TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 549.611 | Formula: C31H35NO8
H donors: 2 H acceptors: 5 LogP: 5.65 Rotable bonds: 17
Rule of 5 violations (Lipinski): 2
SMILES: COc1ccc(cc1)CCCCCCCCOc1ccc([n+](c1/C=C/C(=O)O)[O-])COc1cccc(c1)C(=O)O
InChi: 1S/C31H35NO8/c1-38-26-15-12-23(13-16-26)9-6-4-2-3-5-7-20-39-29-18-14-25(32(37)28(29)17-19-30(33)34)22-40-27-11-8-10-24(21-27)31(35)36/h8,10-19,21H,2-7,9,20,22H2,1H3,(H,33,34)(H,35,36)/b19-17+
InChiKey: NJRBDYQJYBZHEH-HTXNQAPBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	leukotriene B4 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	adapter molecule crk	0.0324	0.436	0.3119
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0324	0.436	0.3119
Schistosoma mansoni	tensin-related	0.0324	0.436	0.3119
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0308	0.3946	0.2614
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0547	1	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0547	1	1
Echinococcus multilocularis	SH2 motif	0.0324	0.436	0.3119
Brugia malayi	Protein kinase domain containing protein	0.0547	1	1
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0324	0.436	0.3119
Onchocerca volvulus		0.0324	0.436	0.3119
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Schistosoma mansoni	shc transforming protein	0.0324	0.436	0.3119
Loa Loa (eye worm)	TK/FER protein kinase	0.0547	1	1
Echinococcus multilocularis	tensin	0.0324	0.436	0.3119
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0223	0.1804	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0547	1	1
Schistosoma mansoni	fatty-acid amide hydrolase	0.0308	0.3946	0.2614
Brugia malayi	SH2 domain containing protein	0.0324	0.436	0.3119
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0547	1	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0223	0.1804	0.5
Giardia lamblia	Kinase, NEK	0.0223	0.1804	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0547	1	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0223	0.1804	0.5
Schistosoma mansoni	tyrosine kinase	0.0547	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0324	0.436	0.3119
Schistosoma mansoni	suppressor of cytokine signaling	0.0324	0.436	0.3119
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Loa Loa (eye worm)	hypothetical protein	0.0324	0.436	0.3119
Brugia malayi	hypothetical protein	0.0547	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Echinococcus granulosus	tyrosine kinase	0.0547	1	1
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0308	0.3946	0.2614
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Onchocerca volvulus		0.0547	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0324	0.436	0.3119
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0547	1	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0547	1	1
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0324	0.436	0.3119
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0324	0.436	0.3119
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0324	0.436	0.3119
Loa Loa (eye worm)	TK/FER protein kinase	0.0547	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0223	0.1804	0.5
Echinococcus multilocularis	NCK adaptor protein	0.0324	0.436	0.3119
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0324	0.436	0.3119
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0547	1	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0223	0.1804	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0223	0.1804	0.5
Toxoplasma gondii	STE kinase	0.0223	0.1804	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0324	0.436	0.3119
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0324	0.436	0.3119
Loa Loa (eye worm)	SRC-1	0.0547	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0223	0.1804	0.5
Brugia malayi	Tensin	0.0324	0.436	0.3119
Trichomonas vaginalis	conserved hypothetical protein	0.0223	0.1804	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0547	1	1
Toxoplasma gondii	protein kinase	0.0223	0.1804	0.5
Trypanosoma brucei	protein kinase, putative	0.0223	0.1804	0.5
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0324	0.436	0.3119
Trypanosoma cruzi	protein kinase, putative	0.0223	0.1804	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0547	1	1
Loa Loa (eye worm)	hypothetical protein	0.0324	0.436	0.3119
Loa Loa (eye worm)	TK/FER protein kinase	0.0547	1	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0223	0.1804	0.5
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0308	0.3946	0.2614
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Loa Loa (eye worm)	hypothetical protein	0.0324	0.436	0.3119
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Schistosoma mansoni	vav2	0.0324	0.436	0.3119
Onchocerca volvulus		0.0547	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Leishmania major	protein kinase, putative	0.0223	0.1804	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0324	0.436	0.3119
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0547	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Echinococcus multilocularis	SH2 motif	0.0324	0.436	0.3119
Trypanosoma cruzi	protein kinase, putative	0.0223	0.1804	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Echinococcus multilocularis	tyrosine kinase	0.0547	1	1
Onchocerca volvulus		0.0324	0.436	0.3119
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0324	0.436	0.3119
Loa Loa (eye worm)	TK/FER protein kinase	0.0547	1	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0324	0.436	0.3119
Loa Loa (eye worm)	TK/FER protein kinase	0.0547	1	1
Brugia malayi	SH2 domain containing protein	0.0324	0.436	0.3119
Schistosoma mansoni	tensin-related	0.0324	0.436	0.3119
Echinococcus granulosus	c src tyrosine kinase	0.0547	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Loa Loa (eye worm)	hypothetical protein	0.0324	0.436	0.3119
Brugia malayi	Protein kinase domain containing protein	0.0547	1	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0547	1	1
Schistosoma mansoni	tensin	0.0324	0.436	0.3119
Brugia malayi	SH2 domain containing protein	0.0324	0.436	0.3119
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0223	0.1804	0.5
Giardia lamblia	Kinase	0.0223	0.1804	0.5
Schistosoma mansoni	hypothetical protein	0.0324	0.436	0.3119
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0324	0.436	0.3119
Loa Loa (eye worm)	TK/FER protein kinase	0.0547	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0324	0.436	0.3119
Toxoplasma gondii	protein kinase domain-containing protein	0.0223	0.1804	0.5
Echinococcus multilocularis	N chimaerin	0.0324	0.436	0.3119
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0547	1	1
Schistosoma mansoni	signal transduction protein lnk-related	0.0324	0.436	0.3119
Schistosoma mansoni	tensin	0.0324	0.436	0.3119
Brugia malayi	SH2 domain containing protein	0.0547	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Schistosoma mansoni	tyrosine kinase	0.0547	1	1
Echinococcus granulosus	expressed conserved protein	0.0324	0.436	0.3119
Echinococcus granulosus	growth factor receptor bound protein 2	0.0324	0.436	0.3119
Loa Loa (eye worm)	SH2 domain-containing protein	0.0324	0.436	0.3119
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0324	0.436	0.3119
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0547	1	1
Loa Loa (eye worm)	hypothetical protein	0.0324	0.436	0.3119
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0152	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0223	0.1804	0.5
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0324	0.436	0.3119
Loa Loa (eye worm)	hypothetical protein	0.0324	0.436	0.3119
Schistosoma mansoni	growth factor receptor-bound protein	0.0324	0.436	0.3119
Trichomonas vaginalis	conserved hypothetical protein	0.0223	0.1804	0.5
Echinococcus granulosus	NCK adaptor protein	0.0324	0.436	0.3119
Schistosoma mansoni	SH2A	0.0324	0.436	0.3119
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0547	1	1
Loa Loa (eye worm)	hypothetical protein	0.0547	1	1
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0324	0.436	0.3119
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0223	0.1804	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0547	1	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0547	1	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0223	0.1804	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0324	0.436	0.3119
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0324	0.436	0.3119
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0547	1	1
Echinococcus granulosus	SHC transforming protein 3	0.0324	0.436	0.3119
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0324	0.436	0.3119
Brugia malayi	Tyrosine-protein kinase abl-1	0.0547	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Trichomonas vaginalis	TK family protein kinase	0.0223	0.1804	0.5
Loa Loa (eye worm)	hypothetical protein	0.0324	0.436	0.3119
Brugia malayi	Variant SH3 domain containing protein	0.0326	0.4418	0.319
Brugia malayi	protein-tyrosine kinase	0.0547	1	1
Loa Loa (eye worm)	hypothetical protein	0.0324	0.436	0.3119
Schistosoma mansoni	nck2/grb4	0.0324	0.436	0.3119
Echinococcus granulosus	tensin	0.0324	0.436	0.3119
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0223	0.1804	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0324	0.436	0.3119
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0324	0.436	0.3119
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Echinococcus multilocularis	tensin	0.0324	0.436	0.3119
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0547	1	1
Giardia lamblia	Kinase, NEK	0.0223	0.1804	0.5
Echinococcus multilocularis	signal transduction protein lnk realted	0.0324	0.436	0.3119
Schistosoma mansoni	hypothetical protein	0.0324	0.436	0.3119
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0324	0.436	0.3119
Schistosoma mansoni	tyrosine kinase	0.0547	1	1
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0324	0.436	0.3119
Brugia malayi	Variant SH3 domain containing protein	0.0324	0.436	0.3119
Echinococcus granulosus	tyrosine protein kinase shark	0.0547	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0324	0.436	0.3119
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0547	1	1
Leishmania major	hypothetical protein, conserved	0.0223	0.1804	0.5
Loa Loa (eye worm)	TK protein kinase	0.0547	1	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0547	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0324	0.436	0.3119
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0547	1	1
Giardia lamblia	Protein 21.1	0.0223	0.1804	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.0547	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Loa Loa (eye worm)	hypothetical protein	0.0324	0.436	0.3119
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0547	1	1
Schistosoma mansoni	amidase	0.0308	0.3946	0.2614
Echinococcus granulosus	SH2 motif	0.0324	0.436	0.3119
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0547	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0223	0.1804	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Brugia malayi	SH2 domain containing protein	0.0324	0.436	0.3119
Plasmodium falciparum	protein kinase, putative	0.0223	0.1804	0.5
Onchocerca volvulus		0.0547	1	1
Brugia malayi	amidase	0.0308	0.3946	0.2614
Loa Loa (eye worm)	hypothetical protein	0.0324	0.436	0.3119
Echinococcus multilocularis	SH2 domain containing protein 7	0.0324	0.436	0.3119
Schistosoma mansoni	GTPase activating protein	0.0324	0.436	0.3119
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0324	0.436	0.3119
Brugia malayi	Protein kinase domain containing protein	0.0547	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0223	0.1804	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0547	1	1
Plasmodium falciparum	protein kinase, putative	0.0223	0.1804	0.5
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0324	0.436	0.3119
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0223	0.1804	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0324	0.436	0.3119
Mycobacterium ulcerans	carboxylesterase, LipT	0.0152	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Loa Loa (eye worm)	hypothetical protein	0.0308	0.3946	0.2614
Echinococcus multilocularis	SHC transforming protein 3	0.0324	0.436	0.3119
Trichomonas vaginalis	protein kinase atn1, putative	0.0223	0.1804	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0223	0.1804	0.5
Brugia malayi	Sex muscle abnormal protein 5	0.0324	0.436	0.3119
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Brugia malayi	SRC-1	0.0547	1	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0324	0.436	0.3119
Echinococcus multilocularis	SH2 motif	0.0324	0.436	0.3119
Loa Loa (eye worm)	TK/FER protein kinase	0.0547	1	1
Loa Loa (eye worm)	hypothetical protein	0.0324	0.436	0.3119
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0324	0.436	0.3119
Echinococcus granulosus	signal transduction protein lnk realted	0.0324	0.436	0.3119
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Echinococcus granulosus	tyrosine kinase	0.0547	1	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0326	0.4418	0.319
Onchocerca volvulus		0.0547	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0223	0.1804	0.5
Echinococcus granulosus	SH2 domain containing protein 7	0.0324	0.436	0.3119
Leishmania major	protein kinase, putative	0.0223	0.1804	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0324	0.436	0.3119
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Trichomonas vaginalis	STE family protein kinase	0.0223	0.1804	0.5
Loa Loa (eye worm)	hypothetical protein	0.0324	0.436	0.3119
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0324	0.436	0.3119
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0308	0.3946	0.2614
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0324	0.436	0.3119
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0547	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0324	0.436	0.3119
Brugia malayi	RhoGAP domain containing protein	0.0324	0.436	0.3119
Onchocerca volvulus		0.0324	0.436	0.3119
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0547	1	1
Echinococcus granulosus	N chimaerin	0.0324	0.436	0.3119
Entamoeba histolytica	protein kinase, putative	0.0324	0.436	0.3119
Plasmodium falciparum	protein kinase, putative	0.0223	0.1804	0.5
Loa Loa (eye worm)	STAT protein	0.0324	0.436	0.3119
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0547	1	1
Schistosoma mansoni	tyrosine kinase	0.0547	1	1
Echinococcus multilocularis		0.0324	0.436	0.3119
Onchocerca volvulus		0.0324	0.436	0.3119
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0223	0.1804	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0547	1	1
Onchocerca volvulus		0.0324	0.436	0.3119
Trichomonas vaginalis	conserved hypothetical protein	0.0223	0.1804	0.5
Trypanosoma brucei	Pseudokinase, putative	0.0223	0.1804	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0547	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0223	0.1804	0.5
Schistosoma mansoni	tyrosine kinase	0.0547	1	1
Echinococcus granulosus	hypothetical protein	0.0324	0.436	0.3119
Brugia malayi	Protein kinase domain containing protein	0.0547	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Onchocerca volvulus		0.0324	0.436	0.3119
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0324	0.436	0.3119
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0223	0.1804	0.5
Echinococcus multilocularis	c src tyrosine kinase	0.0547	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0547	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0223	0.1804	0.5
Plasmodium vivax	protein kinase, putative	0.0223	0.1804	0.5
Entamoeba histolytica	SH2 domain containing protein	0.0324	0.436	0.3119
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0547	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0547	1	1
Loa Loa (eye worm)	hypothetical protein	0.0324	0.436	0.3119
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Onchocerca volvulus		0.0547	1	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0324	0.436	0.3119
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0223	0.1804	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0324	0.436	0.3119
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Loa Loa (eye worm)	hypothetical protein	0.0324	0.436	0.3119
Loa Loa (eye worm)	hypothetical protein	0.0324	0.436	0.3119
Schistosoma mansoni	tensin	0.0324	0.436	0.3119
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0547	1	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0324	0.436	0.3119
Brugia malayi	SH2 domain containing protein	0.0547	1	1
Schistosoma mansoni	tyrosine kinase	0.0547	1	1
Echinococcus granulosus	SH2 motif	0.0324	0.436	0.3119
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0547	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Brugia malayi	SH2 domain containing protein	0.0324	0.436	0.3119
Brugia malayi	hypothetical protein	0.0324	0.436	0.3119
Brugia malayi	SH2 domain containing protein	0.0324	0.436	0.3119
Onchocerca volvulus		0.0547	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0324	0.436	0.3119
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.1804	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0547	1	1
Brugia malayi	SH2 domain containing protein	0.0324	0.436	0.3119

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.89 uM	Antagonistic activity to inhibit the calcium mobilization response in human U-937 cells	ChEMBL.	8230122
IC50 (functional)	= 0.89 uM	Antagonistic activity to inhibit the calcium mobilization response in human U-937 cells	ChEMBL.	8230122
Ki (binding)	= 0.15 uM	Binding affinity of [3H]-LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL.	8230122
Ki (binding)	= 0.15 uM	Binding affinity of [3H]-LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL.	8230122

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	8230122

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL110797

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 183688