TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 358.35 | Formula: C15H11FN6O2S
H donors: 1 H acceptors: 6 LogP: 1.72 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccn2c(n1)nc(n2)S(=O)(=O)Nc1c(F)ccc2c1nccc2
InChi: 1S/C15H11FN6O2S/c1-9-6-8-22-14(18-9)19-15(20-22)25(23,24)21-13-11(16)5-4-10-3-2-7-17-12(10)13/h2-8,21H,1H3
InChiKey: CWHXOBLQMBKMHY-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Nicotiana tabacum	Acetolactate synthase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	Acetolactate synthase	Get druggable targets OG5_126899	All targets in OG5_126899
Mycobacterium ulcerans	putative oxalyl-CoA decarboxylase	Get druggable targets OG5_126899	All targets in OG5_126899
Mycobacterium tuberculosis	Probable oxalyl-CoA decarboxylase OxcA	Get druggable targets OG5_126899	All targets in OG5_126899
Mycobacterium tuberculosis	Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS)	Get druggable targets OG5_126899	All targets in OG5_126899
Loa Loa (eye worm)	thiamine pyrophosphate enzyme	Get druggable targets OG5_126899	All targets in OG5_126899
Schistosoma japonicum	ko:K01651 acetolactate synthase [EC2.2.1.6], putative	Get druggable targets OG5_126899	All targets in OG5_126899
Loa Loa (eye worm)	ILVBL protein	Get druggable targets OG5_126899	All targets in OG5_126899
Schistosoma mansoni	acetolactate synthase	Get druggable targets OG5_126899	All targets in OG5_126899
Mycobacterium leprae	PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE)	Get druggable targets OG5_126899	All targets in OG5_126899
Schistosoma japonicum	ko:K01651 acetolactate synthase [EC2.2.1.6], putative	Get druggable targets OG5_126899	All targets in OG5_126899
Mycobacterium tuberculosis	Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase)	Get druggable targets OG5_126899	All targets in OG5_126899
Schistosoma mansoni	acetolactate synthase	Get druggable targets OG5_126899	All targets in OG5_126899
Mycobacterium leprae	Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS)	Get druggable targets OG5_126899	All targets in OG5_126899
Mycobacterium ulcerans	acetolactate synthase 1 catalytic subunit	Get druggable targets OG5_126899	All targets in OG5_126899
Candida albicans	Acetolactate synthase	Get druggable targets OG5_126899	All targets in OG5_126899
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_126899	All targets in OG5_126899
Brugia malayi	Thiamine pyrophosphate enzyme, central domain containing protein	Get druggable targets OG5_126899	All targets in OG5_126899

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0067	0.1321	0.5
Mycobacterium tuberculosis	Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS)	0.0133	1	1
Onchocerca volvulus		0.0067	0.1321	0.5
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0067	0.1321	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.0067	0.1321	0.5
Echinococcus granulosus	raf serine:threonine protein kinase	0.0067	0.1321	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0067	0.1321	0.5
Echinococcus granulosus	insulin receptor	0.0067	0.1321	0.5
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0067	0.1321	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5
Toxoplasma gondii	protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0067	0.1321	0.5
Plasmodium vivax	acyl-CoA synthetase, putative	0.0076	0.2525	1
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0067	0.1321	0.5
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Schistosoma mansoni	acetolactate synthase	0.0114	0.7458	1
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Mycobacterium ulcerans	putative oxalyl-CoA decarboxylase	0.0133	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0067	0.1321	0.5
Mycobacterium tuberculosis	Probable oxalyl-CoA decarboxylase OxcA	0.0133	1	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Giardia lamblia	Kinase, NEK	0.0067	0.1321	0.5
Echinococcus granulosus	protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine kinase	0.0067	0.1321	0.5
Mycobacterium leprae	PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE)	0.0133	1	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	insulin receptor	0.0067	0.1321	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.1321	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0067	0.1321	0.5
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0067	0.1321	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0067	0.1321	0.5
Leishmania major	putative pyruvate/indole-pyruvate carboxylase, putative	0.0076	0.2525	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0067	0.1321	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.1321	0.5
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0067	0.1321	0.5
Trichomonas vaginalis	STE family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0067	0.1321	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0067	0.1321	0.5
Plasmodium falciparum	acyl-CoA synthetase	0.0076	0.2525	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0067	0.1321	0.5
Giardia lamblia	Protein 21.1	0.0067	0.1321	0.5
Echinococcus granulosus	integrin linked protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase shark	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0067	0.1321	0.5
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0067	0.1321	0.5
Schistosoma mansoni	acetolactate synthase	0.0114	0.7458	1
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0067	0.1321	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Mycobacterium ulcerans	acetolactate synthase 1 catalytic subunit	0.0133	1	1
Echinococcus multilocularis	protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	receptor type guanylyl cyclase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0067	0.1321	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.1321	0.5
Mycobacterium leprae	Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS)	0.0133	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0067	0.1321	0.5
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	c src tyrosine kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Giardia lamblia	Kinase, NEK	0.0067	0.1321	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0067	0.1321	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0067	0.1321	0.5
Echinococcus multilocularis	transfer RNA-Thr	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0067	0.1321	0.5
Echinococcus multilocularis	protein tyrosine kinase	0.0067	0.1321	0.5
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0067	0.1321	0.5
Trypanosoma brucei	Pseudokinase, putative	0.0067	0.1321	0.5
Echinococcus granulosus	ephrin type A receptor 4 A	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0067	0.1321	0.5
Entamoeba histolytica	hypothetical protein	0.0074	0.2324	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0067	0.1321	0.5
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0067	0.1321	0.5
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trypanosoma cruzi	protein kinase, putative	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0067	0.1321	0.5
Echinococcus multilocularis	protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0067	0.1321	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0067	0.1321	0.5
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0067	0.1321	0.5
Trypanosoma brucei	protein kinase, putative	0.0067	0.1321	0.5
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0067	0.1321	0.5
Mycobacterium ulcerans	hypothetical protein	0.0133	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0074	0.2324	1
Echinococcus granulosus	epidermal growth factor receptor	0.0067	0.1321	0.5
Loa Loa (eye worm)	ILVBL protein	0.008	0.3106	1
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5
Echinococcus multilocularis	FL cytokine receptor	0.0067	0.1321	0.5
Echinococcus granulosus	c src tyrosine kinase	0.0067	0.1321	0.5
Echinococcus granulosus	protein tyrosine kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Loa Loa (eye worm)	thiamine pyrophosphate enzyme	0.0076	0.2542	0.684
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	natriuretic peptide receptor 1	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0067	0.1321	0.5
Toxoplasma gondii	STE kinase	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase HCK	0.0067	0.1321	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0067	0.1321	0.5
Onchocerca volvulus	Tyrosine kinase homolog	0.0067	0.1321	0.5
Echinococcus granulosus	activin receptor type	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase pr2	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	activated cdc42 kinase 1	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0067	0.1321	0.5
Echinococcus multilocularis	activin receptor type	0.0067	0.1321	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0067	0.1321	0.5
Echinococcus granulosus	kinase suppressor of Ras 1	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5
Giardia lamblia	Kinase	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0067	0.1321	0.5
Echinococcus multilocularis	integrin linked protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TK family protein kinase	0.0067	0.1321	0.5
Entamoeba histolytica	hypothetical protein	0.0074	0.2324	1
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Entamoeba histolytica	hypothetical protein	0.0074	0.2324	1
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trypanosoma cruzi	protein kinase, putative	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Entamoeba histolytica	protein kinase, putative	0.0074	0.2324	1
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	heat shock protein 70	0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0067	0.1321	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.1321	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 17.1 nM	Inhibition of wild type Nicotiana tabacum (tobacco) GST-tagged acetolactate synthase expressed in Escherichia coli by modified Westerfeld method	ChEMBL.	10329466
IC50 (binding)	= 16.5 uM	Inhibition of wild type Nicotiana tabacum (tobacco) S4-Hra GST-tagged acetolactate synthase mutant expressed in Escherichia coli by modified Westerfeld method	ChEMBL.	10329466

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2269029

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1841730