Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | geminin | 0.019 | 0.2281 | 0.3443 |
Giardia lamblia | Kinase, TTK | 0.0239 | 0.2925 | 1 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0239 | 0.2925 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0002 | 0.0003 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0519 | 0.6625 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0273 | 0.0273 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0707 | 0.0707 |
Schistosoma mansoni | phosphoglucomutase | 0.0092 | 0.0986 | 0.0986 |
Echinococcus multilocularis | tar DNA binding protein | 0.0071 | 0.0707 | 0.1068 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.0507 | 0.1734 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0092 | 0.0986 | 1 |
Echinococcus granulosus | geminin | 0.019 | 0.2281 | 0.3443 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0002 | 0.0002 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0302 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0302 | 0.0302 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0002 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0002 | 0.0002 |
Trypanosoma brucei | hypothetical protein, conserved | 0.011 | 0.1218 | 0.1218 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.2445 | 0.8356 |
Brugia malayi | RNase H family protein | 0.0092 | 0.0986 | 0.337 |
Loa Loa (eye worm) | TAR-binding protein | 0.0071 | 0.0707 | 0.2413 |
Trypanosoma brucei | unspecified product | 0.011 | 0.1218 | 0.1218 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0239 | 0.2925 | 0.2925 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0302 | 0.5 |
Echinococcus granulosus | ribonuclease H1 | 0.0092 | 0.0986 | 0.1488 |
Echinococcus multilocularis | ribonuclease H1 | 0.0092 | 0.0986 | 0.1488 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0239 | 0.2925 | 0.4416 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0302 | 0.0455 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0507 | 0.1728 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0092 | 0.0986 | 0.5 |
Brugia malayi | RNase H family protein | 0.0092 | 0.0986 | 0.337 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0519 | 0.6625 | 1 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0092 | 0.0986 | 0.337 |
Giardia lamblia | Ribonuclease H | 0.0092 | 0.0986 | 0.337 |
Loa Loa (eye worm) | TTK protein kinase | 0.0239 | 0.2925 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0002 | 0.0002 |
Brugia malayi | TAR-binding protein | 0.0071 | 0.0707 | 0.2418 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0071 | 0.0707 | 0.2413 |
Toxoplasma gondii | ribonuclease HI protein | 0.0092 | 0.0986 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.2281 | 0.2281 |
Mycobacterium tuberculosis | Possible maturase | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0239 | 0.2925 | 0.4416 |
Brugia malayi | N-terminal motif family protein | 0.0203 | 0.2445 | 0.8358 |
Brugia malayi | hypothetical protein | 0.004 | 0.0302 | 0.1031 |
Echinococcus granulosus | neuropeptide s receptor | 0.0519 | 0.6625 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0002 | 0.0007 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0002 | 0.0003 |
Loa Loa (eye worm) | RNA binding protein | 0.0071 | 0.0707 | 0.2413 |
Brugia malayi | RNase H family protein | 0.0092 | 0.0986 | 0.337 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0302 | 0.0302 |
Trypanosoma brucei | ingi protein (ORF1) | 0.011 | 0.1218 | 0.1218 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.011 | 0.1218 | 0.1218 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0002 | 0.0003 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0302 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0707 | 0.0707 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.0507 | 0.1728 |
Brugia malayi | RNA binding protein | 0.0071 | 0.0707 | 0.2418 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0203 | 0.2445 | 0.8358 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0273 | 0.0928 |
Trypanosoma brucei | ribonuclease H1 | 0.0092 | 0.0986 | 0.0986 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0002 | 0.0007 |
Echinococcus granulosus | tar DNA binding protein | 0.0071 | 0.0707 | 0.1068 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0002 | 0.0003 |
Schistosoma mansoni | phosphoglucomutase | 0.0092 | 0.0986 | 0.0986 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0092 | 0.0986 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.0507 | 0.1734 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0302 | 0.0455 |
Brugia malayi | Protein kinase domain containing protein | 0.0239 | 0.2925 | 1 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0092 | 0.0986 | 0.337 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0707 | 0.0707 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0302 | 0.5 |
Trypanosoma brucei | ingi protein (ORF1) | 0.011 | 0.1218 | 0.1218 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0239 | 0.2925 | 1 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0092 | 0.0986 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0707 | 0.0707 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0071 | 0.0707 | 0.2418 |
Trypanosoma brucei | RNA helicase, putative | 0.0774 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0019 | 0.002 | 0.002 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0519 | 0.6625 | 1 |
Schistosoma mansoni | phosphoglucomutase | 0.0092 | 0.0986 | 0.0986 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0273 | 0.0935 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0239 | 0.2925 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0707 | 0.0707 |
Leishmania major | ribonuclease H1, putative | 0.0092 | 0.0986 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0002 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.2281 | 0.2281 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0002 | 0.0002 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.