Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.2706 | 1 | 0.5 |
Echinococcus granulosus | kelch protein 10 | 0.0001 | 0 | 0.0001 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0 | 0.0001 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0 | 0.0001 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.2706 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0524 | 0.1935 | 1 |
Echinococcus multilocularis | kelch protein 12 | 0.0001 | 0 | 0.0001 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.2706 | 1 | 0.5 |
Onchocerca volvulus | 0.0001 | 0 | 0.5 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0524 | 0.1935 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2706 | 1 | 0.5 |
Echinococcus granulosus | kelch protein 3 | 0.0001 | 0 | 0.0001 |
Echinococcus multilocularis | kelch protein 18 | 0.0001 | 0 | 0.0001 |
Brugia malayi | hypothetical protein | 0.0524 | 0.1935 | 0.1935 |
Echinococcus granulosus | kelch protein 18 | 0.0001 | 0 | 0.0001 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.2706 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0524 | 0.1935 | 1 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0197 | 0.0728 | 0.3763 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.1154 | 0.4265 | 0.4265 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0 | 0.0001 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.2706 | 1 | 0.5 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0197 | 0.0728 | 0.3763 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0 | 0.0001 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0524 | 0.1935 | 1 |
Onchocerca volvulus | 0.0001 | 0 | 0.5 | |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.2706 | 1 | 1 |
Echinococcus granulosus | kelch protein 12 | 0.0001 | 0 | 0.0001 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0 | 0.0001 |
Echinococcus granulosus | ectoderm neural cortex protein 1 | 0.0001 | 0 | 0.0001 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.2706 | 1 | 0.5 |
Onchocerca volvulus | 0.0001 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0198 | 0.073 | 0.3774 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0197 | 0.0728 | 0.3763 |
Echinococcus multilocularis | kelch protein 3 | 0.0001 | 0 | 0.0001 |
Echinococcus granulosus | kelch ECH associated protein 1 | 0.0197 | 0.0728 | 0.3763 |
Echinococcus multilocularis | ectoderm neural cortex protein 1 | 0.0001 | 0 | 0.0001 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.2706 | 1 | 0.5 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.1154 | 0.4265 | 0.4265 |
Echinococcus multilocularis | Kelch repeat type 1 | 0.0198 | 0.073 | 0.3774 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.2706 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0 | 0.0001 |
Onchocerca volvulus | 0.0001 | 0 | 0.5 | |
Echinococcus multilocularis | kelch protein 10 | 0.0001 | 0 | 0.0001 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0 | 0.0001 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0197 | 0.0728 | 0.3763 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 26 ug ml-1 | Cytostatic activity against HeLa cells | ChEMBL. | 7392032 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.