Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thymidylate synthetase | Starlite/ChEMBL | References |
Mus musculus | thymidylate synthase | Starlite/ChEMBL | References |
Lactobacillus casei | Thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Matrixin family protein | 0.1448 | 0.2472 | 0.3385 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.152 | 0.2623 | 0.8291 |
Brugia malayi | Hemopexin family protein | 0.1724 | 0.3055 | 0.44 |
Onchocerca volvulus | 0.1448 | 0.2472 | 0.3203 | |
Onchocerca volvulus | Matrilysin homolog | 0.1448 | 0.2472 | 0.3203 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0662 | 0.081 | 0.1112 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0584 | 0.0644 | 0.5 |
Onchocerca volvulus | 0.0584 | 0.0644 | 0.0002 | |
Brugia malayi | ADAMTS-like protease | 0.0567 | 0.0608 | 0.0137 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0772 | 0.1041 | 0.2027 |
Loa Loa (eye worm) | hypothetical protein | 0.053 | 0.0529 | 0.0844 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.1448 | 0.2472 | 0.3944 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.1764 | 0.314 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.3244 | 0.6269 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.152 | 0.2623 | 0.4185 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0584 | 0.0644 | 0.5 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.1764 | 0.314 | 0.4548 |
Loa Loa (eye worm) | hypothetical protein | 0.1764 | 0.314 | 0.5009 |
Echinococcus granulosus | thymidylate synthase | 0.0584 | 0.0644 | 0.0121 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0584 | 0.0644 | 0.5 |
Brugia malayi | Matrixin family protein | 0.1448 | 0.2472 | 0.3385 |
Brugia malayi | Matrixin family protein | 0.1448 | 0.2472 | 0.3385 |
Brugia malayi | angiogenesis inhibito | 0.0567 | 0.0608 | 0.0137 |
Loa Loa (eye worm) | matrixin family protein | 0.3212 | 0.6203 | 0.9894 |
Schistosoma mansoni | hypothetical protein | 0.1724 | 0.3055 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0583 | 0.0643 | 0.1025 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0584 | 0.0644 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0584 | 0.0644 | 0.1028 |
Onchocerca volvulus | Matrilysin homolog | 0.3284 | 0.6354 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1448 | 0.2472 | 0.3944 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.1847 | 0.3316 | 0.4856 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.0599 | 0.0676 | 0.0256 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.5008 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0584 | 0.0644 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1448 | 0.2472 | 0.3944 |
Mycobacterium ulcerans | hydrolase | 0.1764 | 0.314 | 1 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0772 | 0.1041 | 0.0541 |
Brugia malayi | Matrixin family protein | 0.3244 | 0.6269 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0584 | 0.0644 | 0.0455 |
Loa Loa (eye worm) | angiogenesis inhibito | 0.0287 | 0.0017 | 0.0027 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.3212 | 0.6203 | 0.9736 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0772 | 0.1041 | 0.0541 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0599 | 0.0676 | 0.1078 |
Brugia malayi | Matrixin family protein | 0.1448 | 0.2472 | 0.3385 |
Loa Loa (eye worm) | hypothetical protein | 0.1847 | 0.3316 | 0.529 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.1764 | 0.314 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0584 | 0.0644 | 0.5 |
Onchocerca volvulus | 0.1724 | 0.3055 | 0.4224 | |
Brugia malayi | thymidylate synthase | 0.0584 | 0.0644 | 0.02 |
Echinococcus multilocularis | thymidylate synthase | 0.0584 | 0.0644 | 0.0121 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.96 uM | Inhibitory effect on L. casei thymidylate synthase | ChEMBL. | 3373483 |
Ki (binding) | = 6.8 uM | Inhibitory effect on human lymphoblast (Molt/4F) thymidylate synthase | ChEMBL. | 3373483 |
Ki (binding) | = 12.2 uM | Inhibitory effect on murine leukemia (L1210) thymidylate synthase | ChEMBL. | 3373483 |
Km (binding) | = 1.28 uM | Inhibitory effect on murine leukemia (L1210) thymidylate synthase | ChEMBL. | 3373483 |
Km (binding) | = 1.34 uM | Inhibitory effect on human lymphoblast (Molt/4F) thymidylate synthase | ChEMBL. | 3373483 |
Km (binding) | = 4 uM | Inhibitory effect against L. casei thymidylate synthase | ChEMBL. | 3373483 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.