secretagogue receptor	0.0006	0.0005	0.0005
Plasmodium falciparum	thioredoxin reductase	0.002	0.0224	0.2803
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.002	0.0224	0.0224
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0006	0.0005	0.0005
Echinococcus granulosus	g-protein coupled receptor	0.0006	0.0005	0.0005
Echinococcus granulosus	tyrosine protein kinase Src64B	0.002	0.0223	0.0223
Echinococcus granulosus	rhodopsin orphan GPCR	0.0006	0.0005	0.0005
Onchocerca volvulus		0.0006	0.0005	0.0005
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.002	0.0224	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0015	0.0143	0.0143
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.002	0.0223	0.0223
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.002	0.0223	0.0223
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.002	0.0224	0.0224
Brugia malayi	Dopamine receptor	0.0006	0.0005	0.0005
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Echinococcus granulosus	tyrosine protein kinase Fyn	0.002	0.0223	0.0223
Brugia malayi	protein-tyrosine kinase	0.0018	0.0193	0.0193
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0006	0.0005	0.0005
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.002	0.0224	0.2803
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.002	0.0224	0.0224
Brugia malayi	G-protein coupled receptor	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Toxoplasma gondii	NADPH-glutathione reductase	0.002	0.0224	0.2803
Echinococcus granulosus	7TM GPCR rhodopsin	0.0006	0.0005	0.0005
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.002	0.0224	0.0224
Brugia malayi	Serotonin receptor	0.0006	0.0005	0.0005
Echinococcus granulosus	orexin receptor type 2	0.0006	0.0005	0.0005
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0006	0.0005	0.0005
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0006	0.0005	0.0005
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0006	0.0005	0.0005
Brugia malayi	GnHR receptor homolog	0.0006	0.0005	0.0005
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0006	0.0005	0.0005
Brugia malayi	SRC-1	0.002	0.0223	0.0223
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Onchocerca volvulus		0.0006	0.0005	0.0005
Echinococcus granulosus	somatostatin receptor	0.0006	0.0005	0.0005
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.0005	0.0005
Schistosoma mansoni	hypothetical protein	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.002	0.0224	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0006	0.0005	0.0005
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.002	0.0224	0.0224
Loa Loa (eye worm)	G-protein coupled receptor	0.0006	0.0005	0.0005
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.002	0.0224	0.0224
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.002	0.0223	0.0223
Plasmodium falciparum	thioredoxin reductase	0.0059	0.08	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0006	0.0005	0.0005
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0006	0.0005	0.0005
Echinococcus granulosus	tm gpcr rhodopsin	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Onchocerca volvulus		0.0006	0.0005	0.0005
Brugia malayi	G-protein coupled receptor	0.0006	0.0005	0.0005
Loa Loa (eye worm)	neuropeptide F receptor	0.0006	0.0005	0.0005
Schistosoma mansoni	tyrosine kinase	0.002	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Brugia malayi	hypothetical protein	0.0006	0.0005	0.0005
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.0005	0.0005
Schistosoma mansoni	neuropeptide F-like receptor	0.0006	0.0005	0.0005
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0018	0.0193	0.0193
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.0005	0.0005
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0006	0.0005	0.0005
Echinococcus multilocularis	neuropeptide Y receptor	0.0006	0.0005	0.0005
Echinococcus granulosus	rhodopsin orphan GPCR	0.0006	0.0005	0.0005
Schistosoma mansoni	neuropeptide receptor	0.0006	0.0005	0.0005
Plasmodium vivax	glutathione reductase, putative	0.0059	0.08	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Echinococcus multilocularis	neuropeptides capa receptor	0.0006	0.0005	0.0005
Schistosoma mansoni	amine GPCR	0.0006	0.0005	0.0005
Brugia malayi	follicle stimulating hormone receptor	0.0006	0.0005	0.0005
Schistosoma mansoni	tyrosine kinase	0.002	0.0223	0.0223
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0006	0.0005	0.0005
Brugia malayi	sulfakinin receptor protein	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Brugia malayi	hypothetical protein	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Brugia malayi	G protein-coupled receptor F59B2.13	0.0006	0.0005	0.0005
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0006	0.0005	0.0005
Schistosoma mansoni	amine GPCR	0.0006	0.0005	0.0005
Onchocerca volvulus		0.0006	0.0005	0.0005
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.002	0.0224	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Echinococcus multilocularis	neuropeptide receptor	0.0006	0.0005	0.0005
Echinococcus granulosus	tyrosine protein kinase Src42A	0.002	0.0223	0.0223
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0006	0.0005	0.0005
Echinococcus granulosus	g protein coupled receptor	0.0006	0.0005	0.0005
Brugia malayi	hypothetical protein	0.0006	0.0005	0.0005
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0006	0.0005	0.0005
Brugia malayi	RE15519p	0.0006	0.0005	0.0005
Echinococcus granulosus	allatostatin A receptor	0.0006	0.0005	0.0005
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0006	0.0005	0.0005
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0006	0.0005	0.0005
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.002	0.0223	0.0223
Echinococcus multilocularis	G protein coupled receptor 139	0.0006	0.0005	0.0005
Echinococcus granulosus	rhodopsin orphan GPCR	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Plasmodium falciparum	glutathione reductase	0.002	0.0224	0.2803
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0006	0.0005	0.0005
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Echinococcus granulosus	neuropeptide receptor	0.0006	0.0005	0.0005
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0059	0.08	0.08
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Echinococcus multilocularis	somatostatin receptor	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0006	0.0005	0.0005
Brugia malayi	hypothetical protein	0.0006	0.0005	0.0005
Echinococcus granulosus	rhodopsin orphan GPCR	0.0006	0.0005	0.0005
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Echinococcus multilocularis	neuropeptide receptor A26	0.0006	0.0005	0.0005
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0006	0.0005	0.0005
Onchocerca volvulus		0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.002	0.0224	0.0224
Echinococcus multilocularis	allatostatin A receptor	0.0006	0.0005	0.0005
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0018	0.0185	0.0185
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0006	0.0005	0.0005
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.002	0.0223	0.0223
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.002	0.0224	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Echinococcus granulosus	thioredoxin glutathione reductase	0.0059	0.08	0.08
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0018	0.0193	0.0193
Brugia malayi	AKH receptor	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.002	0.0224	0.2803
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.0005	0.0005
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0006	0.0005	0.0005
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.0005	0.0005
Onchocerca volvulus		0.0006	0.0005	0.0005
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0006	0.0005	0.0005
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.002	0.0224	1
Schistosoma mansoni	hypothetical protein	0.0006	0.0005	0.0005
Echinococcus granulosus	rhodopsin orphan GPCR	0.0006	0.0005	0.0005
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0006	0.0005	0.0005
Echinococcus granulosus	neuropeptide Y receptor	0.0006	0.0005	0.0005
Trypanosoma cruzi	trypanothione reductase, putative	0.0059	0.08	0.08
Schistosoma mansoni	lysosomal protective protein precursor (cathepsin A) (carboxypeptidase	0.0067	0.0915	0.0915
Loa Loa (eye worm)	melatonin receptor type 1A	0.0006	0.0005	0.0005
Brugia malayi	neuropeptide F receptor	0.0006	0.0005	0.0005
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.002	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Echinococcus granulosus	neuropeptide receptor A26	0.0006	0.0005	0.0005
Brugia malayi	Dopamine receptor protein 1	0.0006	0.0005	0.0005
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.002	0.0224	0.2803
Loa Loa (eye worm)	TK protein kinase	0.0016	0.0163	0.0163
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.002	0.0223	0.0223
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.002	0.0224	0.2803
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Echinococcus multilocularis	fmrfamide receptor	0.0006	0.0005	0.0005
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0006	0.0005	0.0005
Onchocerca volvulus		0.0006	0.0005	0.0005
Schistosoma mansoni	amine GPCR	0.0006	0.0005	0.0005
Echinococcus granulosus	7tm_1 domain containing protein	0.0006	0.0005	0.0005
Plasmodium falciparum	glutathione reductase	0.0059	0.08	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.002	0.0223	0.0223
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0006	0.0005	0.0005
Schistosoma mansoni	amine GPCR	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Brugia malayi	larval opioid receptor	0.0006	0.0005	0.0005
Echinococcus granulosus	neuropeptide Y receptor	0.0006	0.0005	0.0005
Brugia malayi	putative neuropeptide receptor	0.0006	0.0005	0.0005
Echinococcus granulosus	tyrosine protein kinase Blk	0.0018	0.0193	0.0193
Onchocerca volvulus		0.0006	0.0005	0.0005
Echinococcus granulosus	sex peptide receptor	0.0006	0.0005	0.0005
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.002	0.0224	0.0224
Brugia malayi	Melatonin receptor type 1A	0.0006	0.0005	0.0005
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Echinococcus multilocularis	neuropeptide receptor	0.0006	0.0005	0.0005
Echinococcus multilocularis	g protein coupled receptor	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.002	0.0224	0.2803
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0006	0.0005	0.0005
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0006	0.0005	0.0005
Brugia malayi	G protein-coupled receptor	0.0006	0.0005	0.0005
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0018	0.0193	0.0193
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.002	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Echinococcus granulosus	hypothetical protein	0.0006	0.0005	0.0005
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0006	0.0005	0.0005
Loa Loa (eye worm)	TK protein kinase	0.0018	0.0193	0.0193
Echinococcus multilocularis	g protein coupled receptor	0.0006	0.0005	0.0005
Echinococcus multilocularis	dro:myosuppressin receptor	0.0006	0.0005	0.0005
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0016	0.0163	0.0163
Echinococcus multilocularis	orexin receptor type 2	0.0006	0.0005	0.0005
Onchocerca volvulus		0.0006	0.0005	0.0005
Echinococcus granulosus	g protein coupled receptor	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Onchocerca volvulus		0.0006	0.0005	0.0005
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.002	0.0224	0.0224
Echinococcus multilocularis	serotonin receptor	0.0006	0.0005	0.0005
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0006	0.0005	0.0005
Schistosoma mansoni	amine GPCR	0.0006	0.0005	0.0005
Echinococcus granulosus	neuropeptide s receptor	0.0006	0.0005	0.0005
Schistosoma mansoni	neuropeptide receptor	0.0006	0.0005	0.0005
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.002	0.0223	0.0223
Schistosoma mansoni	opsin-like receptor	0.0006	0.0005	0.0005
Schistosoma mansoni	neuropeptide F-like receptor	0.0006	0.0005	0.0005
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.002	0.0224	1
Treponema pallidum	NADH oxidase	0.002	0.0224	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.0005	0.0005
Echinococcus granulosus	tyrosine kinase	0.0018	0.0193	0.0193
Brugia malayi	ORL1-like opioid receptor	0.0006	0.0005	0.0005
Echinococcus granulosus	g protein coupled receptor	0.0006	0.0005	0.0005
Schistosoma mansoni	neuropeptide f receptor 76f	0.0006	0.0005	0.0005
Echinococcus multilocularis	neuropeptide s receptor	0.0006	0.0005	0.0005
Echinococcus granulosus	biogenic amine 5HT receptor	0.0006	0.0005	0.0005
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.002	0.0224	0.0224
Schistosoma mansoni	neuropeptide receptor	0.0006	0.0005	0.0005
Echinococcus granulosus	G protein coupled receptor 139	0.0006	0.0005	0.0005
Onchocerca volvulus		0.0006	0.0005	0.0005
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.002	0.0224	0.0224
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0059	0.08	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0006	0.0005	0.0005
Loa Loa (eye worm)	G-protein coupled receptor	0.0006	0.0005	0.0005
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0006	0.0005	0.0005
Brugia malayi	putative neuropeptide receptor NPR1	0.0006	0.0005	0.0005
Echinococcus multilocularis	g-protein coupled receptor	0.0006	0.0005	0.0005

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 256 nM	Agonist activity at human CB2 receptor expressed in CHO-K1 cells assessed as forskolin-induced cAMP accumulation after 1 hr	ChEMBL.	24461289
EC50 (functional)	> 17000 nM	Agonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as forskolin-induced cAMP accumulation after 1 hr	ChEMBL.	24461289
Emax (functional)	= 49 %	Agonist activity at human CB2 receptor expressed in CHO-K1 cells assessed as forskolin-induced cAMP accumulation after 1 hr relative to control	ChEMBL.	24461289

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3114514

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1835066