Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0067 | 0.123 | 0.123 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0056 | 0.097 | 1 |
Echinococcus multilocularis | jun protein | 0.0081 | 0.1573 | 0.1573 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0312 | 0.7185 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0312 | 0.7185 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0067 | 0.123 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0118 | 0.2482 | 0.2482 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0097 | 0.1967 | 0.1967 |
Brugia malayi | protein kinase C II. | 0.0097 | 0.1967 | 0.1967 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0069 | 0.1271 | 0.1271 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0118 | 0.2482 | 0.2482 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0038 | 0.0525 | 0.0525 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0069 | 0.1271 | 0.1271 |
Loa Loa (eye worm) | thymidylate synthase | 0.0118 | 0.2482 | 0.2482 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0038 | 0.0525 | 0.0525 |
Brugia malayi | hypothetical protein | 0.0064 | 0.1149 | 0.1149 |
Echinococcus granulosus | protein kinase C gamma type | 0.0057 | 0.0987 | 0.0987 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0312 | 0.7185 | 0.5 |
Brugia malayi | Protein kinase c protein 2 | 0.0053 | 0.0877 | 0.0877 |
Schistosoma mansoni | jun-related protein | 0.0066 | 0.1203 | 0.1203 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0312 | 0.7185 | 0.5 |
Echinococcus granulosus | jun protein | 0.0081 | 0.1573 | 0.1573 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0069 | 0.1271 | 0.1271 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1519 | 0.1519 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0083 | 0.1623 | 0.1623 |
Echinococcus multilocularis | thymidylate synthase | 0.0118 | 0.2482 | 0.2482 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0118 | 0.2482 | 0.1674 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0312 | 0.7185 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0525 | 0.0525 |
Echinococcus multilocularis | protein kinase c iota type | 0.0028 | 0.0284 | 0.0284 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0057 | 0.0987 | 0.0987 |
Echinococcus granulosus | protein kinase c iota type | 0.0028 | 0.0284 | 0.0284 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0097 | 0.1967 | 0.1967 |
Brugia malayi | thymidylate synthase | 0.0118 | 0.2482 | 0.2482 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0041 | 0.0593 | 0.0593 |
Schistosoma mansoni | atypical protein kinase C | 0.0028 | 0.0284 | 0.0284 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0081 | 0.1573 | 0.1573 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.1203 | 0.1203 |
Brugia malayi | bZIP transcription factor family protein | 0.0081 | 0.1573 | 0.1573 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0097 | 0.1967 | 0.1967 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0038 | 0.0525 | 0.0525 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0081 | 0.1573 | 0.1573 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0097 | 0.1967 | 0.1967 |
Brugia malayi | hypothetical protein | 0.0056 | 0.097 | 0.097 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0312 | 0.7185 | 1 |
Onchocerca volvulus | 0.0118 | 0.2482 | 1 | |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0069 | 0.1271 | 0.1271 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.081 | 0.081 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.