Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 98 uM | In vitro growth inhibitory activity against Leishmania donovani amastigotes at 37 degrees C under a 5% CO2 atmosphere for 96 hours | ChEMBL. | 16161998 |
IC50 (functional) | = 145 uM | Inhibitory constant against Trypanosoma brucei rhodesiense upon incubation with the compound at 37 degrees C under a 5% CO2 atmosphere for 72 hours | ChEMBL. | 16161998 |
IC50 (functional) | > 163 uM | In vitro growth inhibitory activity against Plasmodium falciparum upon incubation at 37 degrees C with compound dissolved in DMSO using [3H]-hypoxanthine (50 uL) | ChEMBL. | 16161998 |
IC50 (functional) | > 293 uM | In vitro growth inhibitory activity against Trypanosoma cruzi in rat L-6 cells upon incubation at 37 degrees C in 5% CO2 atmosphere for 4 days | ChEMBL. | 16161998 |
Ki (binding) | > 1 mM | Inhibitory constant against Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase expressed in E. coli BL21 (DE3) cells | ChEMBL. | 16161998 |
Ki (binding) | > 1 mM | Inhibitory constant against human deoxyuridine 5'-triphosphate nucleotidohydrolase expressed in E. coli BL21 (DE3) cells | ChEMBL. | 16161998 |
Ki (binding) | = 707 uM | Inhibitory constant against Leishmania major deoxyuridine 5'-triphosphate nucleotidohydrolase | ChEMBL. | 16161998 |
SI (binding) | Selectivity index for Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase defined as (Ki Human)/(Ki P. falciparum); na= not relevant | ChEMBL. | 16161998 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.