Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.1241 | 0.5541 | 0.8743 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.1031 | 0.4181 | 0.6464 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.1307 | 0.5967 | 0.9457 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.1357 | 0.6291 | 1 |
Entamoeba histolytica | hypothetical protein | 0.1144 | 0.4915 | 0.7694 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0818 | 0.2805 | 0.5 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.1031 | 0.4181 | 0.6464 |
Brugia malayi | hypothetical protein | 0.0917 | 0.3446 | 0.5231 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.1718 | 0.8624 | 1 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.1931 | 1 | 1 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0574 | 0.1231 | 0.1519 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.1357 | 0.6291 | 1 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.1357 | 0.6291 | 1 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.1931 | 1 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.1357 | 0.6291 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.076 | 0.2434 | 0.2822 |
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.1241 | 0.5541 | 0.5 |
Onchocerca volvulus | 0.1241 | 0.5541 | 0.5 | |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.1357 | 0.6291 | 1 |
Trypanosoma brucei | Prostaglandin E synthase | 0.1241 | 0.5541 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0917 | 0.3446 | 0.3995 |
Toxoplasma gondii | prostaglandin-E synthase | 0.1241 | 0.5541 | 0.5 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.1357 | 0.6291 | 1 |
Brugia malayi | sulfakinin receptor protein | 0.0917 | 0.3446 | 0.5231 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.1241 | 0.5541 | 0.8808 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0547 | 0.1058 | 0.123 |
Loa Loa (eye worm) | hypothetical protein | 0.1241 | 0.5541 | 0.6425 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0434 | 0.0324 | 0.0515 |
Loa Loa (eye worm) | hypothetical protein | 0.0597 | 0.1379 | 0.1599 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.1144 | 0.4915 | 0.7694 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.1241 | 0.5541 | 0.8808 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.1357 | 0.6291 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.076 | 0.2434 | 0.3536 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.