Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APH1B gamma secretase subunit | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Brugia malayi | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus granulosus | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma japonicum | ko:K06172 anterior pharynx defective 1, putative | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | casein kinase ii subunit beta | 0.3069 | 0.5326 | 0.5326 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3069 | 0.5326 | 0.4717 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3069 | 0.5326 | 0.4717 |
Trypanosoma brucei | Casein kinase II | 0.5503 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3069 | 0.5326 | 0.4717 |
Schistosoma mansoni | protein kinase | 0.5503 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3069 | 0.5326 | 0.4717 |
Plasmodium vivax | unspecified product | 0.5503 | 1 | 1 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.5503 | 1 | 1 |
Giardia lamblia | Casein kinase II beta chain | 0.3069 | 0.5326 | 0.4717 |
Trichomonas vaginalis | CMGC family protein kinase | 0.5503 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3069 | 0.5326 | 0.4717 |
Brugia malayi | Csnk2b protein | 0.3069 | 0.5326 | 0.5326 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3069 | 0.5326 | 0.4717 |
Leishmania major | casein kinase II, putative | 0.5503 | 1 | 1 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.3069 | 0.5326 | 0.4717 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.5503 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3069 | 0.5326 | 0.4717 |
Loa Loa (eye worm) | casein kinase II | 0.0897 | 0.1154 | 0.1154 |
Echinococcus granulosus | casein kinase ii subunit beta | 0.3069 | 0.5326 | 0.5326 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3069 | 0.5326 | 0.4717 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.5503 | 1 | 1 |
Trypanosoma cruzi | casein kinase II, putative | 0.5503 | 1 | 1 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.5503 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.5503 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.5503 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3069 | 0.5326 | 0.4717 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.3069 | 0.5326 | 0.4717 |
Trichomonas vaginalis | CMGC family protein kinase | 0.5503 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3069 | 0.5326 | 0.4717 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.3069 | 0.5326 | 0.5 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3069 | 0.5326 | 0.4717 |
Trichomonas vaginalis | CMGC family protein kinase | 0.5503 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.5503 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.5503 | 1 | 1 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.5503 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3069 | 0.5326 | 0.4717 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3069 | 0.5326 | 0.4717 |
Entamoeba histolytica | casein kinase, putative | 0.5503 | 1 | 1 |
Giardia lamblia | Kinase, CMGC CK2 | 0.5503 | 1 | 1 |
Schistosoma mansoni | casein kinase II beta subunit | 0.3069 | 0.5326 | 0.5326 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.3069 | 0.5326 | 0.5 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3069 | 0.5326 | 0.4717 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.3069 | 0.5326 | 0.4717 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3069 | 0.5326 | 0.4717 |
Loa Loa (eye worm) | Csnk2b protein | 0.3069 | 0.5326 | 0.5326 |
Entamoeba histolytica | protein kinase domain containing protein | 0.5503 | 1 | 1 |
Brugia malayi | casein kinase II, putaitve | 0.0897 | 0.1154 | 0.1154 |
Trichomonas vaginalis | CMGC family protein kinase | 0.5503 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.18 uM | Modulation of gamma-secretase in HEK293 cells expressing guinea pig Swedish mutant SFV-APP695sw assessed as inhibition of amyloid beta-42 production after 16 to 18 hrs by HTRF assay | ChEMBL. | 24139583 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.