Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | Starlite/ChEMBL | No references |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Schistosoma japonicum | 5-hydroxytryptamine receptor, putative | Get druggable targets OG5_133680 | All targets in OG5_133680 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133680 | All targets in OG5_133680 |
Schistosoma japonicum | ko:K04165 Oamb gene product from transcript, putative | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | AT19640p | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | 390 aa | 335 aa | 21.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.3421 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0.0144 | 0.0144 |
Trypanosoma brucei | Prostaglandin E synthase | 0.3421 | 1 | 0.5 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0363 | 0.0144 | 0.5 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.3421 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3421 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0.0144 | 0.0144 |
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.3421 | 1 | 0.5 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.3421 | 1 | 0.5 |
Toxoplasma gondii | prostaglandin-E synthase | 0.3421 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1238 nM | Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay | ChEMBL. | No reference |
Ki (binding) | = 1249 nM | Binding affinity to Homo sapiens (human) 5HT1B receptor by radioligand binding assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.