Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | aldehyde oxidase, putative | 0.0773 | 0.1413 | 0.5 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0364 | 0.049 | 0.5951 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.0261 | 0.0256 | 0.3111 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0773 | 0.1413 | 0.5 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0229 | 0.0184 | 0.2238 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.0261 | 0.0256 | 0.3111 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0773 | 0.1413 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4572 | 1 | 0.5 |
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.4572 | 1 | 0.5 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.4572 | 1 | 0.5 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.0364 | 0.049 | 0.5951 |
Onchocerca volvulus | 0.4572 | 1 | 0.5 | |
Toxoplasma gondii | prostaglandin-E synthase | 0.4572 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (medium chain) | 0.0261 | 0.0256 | 0.5229 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.4572 | 1 | 0.5 |
Trypanosoma brucei | Prostaglandin E synthase | 0.4572 | 1 | 0.5 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.0512 | 0.0823 | 1 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.0364 | 0.049 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.