Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Cytochrome P450 17A1 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 17, subfamily A, polypeptide 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0189 | 0.2624 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0111 | 0.1365 | 0.5201 |
Schistosoma mansoni | CREB-binding protein 1 (SmCBP1) | 0.0114 | 0.1407 | 0.2094 |
Toxoplasma gondii | hypothetical protein | 0.0103 | 0.1236 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0111 | 0.1365 | 0.2011 |
Mycobacterium ulcerans | hypothetical protein | 0.0338 | 0.5054 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0154 | 0.2057 | 0.3363 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0189 | 0.2624 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0058 | 0.0498 | 0.0498 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.009 | 0.102 | 0.0549 |
Onchocerca volvulus | 0.0189 | 0.2624 | 1 | |
Brugia malayi | TAZ zinc finger family protein | 0.0114 | 0.1407 | 0.0103 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0362 | 0.5456 | 1 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0189 | 0.2624 | 0.4375 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0189 | 0.2624 | 1 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0189 | 0.2624 | 0.4851 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.009 | 0.102 | 0.0549 |
Schistosoma mansoni | CREB-binding protein 2 | 0.0114 | 0.1407 | 0.2094 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0303 | 0.4496 | 0.4207 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.011 | 0.1341 | 0.0887 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0111 | 0.1365 | 0.1168 |
Loa Loa (eye worm) | CBP-B | 0.0079 | 0.084 | 0.083 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0641 | 1 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0362 | 0.5456 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0058 | 0.0498 | 0.1897 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0362 | 0.5456 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0362 | 0.5456 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0189 | 0.2624 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0338 | 0.5054 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0303 | 0.4496 | 0.4496 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.009 | 0.102 | 0.0549 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0189 | 0.2624 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0111 | 0.1365 | 0.4499 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.013 | 0.1677 | 0.2843 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0058 | 0.0498 | 0.1897 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0111 | 0.1365 | 0.4499 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0111 | 0.1365 | 0.5 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0362 | 0.5456 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0111 | 0.1365 | 0.1873 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.0189 | 0.2624 | 0.3078 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0303 | 0.4496 | 0.4207 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0189 | 0.2624 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0111 | 0.1365 | 0.1168 |
Echinococcus granulosus | glycogen phosphorylase | 0.0111 | 0.1365 | 0.1406 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0641 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0111 | 0.1365 | 0.2011 |
Echinococcus granulosus | CREB binding protein | 0.0114 | 0.1407 | 0.1495 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0189 | 0.2624 | 1 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.009 | 0.102 | 0.0549 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0111 | 0.1365 | 0.1168 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0111 | 0.1365 | 0.1406 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0641 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0111 | 0.1365 | 0.5201 |
Echinococcus granulosus | glycogen phosphorylase | 0.0111 | 0.1365 | 0.1406 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0189 | 0.2624 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0189 | 0.2624 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0154 | 0.2057 | 0.1641 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1113 nM | Inhibition of human testicular microsomal Cytochrome P450 17A1 | ChEMBL. | 9379450 |
IC50 (binding) | = 1113 nM | Inhibition of human testicular microsomal Cytochrome P450 17A1 | ChEMBL. | 9379450 |
IC50 (binding) | = 1500 nM | Inhibition of rat testicual micrososmal Cytochrome P450 17A1 | ChEMBL. | 9379450 |
IC50 (binding) | = 1500 nM | Inhibition of rat testicual micrososmal Cytochrome P450 17A1 | ChEMBL. | 9379450 |
Inhibition (binding) | = 54 % | Percent inhibition of rat testicular microsomal Cytochrome P450 17A1 | ChEMBL. | 9379450 |
Inhibition (binding) | = 54 % | Percent inhibition of rat testicular microsomal Cytochrome P450 17A1 | ChEMBL. | 9379450 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.