TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 358.35 | Formula: C15H11FN6O2S
H donors: 1 H acceptors: 6 LogP: 1.72 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccn2c(n1)nc(n2)S(=O)(=O)Nc1c(F)ccc2c1nccc2
InChi: 1S/C15H11FN6O2S/c1-9-6-8-22-14(18-9)19-15(20-22)25(23,24)21-13-11(16)5-4-10-3-2-7-17-12(10)13/h2-8,21H,1H3
InChiKey: CWHXOBLQMBKMHY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Nicotiana tabacum	Acetolactate synthase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium ulcerans	acetolactate synthase 1 catalytic subunit	Get druggable targets OG5_126899	All targets in OG5_126899
Mycobacterium tuberculosis	Probable oxalyl-CoA decarboxylase OxcA	Get druggable targets OG5_126899	All targets in OG5_126899
Mycobacterium tuberculosis	Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS)	Get druggable targets OG5_126899	All targets in OG5_126899
Schistosoma japonicum	ko:K01651 acetolactate synthase [EC2.2.1.6], putative	Get druggable targets OG5_126899	All targets in OG5_126899
Schistosoma mansoni	acetolactate synthase	Get druggable targets OG5_126899	All targets in OG5_126899
Mycobacterium tuberculosis	Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase)	Get druggable targets OG5_126899	All targets in OG5_126899
Candida albicans	Acetolactate synthase	Get druggable targets OG5_126899	All targets in OG5_126899
Loa Loa (eye worm)	thiamine pyrophosphate enzyme	Get druggable targets OG5_126899	All targets in OG5_126899
Mycobacterium leprae	Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS)	Get druggable targets OG5_126899	All targets in OG5_126899
Brugia malayi	Thiamine pyrophosphate enzyme, central domain containing protein	Get druggable targets OG5_126899	All targets in OG5_126899
Mycobacterium ulcerans	putative oxalyl-CoA decarboxylase	Get druggable targets OG5_126899	All targets in OG5_126899
Candida albicans	Acetolactate synthase	Get druggable targets OG5_126899	All targets in OG5_126899
Schistosoma mansoni	acetolactate synthase	Get druggable targets OG5_126899	All targets in OG5_126899
Loa Loa (eye worm)	ILVBL protein	Get druggable targets OG5_126899	All targets in OG5_126899
Mycobacterium leprae	PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE)	Get druggable targets OG5_126899	All targets in OG5_126899
Schistosoma japonicum	ko:K01651 acetolactate synthase [EC2.2.1.6], putative	Get druggable targets OG5_126899	All targets in OG5_126899
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_126899	All targets in OG5_126899

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	thiamine pyrophosphate enzyme	0.0076	0.2542	0.684
Onchocerca volvulus		0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0067	0.1321	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.1321	0.5
Echinococcus multilocularis	activated cdc42 kinase 1	0.0067	0.1321	0.5
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0067	0.1321	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5
Echinococcus multilocularis	protein tyrosine kinase	0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5
Plasmodium vivax	acyl-CoA synthetase, putative	0.0076	0.2525	1
Onchocerca volvulus		0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	STE family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase shark	0.0067	0.1321	0.5
Trypanosoma brucei	Pseudokinase, putative	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	activin receptor type	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0067	0.1321	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0067	0.1321	0.5
Giardia lamblia	Kinase	0.0067	0.1321	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0067	0.1321	0.5
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine kinase	0.0067	0.1321	0.5
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0067	0.1321	0.5
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0067	0.1321	0.5
Echinococcus multilocularis	c src tyrosine kinase	0.0067	0.1321	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	insulin receptor	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	kinase suppressor of Ras 1	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0067	0.1321	0.5
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine kinase	0.0067	0.1321	0.5
Plasmodium falciparum	acyl-CoA synthetase	0.0076	0.2525	1
Echinococcus multilocularis	protein kinase	0.0067	0.1321	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0067	0.1321	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0067	0.1321	0.5
Leishmania major	putative pyruvate/indole-pyruvate carboxylase, putative	0.0076	0.2525	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5
Toxoplasma gondii	protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	activin receptor type	0.0067	0.1321	0.5
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	raf serine:threonine protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0067	0.1321	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0067	0.1321	0.5
Mycobacterium leprae	Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS)	0.0133	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Onchocerca volvulus	Tyrosine kinase homolog	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5
Entamoeba histolytica	protein kinase, putative	0.0074	0.2324	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0067	0.1321	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0067	0.1321	0.5
Giardia lamblia	Protein 21.1	0.0067	0.1321	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	ephrin type A receptor 4 A	0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0067	0.1321	0.5
Echinococcus granulosus	natriuretic peptide receptor 1	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0067	0.1321	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0067	0.1321	0.5
Echinococcus granulosus	protein tyrosine kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0067	0.1321	0.5
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0067	0.1321	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0067	0.1321	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.0067	0.1321	0.5
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0074	0.2324	1
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0067	0.1321	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0067	0.1321	0.5
Echinococcus multilocularis	heat shock protein 70	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0067	0.1321	0.5
Echinococcus granulosus	insulin receptor	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.1321	0.5
Trypanosoma cruzi	protein kinase, putative	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0067	0.1321	0.5
Echinococcus multilocularis	FL cytokine receptor	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0067	0.1321	0.5
Echinococcus granulosus	integrin linked protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0067	0.1321	0.5
Echinococcus granulosus	c src tyrosine kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0067	0.1321	0.5
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	integrin linked protein kinase	0.0067	0.1321	0.5
Giardia lamblia	Kinase, NEK	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0067	0.1321	0.5
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase	0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5
Giardia lamblia	Kinase, NEK	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0067	0.1321	0.5
Trypanosoma brucei	protein kinase, putative	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0067	0.1321	0.5
Echinococcus multilocularis	transfer RNA-Thr	0.0067	0.1321	0.5
Mycobacterium ulcerans	acetolactate synthase 1 catalytic subunit	0.0133	1	1
Echinococcus granulosus	receptor type guanylyl cyclase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0067	0.1321	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0067	0.1321	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0067	0.1321	0.5
Entamoeba histolytica	hypothetical protein	0.0074	0.2324	1
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.0067	0.1321	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0067	0.1321	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TK family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.1321	0.5
Mycobacterium ulcerans	hypothetical protein	0.0133	1	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0067	0.1321	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0067	0.1321	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase pr2	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0067	0.1321	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.1321	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0067	0.1321	0.5
Trypanosoma cruzi	protein kinase, putative	0.0067	0.1321	0.5
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0067	0.1321	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine kinase	0.0067	0.1321	0.5
Loa Loa (eye worm)	ILVBL protein	0.008	0.3106	1
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0067	0.1321	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Entamoeba histolytica	hypothetical protein	0.0074	0.2324	1
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0067	0.1321	0.5
Toxoplasma gondii	STE kinase	0.0067	0.1321	0.5
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	protein kinase	0.0067	0.1321	0.5
Mycobacterium tuberculosis	Probable oxalyl-CoA decarboxylase OxcA	0.0133	1	1
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0067	0.1321	0.5
Mycobacterium leprae	PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE)	0.0133	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0067	0.1321	0.5
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0067	0.1321	0.5
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0067	0.1321	0.5
Onchocerca volvulus		0.0067	0.1321	0.5
Schistosoma mansoni	acetolactate synthase	0.0114	0.7458	1
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0067	0.1321	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0067	0.1321	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0067	0.1321	0.5
Entamoeba histolytica	hypothetical protein	0.0074	0.2324	1
Echinococcus granulosus	protein kinase	0.0067	0.1321	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0067	0.1321	0.5
Mycobacterium ulcerans	putative oxalyl-CoA decarboxylase	0.0133	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0067	0.1321	0.5
Mycobacterium tuberculosis	Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS)	0.0133	1	1
Schistosoma mansoni	acetolactate synthase	0.0114	0.7458	1
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0067	0.1321	0.5
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0067	0.1321	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0067	0.1321	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 17.1 nM	Inhibition of wild type Nicotiana tabacum (tobacco) GST-tagged acetolactate synthase expressed in Escherichia coli by modified Westerfeld method	ChEMBL.	10329466
IC50 (binding)	= 16.5 uM	Inhibition of wild type Nicotiana tabacum (tobacco) S4-Hra GST-tagged acetolactate synthase mutant expressed in Escherichia coli by modified Westerfeld method	ChEMBL.	10329466

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2269029

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1841730