Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0465 | 0.152 | 0.1574 |
Brugia malayi | hypothetical protein | 0.0262 | 0.075 | 0.075 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0097 | 0.0124 | 0.0124 |
Schistosoma mansoni | DNA topoisomerase II | 0.0216 | 0.0575 | 0.0575 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0007 | 0.0007 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.018 | 0.0439 | 0.0133 |
Echinococcus multilocularis | integrin beta 2 | 0.0225 | 0.0607 | 0.0607 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0183 | 0.045 | 0.045 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase alpha subunit | 0.27 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ribonucleotide-diphosphate reductase subunit alpha | 0.2352 | 0.8678 | 1 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0183 | 0.045 | 0.045 |
Mycobacterium leprae | conserved hypothetical protein | 0.0348 | 0.1077 | 0.1052 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.007 | 0.002 | 0.002 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0097 | 0.0124 | 0.0124 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.018 | 0.0439 | 0.0309 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0007 | 0.0007 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.0721 | 0.2492 | 0.2252 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0216 | 0.0575 | 0.0273 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0262 | 0.075 | 0.075 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0303 | 0.0906 | 0.0906 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0353 | 0.1096 | 0.0811 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.007 | 0.002 | 0.002 |
Loa Loa (eye worm) | integrin beta-2 | 0.0303 | 0.0906 | 0.0906 |
Schistosoma mansoni | polycystin 1-related | 0.0262 | 0.075 | 0.075 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0358 | 0.0049 |
Chlamydia trachomatis | transcriptional repressor NrdR | 0.0348 | 0.1077 | 0.0958 |
Mycobacterium ulcerans | ribonucleotide-diphosphate reductase subunit alpha | 0.2352 | 0.8678 | 1 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.0134 | 0.0134 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0956 | 0.3381 | 0.3764 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.018 | 0.0439 | 0.0133 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0216 | 0.0575 | 0.766 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0465 | 0.152 | 0.1249 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0131 | 0.0131 |
Echinococcus multilocularis | thymidylate synthase | 0.0113 | 0.0183 | 0.0183 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0262 | 0.075 | 0.075 |
Brugia malayi | hypothetical protein | 0.0262 | 0.075 | 0.075 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0097 | 0.0124 | 0.0124 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.018 | 0.0439 | 0.0309 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0358 | 0.0227 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.002 | 0.002 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0262 | 0.075 | 0.0454 |
Onchocerca volvulus | 0.0262 | 0.075 | 1 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.007 | 0.002 | 0.002 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0159 | 0.0358 | 0.0049 |
Mycobacterium tuberculosis | Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) | 0.0845 | 0.2963 | 0.3272 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain, putative | 0.0146 | 0.031 | 0.0178 |
Echinococcus multilocularis | Kelch repeat type 1 | 0.0184 | 0.0452 | 0.0452 |
Giardia lamblia | DNA topoisomerase II | 0.02 | 0.0515 | 0.5 |
Mycobacterium leprae | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) | 0.2352 | 0.8678 | 1 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0956 | 0.3381 | 0.3169 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0216 | 0.0575 | 0.0273 |
Loa Loa (eye worm) | ribonucleoside-diphosphate reductase large subunit | 0.27 | 1 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0216 | 0.0575 | 0.766 |
Echinococcus granulosus | integrin beta 2 | 0.0225 | 0.0607 | 0.0607 |
Schistosoma mansoni | rab6-interacting | 0.0262 | 0.075 | 0.075 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0216 | 0.0575 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0358 | 0.0049 |
Trichomonas vaginalis | ribonucleoside-diphosphate reductase alpha chain, putative | 0.2352 | 0.8678 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0137 | 0.0276 | 0.0109 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0456 | 0.1483 | 0.153 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0216 | 0.0575 | 0.0575 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0358 | 0.0049 |
Loa Loa (eye worm) | ribonucleotide reductase M2 B | 0.0146 | 0.031 | 0.031 |
Echinococcus granulosus | ribonucleoside diphosphate reductase large | 0.27 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0113 | 0.0183 | 0.0183 |
Leishmania major | DNA topoisomerase ii | 0.018 | 0.0439 | 0.0133 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase subunit | 0.0146 | 0.031 | 0.031 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0063 | 0.0063 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0465 | 0.152 | 0.1574 |
Schistosoma mansoni | integrin beta subunit | 0.0179 | 0.0432 | 0.0432 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0066 | 0.0007 | 0.0007 |
Brugia malayi | Doublecortin family protein | 0.0262 | 0.075 | 0.075 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0956 | 0.3381 | 0.3169 |
Brugia malayi | hypothetical protein | 0.007 | 0.002 | 0.002 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0216 | 0.0575 | 0.0575 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0328 | 0.0999 | 0.088 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0216 | 0.0575 | 0.766 |
Schistosoma mansoni | lipoxygenase | 0.157 | 0.5711 | 0.5711 |
Mycobacterium ulcerans | transcriptional regulator NrdR | 0.0348 | 0.1077 | 0.1052 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0254 | 0.0719 | 0.0422 |
Onchocerca volvulus | 0.0113 | 0.0183 | 0.2441 | |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0956 | 0.3381 | 0.3764 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase large subunit, putative | 0.27 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0131 | 0.0131 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.157 | 0.5711 | 0.5711 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0956 | 0.3381 | 0.3169 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein NrdR | 0.0348 | 0.1077 | 0.1052 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0216 | 0.0575 | 0.0575 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0146 | 0.031 | 0.0178 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase small chain | 0.0146 | 0.031 | 0.031 |
Onchocerca volvulus | 0.0262 | 0.075 | 1 | |
Trypanosoma brucei | ribonucleoside-diphosphate reductase large chain | 0.27 | 1 | 1 |
Leishmania major | ribonucleoside-diphosphate reductase large chain, putative | 0.27 | 1 | 1 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.27 | 1 | 1 |
Brugia malayi | ribonucleotide reductase 2 | 0.0146 | 0.031 | 0.031 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0183 | 0.045 | 0.045 |
Plasmodium vivax | ribonucleoside-diphosphate reductase large chain, putative | 0.27 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0113 | 0.0183 | 0.0183 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) | 0.0146 | 0.031 | 0.0149 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) | 0.2352 | 0.8678 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0216 | 0.0575 | 0.0575 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0465 | 0.152 | 0.1249 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase large chain | 0.27 | 1 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0353 | 0.1096 | 0.0974 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0183 | 0.045 | 0.045 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0262 | 0.075 | 0.075 |
Loa Loa (eye worm) | hypothetical protein | 0.0883 | 0.3106 | 0.3106 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0216 | 0.0575 | 0.0273 |
Echinococcus multilocularis | RUN | 0.0262 | 0.075 | 0.075 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0421 | 0.1353 | 0.1353 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit alpha | 0.27 | 1 | 1 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0956 | 0.3381 | 0.3169 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0465 | 0.152 | 0.1249 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0216 | 0.0575 | 0.0575 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0146 | 0.031 | 0.0178 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0216 | 0.0575 | 0.0575 |
Loa Loa (eye worm) | hypothetical protein | 0.0883 | 0.3106 | 0.3106 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0358 | 0.0049 |
Schistosoma mansoni | serine-type protease inhibitor | 0.0442 | 0.1432 | 0.1432 |
Schistosoma mansoni | rab6-interacting | 0.0262 | 0.075 | 0.075 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.0452 | 0.0452 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit beta | 0.0146 | 0.031 | 0.0181 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0262 | 0.075 | 0.0454 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.075 | 0.075 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0113 | 0.0183 | 0.0183 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) | 0.0146 | 0.031 | 0.0149 |
Echinococcus granulosus | kelch ECH associated protein 1 | 0.0183 | 0.045 | 0.045 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0465 | 0.152 | 0.1407 |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit alpha | 0.27 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0113 | 0.0183 | 0.0183 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0146 | 0.031 | 0.0178 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0124 | 0.0124 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0262 | 0.075 | 0.075 |
Echinococcus granulosus | ribonucleoside diphosphate reductase subunit | 0.0146 | 0.031 | 0.031 |
Schistosoma mansoni | hypothetical protein | 0.0262 | 0.075 | 0.075 |
Schistosoma mansoni | loxhd1 | 0.0262 | 0.075 | 0.075 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.075 | 0.075 |
Echinococcus granulosus | RUN | 0.0262 | 0.075 | 0.075 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0353 | 0.1096 | 0.0811 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.157 | 0.5711 | 0.5711 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0956 | 0.3381 | 0.3293 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0262 | 0.075 | 0.075 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0353 | 0.1096 | 0.0811 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase large | 0.27 | 1 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0262 | 0.075 | 0.075 |
Schistosoma mansoni | serine-type protease inhibitor | 0.0442 | 0.1432 | 0.1432 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0063 | 0.0063 |
Schistosoma mansoni | lipoxygenase | 0.1097 | 0.3918 | 0.3918 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0956 | 0.3381 | 0.367 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0465 | 0.152 | 0.1446 |
Loa Loa (eye worm) | doublecortin family protein | 0.0262 | 0.075 | 0.075 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 16.6 % |
Compound (50 mM) was tested in vitro for inhibitory potency against Fas-associated phosphatase- 1 binding from HFAP-10cDNA subcloned into the bluescript vector pSK-II(Stratagene) |
ChEMBL. | 10464015 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.