Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0225184 | 0.0130427 | 0.0130427 |
Toxoplasma gondii | hexokinase | 0.637169 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.637169 | 1 | 1 |
Trypanosoma brucei | hexokinase, putative | 0.637169 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.637169 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0245486 | 0.0163026 | 0.0163026 |
Loa Loa (eye worm) | hypothetical protein | 0.199982 | 0.298 | 0.288723 |
Loa Loa (eye worm) | hexokinase | 0.391569 | 0.605634 | 0.600422 |
Entamoeba histolytica | hexokinase 1 | 0.637169 | 1 | 0.5 |
Onchocerca volvulus | 0.637169 | 1 | 1 | |
Leishmania major | hexokinase, putative | 0.637169 | 1 | 0.5 |
Schistosoma mansoni | hexokinase | 0.637169 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.199982 | 0.298 | 0.288723 |
Echinococcus multilocularis | hexokinase | 0.637169 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.637169 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.637169 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.437187 | 0.678884 | 0.674641 |
Trypanosoma brucei | hexokinase | 0.637169 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.637169 | 1 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.637169 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0225184 | 0.0130427 | 0.0130427 |
Brugia malayi | Hexokinase family protein | 0.391569 | 0.605634 | 0.605634 |
Leishmania major | hexokinase, putative | 0.637169 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.637169 | 1 | 1 |
Brugia malayi | hexokinase | 0.637169 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.191586 | 0.284518 | 0.275063 |
Brugia malayi | hexokinase type II | 0.199982 | 0.298 | 0.298 |
Treponema pallidum | hexokinase (hxk) | 0.637169 | 1 | 0.5 |
Onchocerca volvulus | 0.637169 | 1 | 1 | |
Trypanosoma brucei | hexokinase | 0.637169 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.637169 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.637169 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.637169 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.637169 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.637169 | 1 | 0.5 |
Plasmodium falciparum | hexokinase | 0.637169 | 1 | 0.5 |
Plasmodium vivax | hexokinase, putative | 0.637169 | 1 | 0.5 |
Onchocerca volvulus | 0.391569 | 0.605634 | 0.605634 | |
Entamoeba histolytica | hexokinase 2 | 0.637169 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.191586 | 0.284518 | 0.284518 |
Loa Loa (eye worm) | hexokinase type II | 0.637169 | 1 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0245486 | 0.0163026 | 0.00330297 |
Onchocerca volvulus | 0.637169 | 1 | 1 | |
Onchocerca volvulus | Hexokinase homolog | 0.391569 | 0.605634 | 0.605634 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 15 uM | In vitro growth inhibitory activity against Plasmodium falciparum upon incubation at 37 degrees C with compound dissolved in DMSO using [3H]-hypoxanthine (50 uL) | ChEMBL. | 16161998 |
IC50 (functional) | = 83 uM | Inhibitory constant against Trypanosoma brucei rhodesiense upon incubation with the compound at 37 degrees C under a 5% CO2 atmosphere for 72 hours | ChEMBL. | 16161998 |
IC50 (functional) | > 88 uM | In vitro growth inhibitory activity against Leishmania donovani amastigotes at 37 degrees C under a 5% CO2 atmosphere for 96 hours | ChEMBL. | 16161998 |
IC50 (functional) | > 263 uM | In vitro growth inhibitory activity against Trypanosoma cruzi in rat L-6 cells upon incubation at 37 degrees C in 5% CO2 atmosphere for 4 days | ChEMBL. | 16161998 |
Ki (binding) | = 114 uM | Inhibitory constant against Leishmania major deoxyuridine 5'-triphosphate nucleotidohydrolase | ChEMBL. | 16161998 |
Ki (binding) | = 119 uM | Inhibitory constant against human deoxyuridine 5'-triphosphate nucleotidohydrolase expressed in E. coli BL21 (DE3) cells | ChEMBL. | 16161998 |
Ki (binding) | = 648 uM | Inhibitory constant against Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase expressed in E. coli BL21 (DE3) cells | ChEMBL. | 16161998 |
SI (binding) | = 0.2 | Selectivity index for Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase defined as (Ki Human)/(Ki P. falciparum) | ChEMBL. | 16161998 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 16161998 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.