Detailed information for compound 1842279

Basic information

Technical information
  • TDR Targets ID: 1842279
  • Name: 1-methoxy-2-prop-2-enyl-4-propoxybenzene
  • MW: 206.281 | Formula: C13H18O2
  • H donors: 0 H acceptors: 0 LogP: 3.83 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCOc1ccc(c(c1)CC=C)OC
  • InChi: 1S/C13H18O2/c1-4-6-11-10-12(15-9-5-2)7-8-13(11)14-3/h4,7-8,10H,1,5-6,9H2,2-3H3
  • InChiKey: HRQYZNPNHWCOQG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-allyl-1-methoxy-4-propoxy-benzene
  • 2-allyl-1-methoxy-4-propoxybenzene
  • 1-methoxy-2-prop-2-enyl-4-propoxy-benzene

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi polo-like protein kinase, putative 0.0107 0.4729 0.9833
Schistosoma mansoni calcium-activated potassium channel 0.0204 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.1786 0.3777
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0107 0.4729 0.4729
Echinococcus multilocularis dual specificity 0.0109 0.4809 0.4809
Giardia lamblia Kinase, PLK 0.0107 0.4729 0.5
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0109 0.4809 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0107 0.4729 0.9833
Loa Loa (eye worm) transcription factor SMAD2 0.0078 0.3153 0.3153
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0026 0.0264 0.0264
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0026 0.0264 0.0264
Echinococcus multilocularis lysosomal alpha glucosidase 0.0093 0.396 0.396
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0109 0.4809 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0026 0.0264 0.0548
Echinococcus multilocularis lysosomal alpha glucosidase 0.0093 0.396 0.396
Entamoeba histolytica hypothetical protein 0.0109 0.4809 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.4759 0.4759
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.4809 0.4809
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0026 0.0264 0.0264
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.1786 0.3777
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0107 0.4729 0.9833
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0026 0.0264 0.0264
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0026 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0204 1 1
Entamoeba histolytica protein kinase, putative 0.0109 0.4809 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0026 0.0264 0.0264
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.4729 1
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.4729 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0021 0 0.5
Echinococcus granulosus dual specificity 0.0109 0.4809 0.4809
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0107 0.4729 0.4729
Trypanosoma brucei polo-like protein kinase 0.0107 0.4729 0.9833
Schistosoma mansoni kinase 0.0055 0.1863 0.1863
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.4729 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0107 0.4729 0.4729
Loa Loa (eye worm) hypothetical protein 0.0039 0.1001 0.1001
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0093 0.396 0.396
Schistosoma mansoni hypothetical protein 0.0204 0.9996 0.9996
Loa Loa (eye worm) hypothetical protein 0.0108 0.4759 0.4759
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.4729 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0107 0.4729 0.9833
Echinococcus multilocularis small conductance calcium activated potassium 0.0204 1 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0093 0.396 0.8235
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.4729 0.4729
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0026 0.0264 0.0264
Schistosoma mansoni alpha-glucosidase 0.008 0.3251 0.3251
Schistosoma mansoni calcium-activated potassium channel 0.0157 0.7431 0.7431
Entamoeba histolytica protein kinase domain containing protein 0.0109 0.4809 1
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.4729 1
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0109 0.4809 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0026 0.0264 0.0264
Echinococcus granulosus geminin 0.0204 0.9996 0.9996
Loa Loa (eye worm) hypothetical protein 0.0074 0.2919 0.2919
Schistosoma mansoni hypothetical protein 0.0204 0.9996 0.9996
Echinococcus multilocularis geminin 0.0204 0.9996 0.9996
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.4729 1
Brugia malayi MH2 domain containing protein 0.0078 0.3153 0.6557
Echinococcus granulosus lysosomal alpha glucosidase 0.0093 0.396 0.396
Onchocerca volvulus Serine\/threonine kinase homolog 0.0107 0.4729 1
Schistosoma mansoni hypothetical protein 0.0204 1 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0109 0.4809 1
Schistosoma mansoni alpha-glucosidase 0.008 0.3251 0.3251
Loa Loa (eye worm) MH2 domain-containing protein 0.0078 0.3153 0.3153
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.4729 1
Entamoeba histolytica protein kinase, putative 0.0109 0.4809 1
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0109 0.4809 0.4809
Brugia malayi serine/threonine-protein kinase plk-2 0.0107 0.4729 0.9833
Brugia malayi Protein kinase domain containing protein 0.0109 0.4809 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.3382 0.3382

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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