Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0177 | 0.6576 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0127 | 0.3577 | 0.544 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0127 | 0.3577 | 0.544 |
Schistosoma mansoni | thyroid hormone receptor | 0.0127 | 0.3577 | 0.3577 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0127 | 0.3577 | 0.544 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0127 | 0.3577 | 0.544 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0127 | 0.3577 | 0.544 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0127 | 0.3577 | 0.544 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.3577 | 0.544 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0127 | 0.3577 | 0.544 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0127 | 0.3577 | 0.544 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.3577 | 0.544 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0177 | 0.6576 | 0.6576 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0127 | 0.3577 | 0.544 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0127 | 0.3577 | 0.544 |
Schistosoma mansoni | nuclear hormone receptor | 0.0127 | 0.3577 | 0.3577 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0127 | 0.3577 | 0.544 |
Brugia malayi | Protein kinase domain containing protein | 0.0177 | 0.6576 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0127 | 0.3577 | 0.3577 |
Schistosoma mansoni | thyroid hormone receptor | 0.0127 | 0.3577 | 0.3577 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0177 | 0.6576 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0127 | 0.3577 | 0.544 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0127 | 0.3577 | 0.544 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0127 | 0.3577 | 0.544 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0127 | 0.3577 | 0.544 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0127 | 0.3577 | 0.544 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0127 | 0.3577 | 0.544 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0127 | 0.3577 | 0.544 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0127 | 0.3577 | 0.544 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0127 | 0.3577 | 0.544 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0127 | 0.3577 | 0.544 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0127 | 0.3577 | 0.544 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0127 | 0.3577 | 0.3577 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0177 | 0.6576 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0127 | 0.3577 | 0.3577 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0127 | 0.3577 | 0.3577 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0127 | 0.3577 | 0.544 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0127 | 0.3577 | 0.544 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0127 | 0.3577 | 0.544 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0127 | 0.3577 | 0.544 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.3577 | 0.544 |
Brugia malayi | steroid hormone receptor | 0.0127 | 0.3577 | 0.544 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0127 | 0.3577 | 0.3577 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0127 | 0.3577 | 0.544 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0127 | 0.3577 | 0.544 |
Echinococcus granulosus | FTZ F1 alpha | 0.0127 | 0.3577 | 0.544 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0177 | 0.6576 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0127 | 0.3577 | 0.544 |
Schistosoma mansoni | coup transcription factor | 0.0127 | 0.3577 | 0.3577 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0127 | 0.3577 | 0.544 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0127 | 0.3577 | 0.544 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0177 | 0.6576 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0127 | 0.3577 | 0.544 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0127 | 0.3577 | 0.544 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0127 | 0.3577 | 0.544 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0127 | 0.3577 | 0.544 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.3577 | 0.544 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0127 | 0.3577 | 0.3577 |
Brugia malayi | nuclear hormone receptor | 0.0127 | 0.3577 | 0.544 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0127 | 0.3577 | 0.3577 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0127 | 0.3577 | 0.544 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.3577 | 0.544 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0127 | 0.3577 | 0.544 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0127 | 0.3577 | 0.3577 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0127 | 0.3577 | 0.544 |
Brugia malayi | nuclear receptor NHR-88 | 0.0127 | 0.3577 | 0.544 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.3577 | 0.544 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0127 | 0.3577 | 0.3577 |
Brugia malayi | ecdysteroid receptor | 0.0127 | 0.3577 | 0.544 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.3577 | 0.544 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0127 | 0.3577 | 0.544 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.3577 | 0.544 |
Trypanosoma brucei | RNA helicase, putative | 0.0235 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0127 | 0.3577 | 0.544 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0177 | 0.6576 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0127 | 0.3577 | 0.544 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | Antifungal activity against Candida-51 after 72 to 96 hr by two-fold serial dilution method | ChEMBL. | No reference | |
MIC (functional) | Antibacterial activity against Escherichia coli after 24 hr by two-fold serial dilution method | ChEMBL. | No reference | |
MIC (functional) | = 100 ug ml-1 | Antifungal activity against Candida-6 after 72 to 96 hr by two-fold serial dilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.