Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | 5' AMP activated protein kinase catalytic | 0.0233 | 0.4842 | 0.6192 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0233 | 0.4842 | 0.6192 |
Echinococcus multilocularis | 5' AMP activated protein kinase subunit gamma | 0.0313 | 0.7053 | 0.9019 |
Echinococcus multilocularis | AMPK beta subunit | 0.0111 | 0.1437 | 0.1838 |
Schistosoma mansoni | protein kinase subunit beta | 0.0111 | 0.1437 | 0.1838 |
Trypanosoma brucei | 5'-AMP-activated protein kinase subunit beta | 0.0111 | 0.1437 | 0.5 |
Schistosoma mansoni | protein kinase subunit gamma | 0.034 | 0.782 | 1 |
Giardia lamblia | 5-AMP-activated protein kinase, gamma-1 subunit | 0.034 | 0.782 | 1 |
Brugia malayi | loechrig isoform VII | 0.034 | 0.782 | 0.7454 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.9691 | 0.964 |
Trypanosoma cruzi | 5'-AMP-activated protein kinase subunit beta, putative | 0.0111 | 0.1437 | 0.5 |
Loa Loa (eye worm) | CAMK/CAMKL/AMPK protein kinase | 0.0233 | 0.4842 | 0.3976 |
Loa Loa (eye worm) | hypothetical protein | 0.0418 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0111 | 0.1437 | 0.5 |
Onchocerca volvulus | Alicorn homolog | 0.0097 | 0.1045 | 0.5 |
Loa Loa (eye worm) | loechrig isoform VII | 0.034 | 0.782 | 0.7454 |
Echinococcus multilocularis | 5' AMP activated protein kinase subunit gamma | 0.034 | 0.782 | 1 |
Echinococcus granulosus | AMPK beta subunit | 0.0111 | 0.1437 | 0.1838 |
Echinococcus granulosus | 5' AMP activated protein kinase subunit gamma | 0.034 | 0.782 | 1 |
Trypanosoma cruzi | SNF1-related protein kinase regulatory subunit beta, putative | 0.0111 | 0.1437 | 0.5 |
Echinococcus multilocularis | 5' AMP activated protein kinase catalytic | 0.0233 | 0.4842 | 0.6192 |
Brugia malayi | EST embl|AI107989|AI107989 comes from the 3' UTR, putative | 0.0233 | 0.4842 | 0.3976 |
Toxoplasma gondii | 5'-AMP-activated protein kinase subunit beta-1 family protein, putative | 0.0066 | 0.0166 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Survival (functional) | = 31.8 % | Cytoprotective activity against TNF-alpha, smac mimetic, z-VAD-induced necrosis in human HT-29 cells assessed as cell survival by measuring cellular ATP level at 4 uM after 24 hrs by Cell Titer-Glo assay relative to control | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.