Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.3137 | 0.3211 | 1 |
Onchocerca volvulus | 0.0497 | 0 | 0.5 | |
Loa Loa (eye worm) | TKL/MLK/LZK protein kinase | 0.3137 | 0.3211 | 0.3211 |
Toxoplasma gondii | oxidoreductase, 2OG-Fe(II) oxygenase family protein | 0.0497 | 0 | 0.5 |
Trypanosoma cruzi | 2OG-Fe(II) oxygenase superfamily, putative | 0.0497 | 0 | 0.5 |
Toxoplasma gondii | tetratricopeptide repeat-containing protein | 0.0497 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.3187 | 0.3273 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3137 | 0.3211 | 0.3211 |
Loa Loa (eye worm) | hypothetical protein | 0.3137 | 0.3211 | 0.3211 |
Brugia malayi | Protein kinase domain containing protein | 0.3137 | 0.3211 | 1 |
Trypanosoma brucei | 2OG-Fe(II) oxygenase superfamily, putative | 0.0497 | 0 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.3137 | 0.3211 | 1 |
Toxoplasma gondii | hypoxia- inducible factor prolyl hydroxylase (phd2), putative | 0.0497 | 0 | 0.5 |
Trypanosoma cruzi | 2OG-Fe(II) oxygenase superfamily, putative | 0.0497 | 0 | 0.5 |
Toxoplasma gondii | oxidoreductase, 2OG-Fe(II) oxygenase family protein | 0.0497 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0497 | 0 | 0.5 |
Leishmania major | hypothetical protein, unknown function | 0.0497 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | uM | Inhibitory activity against purine nucleoside phosphorylase (PNPase); E means not determined | ChEMBL. | 3123692 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.