Detailed view for GL50803_104031

Basic information

TDR Targets ID: 811749
Giardia lamblia, Glycogen synthase, putative
Source Database / ID:  GiardiaDB  

pI: 6.5843 | Length (AA): 753 | MW (Da): 85062 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05693   Glycogen synthase

Gene Ontology

Mouse over links to read term descriptions.
GO:0004373   glycogen (starch) synthase activity  
GO:0005978   glycogen biosynthetic process  

Metabolic Pathways

Starch and sucrose metabolism (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 750 4qlb (A) 25 639 30.00 0 1 1.08082 0.67
1 622 4qlb (A) 25 597 37.00 0 1 1.20883 -0.19
108 167 5jxz (A) 265 334 42.00 0.26 0.08 0.0374813 2.24
552 639 4n9w (A) 276 361 13.00 0.0075 0.01 0.310666 -1.01

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129425)

Species Accession Gene Product
Brugia malayi Bm1_53420   Glycogen synthase
Candida albicans CaO19.10788   UDP-glucose-starch glucosyltransferase
Candida albicans CaO19.3278   UDP-glucose-starch glucosyltransferase
Caenorhabditis elegans CELE_Y46G5A.31   Protein GSY-1
Dictyostelium discoideum DDB_G0267674   glycogen synthase
Drosophila melanogaster Dmel_CG6904   Glycogen synthase
Echinococcus granulosus EgrG_001029800   glycogen synthase
Echinococcus multilocularis EmuJ_001029800   glycogen synthase
Giardia lamblia GL50803_104031   Glycogen synthase, putative
Homo sapiens ENSG00000104812   glycogen synthase 1 (muscle)
Homo sapiens ENSG00000111713   glycogen synthase 2 (liver)
Loa Loa (eye worm) LOAG_15760   hypothetical protein
Loa Loa (eye worm) LOAG_10336   hypothetical protein
Loa Loa (eye worm) LOAG_15639   hypothetical protein
Loa Loa (eye worm) LOAG_14851   hypothetical protein
Loa Loa (eye worm) LOAG_15665   hypothetical protein
Loa Loa (eye worm) LOAG_15238   hypothetical protein
Mus musculus ENSMUSG00000003865   glycogen synthase 1, muscle
Mus musculus ENSMUSG00000030244   glycogen synthase 2
Onchocerca volvulus OVOC5473   Glycogen synthase homolog
Saccharomyces cerevisiae YLR258W   glycogen (starch) synthase GSY2
Saccharomyces cerevisiae YFR015C   glycogen (starch) synthase GSY1
Schistosoma japonicum Sjp_0026410   ko:K00693 glycogen(starch) synthase [EC2.4.1.11], putative
Schistosoma mansoni Smp_018260   glycogen synthase
Schmidtea mediterranea mk4.021144.02   Glycogen synthase
Schmidtea mediterranea mk4.005651.11   Glycogen synthase
Schmidtea mediterranea mk4.002176.03  
Schmidtea mediterranea mk4.002176.04   Probable glycogen

Essentiality

GL50803_104031 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y46G5A.31 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y46G5A.31 Caenorhabditis elegans larval lethal wormbase
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens glycogen synthase 1 (muscle) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0419 1 0.5
0.0507 1 0.5
0.0645 0.8035 0.5
0.143 1 1
0.052 1 1
0.0645 0.8035 0.5
0.0592 1 0.5
0.008 1 0.5
0.0624 0.9271 1
0.0624 0.9271 1
0.135 1 0.5
0.1016 0.6121 0.5
0.0446 1 0.5
0.0346 0.422 1
0.0099 0.5 0.5
0.0099 0.6095 1
0.0277 0.3614 0.8872
0.0519 1 0.5
0.0099 0.504 0.5
0.0597 1 1
0.0251 0.5651 0.5
0.1029 1 1
0.084 0.9776 0.5
0.0955 1 0.5
0.143 1 1
0.0589 1 0.5
0.0782 1 0.5
0.1437 1 0.5
0.0777 1 0.5
0.0634 0.8995 0.5
0.0528 0.5 0.5
0.0676 0.5 0.5
0.0691 0.5388 1
0.0356 1 0.5
0.0401 0.8219 1
0.0691 0.5388 1
0.0099 0.8207 1
0.0518 1 0.5
0.0266 1 0.5
0.0099 0.8207 1
0.143 1 1
0.121 1 0.5
0.0189 0.289 1
0.1699 1 0.5
0.0285 0.4237 1
0.1348 0.8999 0.5
0.0519 1 0.5
0.143 1 1
0.0586 1 1
0.0695 1 0.5
0.0099 0.5 0.5
0.1016 0.6121 0.5
0.0273 1 0.5
0.012 1 0.5
0.0676 0.5 0.5
0.0158 0.5765 0.6647
0.0099 0.5 0.5
0.055 1 0.5
0.0444 0.4771 0.5
0.0507 1 0.5
0.2183 1 1
0.0099 0.5 0.5
0.0266 1 0.5
0.0099 0.6675 1
0.0626 1 0.5
0.1699 1 0.5
0.0505 1 0.5
0.143 1 1
0.107 1 0.5
0.1348 0.8999 0.5
0.0437 1 0.5
0.1112 0.6524 1
0.2092 0.2979 1
0.121 1 0.5
0.012 0.3994 0.274
0.0444 0.4771 0.5
0.0773 1 0.5
0.143 1 1
0.0759 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier GL50803_104031 (Giardia lamblia), Glycogen synthase, putative
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