TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 264.28 | Formula: C12H16N4O3
H donors: 4 H acceptors: 3 LogP: 0.29 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)CCCCCc1[nH]c2c(c1)c(=O)[nH]c(n2)N
InChi: 1S/C12H16N4O3/c13-12-15-10-8(11(19)16-12)6-7(14-10)4-2-1-3-5-9(17)18/h6H,1-5H2,(H,17,18)(H4,13,14,15,16,19)
InChiKey: ODBULEALJNSQJV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	protein kinase	0.0256	0.58	0.4151
Brugia malayi	Protein kinase domain containing protein	0.0172	0.2893	0.3536
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Giardia lamblia	Kinase, NEK	0.0172	0.2893	0.5
Brugia malayi	Furin-like cysteine rich region family protein	0.0172	0.2893	0.3536
Entamoeba histolytica	protein kinase, putative	0.0172	0.2893	0.4987
Schistosoma mansoni	tyrosine kinase	0.0178	0.3095	0.0288
Brugia malayi	Protein kinase domain containing protein	0.0172	0.2893	0.3536
Echinococcus granulosus	tyrosine protein kinase shark	0.0175	0.2995	0.0144
Brugia malayi	Protein kinase domain containing protein	0.0175	0.2995	0.3765
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0262	0.6002	0.4375
Entamoeba histolytica	tyrosine kinase, putative	0.0172	0.2893	0.4987
Loa Loa (eye worm)	TK/FER protein kinase	0.0175	0.2995	0.0144
Schistosoma mansoni	tyrosine kinase	0.0376	0.9898	1
Onchocerca volvulus		0.0175	0.2995	1
Entamoeba histolytica	protein kinase domain containing protein	0.0172	0.2893	0.4987
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0172	0.2893	0.3536
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Trichomonas vaginalis	STE family protein kinase	0.0172	0.2893	0.5
Brugia malayi	hypothetical protein	0.0172	0.2893	0.3536
Entamoeba histolytica	tyrosine kinase, putative	0.0172	0.2893	0.4987
Entamoeba histolytica	protein kinase, putative	0.0172	0.2893	0.4987
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0172	0.2893	0.4987
Entamoeba histolytica	serine/threonine kinase, putative	0.0172	0.2893	0.4987
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Trichomonas vaginalis	TK family protein kinase	0.0172	0.2893	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0172	0.2893	0.4987
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0172	0.2893	0.3536
Entamoeba histolytica	protein kinase domain containing protein	0.0172	0.2893	0.4987
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0172	0.2893	0.4987
Entamoeba histolytica	hypothetical protein, conserved	0.0172	0.2893	0.4987
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Entamoeba histolytica	protein kinase, putative	0.0172	0.2893	0.4987
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Echinococcus granulosus	c src tyrosine kinase	0.0178	0.3095	0.0284
Entamoeba histolytica	receptor protein kinase, putative	0.0172	0.2893	0.4987
Brugia malayi	Protein kinase domain containing protein	0.0172	0.2893	0.3536
Trichomonas vaginalis	conserved hypothetical protein	0.0172	0.2893	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0175	0.2995	0.0144
Leishmania major	protein kinase, putative	0.0256	0.58	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0178	0.3095	0.0284
Echinococcus granulosus	tyrosine kinase	0.0175	0.2995	0.0144
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0172	0.2893	0.4987
Entamoeba histolytica	tyrosin kinase, putative	0.0172	0.2893	0.4987
Entamoeba histolytica	serine/threonine kinase, putative	0.0172	0.2893	0.4987
Entamoeba histolytica	hypothetical protein	0.0172	0.2893	0.4987
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0172	0.2893	0.3536
Loa Loa (eye worm)	TK/FER protein kinase	0.0175	0.2995	0.0144
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0172	0.2893	0.3536
Entamoeba histolytica	protein kinase domain containing protein	0.0172	0.2893	0.4987
Brugia malayi	hypothetical protein	0.0175	0.2995	0.3765
Brugia malayi	Protein kinase domain containing protein	0.0172	0.2893	0.3536
Schistosoma mansoni	tyrosine kinase	0.0178	0.3095	0.0288
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Entamoeba histolytica	protein kinase, putative	0.0172	0.2893	0.4987
Entamoeba histolytica	serine/threonine kinase, putative	0.0172	0.2893	0.4987
Entamoeba histolytica	tyrosine kinase, putative	0.0172	0.2893	0.4987
Entamoeba histolytica	hypothetical protein	0.0172	0.2893	0.4987
Brugia malayi	ephrin receptor 1 precursor	0.0172	0.2893	0.3536
Loa Loa (eye worm)	TK/FER protein kinase	0.0175	0.2995	0.0144
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0172	0.2893	0.4987
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0178	0.3095	0.0284
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0172	0.2893	0.4987
Schistosoma mansoni	tyrosine kinase	0.0175	0.2995	0.0146
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0178	0.3095	0.0284
Echinococcus multilocularis	tyrosine protein kinase shark	0.0175	0.2995	0.0144
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0178	0.3095	0.0284
Onchocerca volvulus		0.0175	0.2995	1
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0172	0.2893	0.4987
Entamoeba histolytica	protein kinase, putative	0.0172	0.2893	0.4987
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0175	0.2995	0.0144
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0175	0.2992	0.0142
Brugia malayi	Guanylyl cyclase protein 23	0.0172	0.2893	0.3536
Brugia malayi	Protein kinase domain containing protein	0.0175	0.2995	0.3765
Onchocerca volvulus		0.0175	0.2995	1
Brugia malayi	Protein kinase domain containing protein	0.0172	0.2893	0.3536
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0172	0.2893	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0256	0.58	1
Entamoeba histolytica	hypothetical protein	0.0172	0.2893	0.4987
Entamoeba histolytica	tyrosine kinase, putative	0.0172	0.2893	0.4987
Brugia malayi	Protein kinase domain containing protein	0.0175	0.2995	0.3765
Brugia malayi	Protein kinase domain containing protein	0.0172	0.2893	0.3536
Brugia malayi	Protein kinase domain containing protein	0.0172	0.2893	0.3536
Trichomonas vaginalis	CAMK family protein kinase	0.0172	0.2893	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0175	0.2995	0.0144
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Entamoeba histolytica	protein kinase, putative	0.0172	0.2893	0.4987
Echinococcus multilocularis	activin receptor type	0.0256	0.58	0.4091
Entamoeba histolytica	tyrosine kinase, putative	0.0172	0.2893	0.4987
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0172	0.2893	0.4987
Echinococcus granulosus	tyrosine protein kinase Blk	0.0175	0.2995	0.0144
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Entamoeba histolytica	protein kinase, putative	0.0172	0.2893	0.4987
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Loa Loa (eye worm)	SRC-1	0.0178	0.3095	0.0284
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0172	0.2893	0.3536
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0256	0.58	0.4091
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0172	0.2893	0.5
Brugia malayi	Protein kinase domain containing protein	0.0175	0.2995	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0178	0.3095	0.0284
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Brugia malayi	Protein kinase domain containing protein	0.0172	0.2893	0.3536
Brugia malayi	SH2 domain containing protein	0.0175	0.2995	0.3765
Entamoeba histolytica	tyrosine kinase, putative	0.0172	0.2893	0.4987
Giardia lamblia	Kinase, NEK	0.0172	0.2893	0.5
Brugia malayi	Protein kinase domain containing protein	0.0172	0.2893	0.3536
Trichomonas vaginalis	conserved hypothetical protein	0.0172	0.2893	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0172	0.2893	0.5
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0172	0.2893	0.3536
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Plasmodium falciparum	protein kinase, putative	0.0256	0.58	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0172	0.2893	0.3536
Brugia malayi	Protein kinase domain containing protein	0.0172	0.2893	0.3536
Echinococcus granulosus	tyrosine protein kinase Srms	0.0175	0.2995	0.0144
Entamoeba histolytica	tyrosine kinase, putative	0.0172	0.2893	0.4987
Entamoeba histolytica	receptor protein kinase, putative	0.0172	0.2893	0.4987
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Echinococcus granulosus	activin receptor type	0.0256	0.58	0.4091
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Entamoeba histolytica	ankyrin repeat protein	0.0172	0.2893	0.4987
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0172	0.2893	0.4987
Onchocerca volvulus		0.0175	0.2995	1
Giardia lamblia	Protein 21.1	0.0172	0.2893	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0256	0.58	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0172	0.2893	0.5
Brugia malayi	Protein kinase domain containing protein	0.0172	0.2893	0.3536
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0172	0.2893	0.4987
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0172	0.2893	0.4987
Entamoeba histolytica	protein kinase, putative	0.0172	0.2893	0.4987
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Brugia malayi	Protein kinase domain containing protein	0.0172	0.2893	0.3536
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Onchocerca volvulus		0.0175	0.2995	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0175	0.2995	0.0144
Loa Loa (eye worm)	TK/FER protein kinase	0.0175	0.2995	0.0144
Entamoeba histolytica	protein kinase domain containing protein	0.0172	0.2893	0.4987
Brugia malayi	Tyrosine-protein kinase abl-1	0.0256	0.5773	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0172	0.2893	0.4987
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0178	0.3095	0.0284
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0178	0.3095	0.0284
Entamoeba histolytica	protein kinase domain containing protein	0.0172	0.2893	0.4987
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0178	0.3095	0.0288
Brugia malayi	SH2 domain containing protein	0.0175	0.2995	0.3765
Entamoeba histolytica	hypothetical protein	0.0172	0.2893	0.4987
Loa Loa (eye worm)	TK/FER protein kinase	0.0175	0.2995	0.0144
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0256	0.58	1
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Schistosoma mansoni	tyrosine kinase	0.0175	0.2995	0.0146
Brugia malayi	Protein kinase domain containing protein	0.0172	0.2893	0.3536
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Entamoeba histolytica	ankyrin repeat protein	0.0172	0.2893	0.4987
Brugia malayi	Protein kinase domain containing protein	0.0175	0.2995	0.3765
Entamoeba histolytica	protein kinase domain containing protein	0.0172	0.2893	0.4987
Entamoeba histolytica	protein kinase domain containing protein	0.0172	0.2893	0.4987
Trichomonas vaginalis	conserved hypothetical protein	0.0172	0.2893	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Brugia malayi	hypothetical protein	0.0172	0.2893	0.3536
Entamoeba histolytica	hypothetical protein	0.0172	0.2893	0.4987
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Entamoeba histolytica	hypothetical protein	0.0172	0.2893	0.4987
Brugia malayi	Protein kinase domain containing protein	0.0172	0.2893	0.3536
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0175	0.2995	0.0144
Brugia malayi	C-terminal src kinase protein 1	0.0172	0.2893	0.3536
Entamoeba histolytica	protein kinase domain containing protein	0.0172	0.2893	0.4987
Entamoeba histolytica	tyrosine kinase, putative	0.0172	0.2893	0.4987
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0172	0.2893	0.4987
Trichomonas vaginalis	conserved hypothetical protein	0.0172	0.2893	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0175	0.2995	0.0144
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0175	0.2995	0.0144
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0172	0.2893	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0178	0.3095	0.0284
Entamoeba histolytica	serine/threonine kinase, putative	0.0172	0.2893	0.4987
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Entamoeba histolytica	protein kinase, putative	0.0172	0.2893	0.4987
Entamoeba histolytica	cysteine surface protein, putative	0.0172	0.2893	0.4987
Trichomonas vaginalis	conserved hypothetical protein	0.0172	0.2893	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0172	0.2893	0.4987
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0178	0.3095	0.0284
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Loa Loa (eye worm)	TK protein kinase	0.0175	0.2995	0.0144
Brugia malayi	Receptor family ligand binding region containing protein	0.0172	0.2893	0.3536
Entamoeba histolytica	hypothetical protein	0.0172	0.2893	0.4987
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0172	0.2893	0.4987
Echinococcus multilocularis	c src tyrosine kinase	0.0178	0.3095	0.0284
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Entamoeba histolytica	protein kinase, putative	0.0172	0.2893	0.4987
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0172	0.2893	0.4987
Brugia malayi	Raf kinase	0.0172	0.2893	0.3536
Entamoeba histolytica	tyrosine kinase, putative	0.0172	0.2893	0.4987
Entamoeba histolytica	protein kinase, putative	0.0172	0.2893	0.4987
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0256	0.58	1
Entamoeba histolytica	hypothetical protein	0.0172	0.2893	0.4987
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Loa Loa (eye worm)	hypothetical protein	0.025	0.5571	0.3769
Entamoeba histolytica	protein kinase, putative	0.0172	0.2893	0.4987
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0178	0.3095	0.0284
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0178	0.3095	0.0284
Entamoeba histolytica	protein kinase, putative	0.0172	0.2893	0.4987
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0178	0.3095	0.0284
Trichomonas vaginalis	conserved hypothetical protein	0.0172	0.2893	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0256	0.58	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0172	0.2893	0.4987
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0256	0.5773	0.4053
Brugia malayi	Protein kinase domain containing protein	0.0172	0.2893	0.3536
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0172	0.2893	0.4987
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0172	0.2893	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0172	0.2893	0.3536
Entamoeba histolytica	serine/threonine kinase, putative	0.0172	0.2893	0.4987
Schistosoma mansoni	protein kinase	0.0256	0.58	0.4151
Onchocerca volvulus		0.0175	0.2995	1
Entamoeba histolytica	hypothetical protein	0.0172	0.2893	0.4987
Entamoeba histolytica	tyrosine kinase, putative	0.0172	0.2893	0.4987
Entamoeba histolytica	protein kinase domain containing protein	0.0172	0.2893	0.4987
Echinococcus granulosus	tyrosine kinase	0.0175	0.2995	0.0144
Entamoeba histolytica	serine/threonine kinase, putative	0.0172	0.2893	0.4987
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Brugia malayi	Protein kinase domain containing protein	0.0172	0.2893	0.3536
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0175	0.2995	0.0144
Schistosoma mansoni	tyrosine kinase	0.0178	0.3095	0.0288
Entamoeba histolytica	protein kinase, putative	0.0172	0.2893	0.4987
Loa Loa (eye worm)	TK/FER protein kinase	0.0175	0.2995	0.0144
Entamoeba histolytica	tyrosin kinase, putative	0.0172	0.2893	0.4987
Brugia malayi	Protein kinase domain containing protein	0.0172	0.2893	0.3536
Entamoeba histolytica	protein kinase domain containing protein	0.0172	0.2893	0.4987
Brugia malayi	Protein kinase domain containing protein	0.0172	0.2893	0.3536
Brugia malayi	SRC-1	0.0178	0.3095	0.3989
Schistosoma mansoni	tyrosine kinase	0.0178	0.3095	0.0288
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0172	0.2893	0.4987
Brugia malayi	Protein kinase domain containing protein	0.0172	0.2893	0.3536
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0172	0.2893	0.4987
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0172	0.2893	0.4987
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Brugia malayi	Protein kinase domain containing protein	0.0172	0.2893	0.3536
Brugia malayi	Protein kinase domain containing protein	0.0172	0.2893	0.3536
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0172	0.2893	0.4987
Entamoeba histolytica	protein kinase domain containing protein	0.0172	0.2893	0.4987
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0178	0.3095	0.0284
Entamoeba histolytica	protein kinase, putative	0.0172	0.2893	0.4987
Entamoeba histolytica	protein kinase, putative	0.0172	0.2893	0.4987
Brugia malayi	Tyrosine-protein kinase PR2	0.0172	0.2893	0.3536
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0178	0.3095	0.0284
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Entamoeba histolytica	hypothetical protein	0.0172	0.2893	0.4987
Entamoeba histolytica	tyrosine kinase, putative	0.0172	0.2893	0.4987
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Brugia malayi	protein-tyrosine kinase	0.0175	0.2995	0.3765
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0172	0.2893	0.5
Brugia malayi	Protein kinase domain containing protein	0.0172	0.2893	0.3536
Brugia malayi	Protein kinase domain containing protein	0.0172	0.2893	0.3536
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0172	0.2893	0.3536
Entamoeba histolytica	protein kinase domain containing protein	0.0172	0.2893	0.4987
Entamoeba histolytica	tyrosine kinase, putative	0.0172	0.2893	0.4987
Plasmodium vivax	protein kinase, putative	0.0172	0.2893	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0172	0.2893	0.4987
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0178	0.3095	0.0284
Brugia malayi	Protein kinase domain containing protein	0.0172	0.2893	0.3536
Entamoeba histolytica	hypothetical protein	0.0172	0.2893	0.4987
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Schistosoma mansoni	protein kinase	0.0256	0.58	0.4151
Entamoeba histolytica	tyrosine kinase, putative	0.0172	0.2893	0.4987
Trichomonas vaginalis	AGC family protein kinase	0.0172	0.2893	0.5
Entamoeba histolytica	protein kinase, putative	0.0172	0.2893	0.4987
Entamoeba histolytica	tyrosin kinase, putative	0.0172	0.2893	0.4987
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0178	0.3095	0.0284
Entamoeba histolytica	protein kinase domain containing protein	0.0172	0.2893	0.4987
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0175	0.2995	0.5163
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0178	0.3095	0.0284
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0178	0.3095	0.0284
Brugia malayi	integrin-linked kinase	0.0172	0.2893	0.3536
Entamoeba histolytica	protein kinase domain containing protein	0.0172	0.2893	0.4987
Entamoeba histolytica	tyrosine kinase, putative	0.0172	0.2893	0.4987
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0256	0.58	0.4091
Loa Loa (eye worm)	hypothetical protein	0.0175	0.2995	0.0144
Entamoeba histolytica	tyrosine kinase, putative	0.0172	0.2893	0.4987
Echinococcus multilocularis	tyrosine kinase	0.0175	0.2995	0.0144
Loa Loa (eye worm)	TK/FER protein kinase	0.0175	0.2995	0.0144
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0172	0.2893	0.5
Entamoeba histolytica	protein kinase, putative	0.0172	0.2893	0.4987
Trichomonas vaginalis	conserved hypothetical protein	0.0172	0.2893	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0172	0.2893	0.4987
Entamoeba histolytica	protein kinase domain containing protein	0.0172	0.2893	0.4987
Entamoeba histolytica	protein kinase domain containing protein	0.0172	0.2893	0.4987
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Brugia malayi	Protein kinase domain containing protein	0.0172	0.2893	0.3536
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0175	0.2995	0.0144
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5
Trypanosoma brucei	protein kinase, putative	0.0256	0.58	1
Giardia lamblia	Kinase	0.0172	0.2893	0.5
Entamoeba histolytica	protein kinase, putative	0.0172	0.2893	0.4987
Trichomonas vaginalis	TKL family protein kinase	0.0172	0.2893	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 1000 nM	Growth inhibition of human KB cells expressing human RFC/FRalpha/PCFT after 96 hrs by CellTiter-blue assay in presence of folic acid	ChEMBL.	24111942

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	24111942

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3086869

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1838912