Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.011 | 0.1437 | 0.5 |
Onchocerca volvulus | Alicorn homolog | 0.0096 | 0.1045 | 0.5 |
Loa Loa (eye worm) | loechrig isoform VII | 0.0336 | 0.782 | 0.7454 |
Loa Loa (eye worm) | hypothetical protein | 0.0413 | 1 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/AMPK protein kinase | 0.0231 | 0.4842 | 0.3976 |
Trypanosoma cruzi | SNF1-related protein kinase regulatory subunit beta, putative | 0.011 | 0.1437 | 0.5 |
Echinococcus multilocularis | 5' AMP activated protein kinase catalytic | 0.0231 | 0.4842 | 0.6192 |
Brugia malayi | EST embl|AI107989|AI107989 comes from the 3' UTR, putative | 0.0231 | 0.4842 | 0.3976 |
Toxoplasma gondii | 5'-AMP-activated protein kinase subunit beta-1 family protein, putative | 0.0065 | 0.0166 | 0.5 |
Echinococcus multilocularis | 5' AMP activated protein kinase subunit gamma | 0.0336 | 0.782 | 1 |
Echinococcus granulosus | 5' AMP activated protein kinase subunit gamma | 0.0336 | 0.782 | 1 |
Echinococcus granulosus | AMPK beta subunit | 0.011 | 0.1437 | 0.1838 |
Trypanosoma brucei | 5'-AMP-activated protein kinase subunit beta | 0.011 | 0.1437 | 0.5 |
Schistosoma mansoni | protein kinase subunit beta | 0.011 | 0.1437 | 0.1838 |
Echinococcus multilocularis | 5' AMP activated protein kinase subunit gamma | 0.0309 | 0.7053 | 0.9019 |
Echinococcus multilocularis | AMPK beta subunit | 0.011 | 0.1437 | 0.1838 |
Echinococcus granulosus | 5' AMP activated protein kinase catalytic | 0.0231 | 0.4842 | 0.6192 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0231 | 0.4842 | 0.6192 |
Giardia lamblia | 5-AMP-activated protein kinase, gamma-1 subunit | 0.0336 | 0.782 | 1 |
Schistosoma mansoni | protein kinase subunit gamma | 0.0336 | 0.782 | 1 |
Trypanosoma cruzi | 5'-AMP-activated protein kinase subunit beta, putative | 0.011 | 0.1437 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0403 | 0.9691 | 0.964 |
Brugia malayi | loechrig isoform VII | 0.0336 | 0.782 | 0.7454 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 4.5 | Cytotoxicity against Homo sapiens (human) CAKI-1 cells after 48 hr by SRB assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.