Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | retinoic acid receptor RXR | 0.0267 | 0.5157 | 0.5157 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0385 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0385 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0385 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0267 | 0.5157 | 0.5157 |
Loa Loa (eye worm) | hypothetical protein | 0.0385 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0267 | 0.5157 | 0.5157 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0267 | 0.5157 | 0.5157 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0267 | 0.5157 | 0.5157 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0385 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0385 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0385 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0385 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0385 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0267 | 0.5157 | 0.5157 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0385 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0385 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0267 | 0.5157 | 0.5157 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0267 | 0.5157 | 0.5157 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0385 | 1 | 1 |
Echinococcus multilocularis | Mastin | 0.0385 | 1 | 1 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0385 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0267 | 0.5157 | 0.5157 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0267 | 0.5157 | 0.5157 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0267 | 0.5157 | 0.5157 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0385 | 1 | 1 |
Echinococcus granulosus | enteropeptidase | 0.0385 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0267 | 0.5157 | 0.5157 |
Onchocerca volvulus | 0.0385 | 1 | 1 | |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0267 | 0.5157 | 0.5157 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0267 | 0.5157 | 0.5157 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0267 | 0.5157 | 0.5157 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0267 | 0.5157 | 0.5157 |
Onchocerca volvulus | 0.0385 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0385 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0267 | 0.5157 | 0.5157 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0385 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0267 | 0.5157 | 0.5157 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0267 | 0.5157 | 0.5157 |
Schistosoma mansoni | nuclear hormone receptor | 0.0267 | 0.5157 | 0.5157 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0385 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0385 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.5157 | 0.5157 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.5157 | 0.5157 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0267 | 0.5157 | 0.5157 |
Brugia malayi | steroid hormone receptor | 0.0267 | 0.5157 | 0.5157 |
Loa Loa (eye worm) | hypothetical protein | 0.0385 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0267 | 0.5157 | 0.5157 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0267 | 0.5157 | 0.5157 |
Onchocerca volvulus | 0.0385 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.5157 | 0.5157 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0267 | 0.5157 | 0.5157 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.5157 | 0.5157 |
Loa Loa (eye worm) | trypsin family protein | 0.0385 | 1 | 1 |
Echinococcus multilocularis | enteropeptidase | 0.0385 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0385 | 1 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0385 | 1 | 1 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0385 | 1 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0267 | 0.5157 | 0.5157 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0267 | 0.5157 | 0.5157 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0267 | 0.5157 | 0.5157 |
Mycobacterium ulcerans | hypothetical protein | 0.0385 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0267 | 0.5157 | 0.5157 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0267 | 0.5157 | 0.5157 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0385 | 1 | 1 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0385 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0267 | 0.5157 | 0.5157 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0267 | 0.5157 | 0.5157 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0267 | 0.5157 | 0.5157 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0267 | 0.5157 | 0.5157 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0267 | 0.5157 | 0.5157 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0267 | 0.5157 | 0.5157 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0267 | 0.5157 | 0.5157 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0267 | 0.5157 | 0.5157 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.5157 | 0.5157 |
Onchocerca volvulus | 0.0385 | 1 | 1 | |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0267 | 0.5157 | 0.5157 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0385 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0385 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.0385 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0267 | 0.5157 | 0.5157 |
Onchocerca volvulus | 0.0385 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.5157 | 0.5157 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0267 | 0.5157 | 0.5157 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0267 | 0.5157 | 0.5157 |
Schistosoma mansoni | thyroid hormone receptor | 0.0267 | 0.5157 | 0.5157 |
Echinococcus granulosus | Mastin | 0.0385 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0267 | 0.5157 | 0.5157 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0385 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0267 | 0.5157 | 0.5157 |
Loa Loa (eye worm) | hypothetical protein | 0.0385 | 1 | 1 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0385 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0267 | 0.5157 | 0.5157 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0385 | 1 | 1 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0385 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0267 | 0.5157 | 0.5157 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0267 | 0.5157 | 0.5157 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0385 | 1 | 1 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0385 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0267 | 0.5157 | 0.5157 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0267 | 0.5157 | 0.5157 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0385 | 1 | 1 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0385 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0385 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.0385 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.0385 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0267 | 0.5157 | 0.5157 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0267 | 0.5157 | 0.5157 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0385 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.5157 | 0.5157 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0385 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0267 | 0.5157 | 0.5157 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0267 | 0.5157 | 0.5157 |
Onchocerca volvulus | 0.0385 | 1 | 1 | |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0267 | 0.5157 | 0.5157 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.5157 | 0.5157 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0385 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0267 | 0.5157 | 0.5157 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0267 | 0.5157 | 0.5157 |
Echinococcus granulosus | FTZ F1 alpha | 0.0267 | 0.5157 | 0.5157 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0267 | 0.5157 | 0.5157 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.