Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.1998 | 0.3339 | 1 |
Mycobacterium tuberculosis | Possible haloalkane dehalogenase | 0.0095 | 0.0029 | 0.0029 |
Trichomonas vaginalis | lipase containing protein, putative | 0.1998 | 0.3339 | 1 |
Schistosoma mansoni | family S33 non-peptidase homologue (S33 family) | 0.0134 | 0.0097 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1998 | 0.3339 | 1 |
Leishmania major | hypothetical protein, conserved | 0.1998 | 0.3339 | 1 |
Toxoplasma gondii | alpha/beta hydrolase, putative | 0.0078 | 0 | 0.5 |
Toxoplasma gondii | homoserine O-acetyltransferase, putative | 0.0078 | 0 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.1998 | 0.3339 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0097 | 0.029 |
Echinococcus multilocularis | abhydrolase domain containing protein 11 | 0.0134 | 0.0097 | 0.029 |
Entamoeba histolytica | alpha/beta hydrolase domain protein, putative | 0.0078 | 0 | 0.5 |
Plasmodium falciparum | alpha/beta hydrolase, putative | 0.0134 | 0.0097 | 1 |
Mycobacterium leprae | Probable exported protease | 0.0078 | 0 | 0.5 |
Plasmodium vivax | alpha/beta hydrolase, putative | 0.0134 | 0.0097 | 1 |
Mycobacterium leprae | Probable homoserine o-acetyltransferase MetA | 0.0078 | 0 | 0.5 |
Mycobacterium leprae | Possible short-chain dehydrogenase EphD | 0.0078 | 0 | 0.5 |
Mycobacterium leprae | POSSIBLE SECRETED PROTEASE | 0.0078 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable haloalkane dehalogenase | 0.0095 | 0.0029 | 0.0029 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1998 | 0.3339 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.1998 | 0.3339 | 1 |
Echinococcus granulosus | abhydrolase domain containing protein 11 | 0.0134 | 0.0097 | 0.029 |
Entamoeba histolytica | alpha/beta hydrolase fold protein, putative | 0.0078 | 0 | 0.5 |
Onchocerca volvulus | 0.1998 | 0.3339 | 1 | |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0095 | 0.0029 | 0.0029 |
Brugia malayi | Lipase family protein | 0.1998 | 0.3339 | 1 |
Giardia lamblia | ENC6 protein | 0.0078 | 0 | 0.5 |
Mycobacterium tuberculosis | 4,9-DHSA hydrolase | 0.5749 | 0.9864 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0095 | 0.0029 | 0.0029 |
Trypanosoma brucei | lipase domain protein, putative | 0.1998 | 0.3339 | 1 |
Mycobacterium leprae | Probable exported protease | 0.0078 | 0 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.1998 | 0.3339 | 1 |
Loa Loa (eye worm) | lipase | 0.1998 | 0.3339 | 1 |
Mycobacterium leprae | POSSIBLE EPOXIDE HYDROLASE EPHE (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) | 0.0078 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0078 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.088 ug ml-1 | Inhibition of Herpes simplex virus-1 (HSV-1)-induced cytopathic effect in HUT78 cells. | ChEMBL. | 1354751 |
ED50 (functional) | = 0.088 ug ml-1 | Inhibition of Herpes simplex virus-1 (HSV-1)-induced cytopathic effect in HUT78 cells. | ChEMBL. | 1354751 |
ED50 (functional) | = 0.12 ug ml-1 | Inhibition of HIV-1-induced cytopathic effect in MT-4 cells. | ChEMBL. | 1354751 |
ED50 (functional) | = 0.12 ug ml-1 | Inhibition of HIV-1-induced cytopathic effect in MT-4 cells. | ChEMBL. | 1354751 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.