Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | gamma-secretase subunit pen-2 | 0.2557 | 0.2812 | 0.211 |
Toxoplasma gondii | hypothetical protein | 0.1247 | 0.089 | 1 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.356 | 0.4284 | 0.5 |
Echinococcus multilocularis | presenilin | 0.356 | 0.4284 | 0.3643 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.2557 | 0.2812 | 0.2006 |
Brugia malayi | Presenilin family protein | 0.356 | 0.4284 | 0.3726 |
Echinococcus granulosus | presenilin | 0.356 | 0.4284 | 0.3643 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.7456 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2389 | 0.2565 | 0.2565 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.7456 | 1 | 1 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.7456 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1283 | 0.0943 | 0.0943 |
Schistosoma mansoni | hypothetical protein | 0.1328 | 0.1008 | 0.0351 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.356 | 0.4284 | 1 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.356 | 0.4284 | 1 |
Trypanosoma brucei | Aph-1 protein, putative | 0.2905 | 0.3323 | 0.7652 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.356 | 0.4284 | 1 |
Trypanosoma brucei | presenilin-like aspartic peptidase, putative | 0.356 | 0.4284 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1328 | 0.1008 | 0.1008 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.356 | 0.4284 | 0.3866 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.2557 | 0.2812 | 0.2812 |
Echinococcus granulosus | presenilin enhancer 2 | 0.2557 | 0.2812 | 0.2006 |
Loa Loa (eye worm) | presenilin spe-4 | 0.1247 | 0.089 | 0.089 |
Brugia malayi | hypothetical protein | 0.1328 | 0.1008 | 0.013 |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.3031 | 0.3507 | 0.2874 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.356 | 0.4284 | 1 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.7456 | 1 | 1 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.356 | 0.4284 | 1 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.356 | 0.4284 | 1 |
Brugia malayi | hypothetical protein | 0.1328 | 0.1008 | 0.013 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | Phytotoxicity against Oryza sativa cv. Koshihikari (rice) at 500 g a.i/ha measured after 14 days | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.