Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein tyrosine kinase 6 | Starlite/ChEMBL | No references |
Homo sapiens | erb-b2 receptor tyrosine kinase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | protein tyrosine kinase 6 | 134 aa | 127 aa | 26.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.1025 | 0.0983 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0097 | 0.1051 | 0.1051 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.3243 | 0.3212 |
Echinococcus granulosus | epidermal growth factor receptor | 0.018 | 0.3186 | 0.3154 |
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 1 | 1 |
Loa Loa (eye worm) | glycogen synthase | 0.0182 | 0.3243 | 0.3212 |
Echinococcus granulosus | glycogen synthase | 0.0446 | 1 | 1 |
Brugia malayi | Glycogen synthase | 0.0182 | 0.3243 | 0.3212 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0097 | 0.1051 | 0.1009 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.1051 | 0.1009 |
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 1 | 1 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.018 | 0.3186 | 0.3154 |
Echinococcus multilocularis | glycogen synthase | 0.0446 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.018 | 0.3186 | 0.3154 |
Echinococcus multilocularis | insulin receptor | 0.0058 | 0.0046 | 0.0046 |
Giardia lamblia | Glycogen synthase, putative | 0.0446 | 1 | 0.5 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0058 | 0.0046 | 0.0046 |
Schistosoma mansoni | glycogen synthase | 0.0446 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.1025 | 0.0983 |
Brugia malayi | Glycogen synthase | 0.0182 | 0.3243 | 0.3212 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.1051 | 0.1009 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.018 | 0.3186 | 0.3186 |
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 1 | 1 |
Onchocerca volvulus | Glycogen synthase homolog | 0.0446 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 1 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.018 | 0.3186 | 0.3154 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.1025 | 0.0983 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0097 | 0.1051 | 0.1009 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9.2 nM | Inhibition of human recombinant GST-fused Brk expressed in baculovirus Sf9 insect cells using poly(Glu,Tyr) as substrate after 60 mins by scintillation counting | ChEMBL. | No reference |
IC50 (binding) | = 689 nM | Inhibition of human recombinant GST-fused HER2 expressed in baculovirus Sf9 insect cells using poly(Glu,Tyr) as substrate after 60 mins by scintillation counting | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.